DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jumu and Foxg1

DIOPT Version :9

Sequence 1:	NP_524302.1	Gene:	jumu / 41265	FlyBaseID:	FBgn0015396	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_001153584.1	Gene:	Foxg1 / 15228	MGIID:	1347464	Length:	481	Species:	Mus musculus

Alignment Length:	191	Identity:	54/191 - (28%)
Similarity:	87/191 - (45%)	Gaps:	40/191 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 GSPSSLSSSSASSPLGNVSNLVNIANNNTSGAGSGLVKPLQQKVKLPPVG-------------SP 408
            |.|:.|      :|:|        .:....|||:|    .::|......|             ..
Mouse   124 GGPAEL------APVG--------PDEKEKGAGAG----GEEKKGAGEGGKDGEGGKEGDKKNGK 170

  Fly   409 FPKPAYSYSCLIALALKNSRAGSLPVSEIYSFLCQHFPYFENAPSGWKNSVRHNLSLNKCFEKIE 473
            :.||.:||:.||.:|::.|....|.::.||.|:.::|||:.....||:||:||||||||||.|:
Mouse   171 YEKPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCFVKV- 234

  Fly   474 RPATNGNQRKGCRWAMNPDR----INKMDEEVQKWSRKDPAAI---RGAMVYPQHLESLER 527
             |....:..||..|.::|..    |.....::::.|....|.:   |||.:....|..::|
Mouse   235 -PRHYDDPGKGNYWMLDPSSDDVFIGGTTGKLRRRSTTSRAKLAFKRGARLTSTGLTFMDR 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jumu	NP_524302.1	Forkhead	411..499	CDD:278670	36/91 (40%)
Foxg1	NP_001153584.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..173		11/66 (17%)
		FH	173..261	CDD:214627	36/89 (40%)
		Required for interaction with TLE6. /evidence=ECO:0000269\|PubMed:16314515	241..336		12/54 (22%)
		Interaction with KDM5B. /evidence=ECO:0000250	375..398
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..447
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820