Protein Alignment CG12592 and Iws1

DIOPT Version :10

• Sequence 1: NP_731474.1
• Gene: CG12592 / 41263
• FlyBaseID: FBgn0037811
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_775617.1
• Gene: Iws1 / 73473
• MGIID: 1920723
• Length: 766
• Species: Mus musculus
• Alignment Length: 706
• Identity: 153/706 - (21%)
• Similarity: 254/706 - (35%)
• Gaps: 220/706 - (31%)

  Fly     8 KIGDAAYIQDELSSSLSSSVASKFKEFSKRKRISDSFSDLSEELERIGLRQMRKRIKLEKSFERT 72
            ::...|....|...:|...|:....|...|.:.|||.::          ...:.||...:| |..
Mouse   137 EVSKHAASDSEAEDTLQPQVSESDSEDPPRPQASDSENE----------EPPKPRISDSES-EEL 190

  Fly    73 PKKKVQTKKHLPPVRKKDSVKRRRIIIASPSDEEHDGKVQTNDDSSENKTEKPKNQSNCSSNASK 137
            ||.:|...:...|.|.:          ||.|:.|...|.:.:|..||   :.|:.|::.|.
Mouse   191 PKPRVSDSESEDPPRPQ----------ASDSESEELPKPRVSDSESE---DPPRPQASDSE---- 238

  Fly   138 LSEAAQLLNVSEEKS--------SISETELERSRQVALNELNKSERFNKTETQLDISVME----- 189
             ||......||:.:|        |.||.| :.||.....:.:.|:..||.|   |..|..
Mouse   239 -SEELPKPRVSDSESEDPQKGPASDSEAE-DASRHKEKPDSDDSDGENKRE---DSEVQNESDGH 298

  Fly   190 -----VDSSDHDEEE-KTEKVGAKNNRSLYEIVDSDDEEEQDQDQSDAAKP-----AESEN---H 240
                 :.|||.:||| |.:|            :||||:||::.|:...||.     ::||:   :
Mouse   299 TDRKGLHSSDSEEEEPKRQK------------IDSDDDEEKEGDEEKVAKRKAAVLSDSEDDAGN 351

  Fly   241 SEIKKS-------TSFMDQMSGAKGNKSVYEIMDSYETEDPKEAGKNEES-----DKD---KPAE 290
            :..|||       .|..|.:|...|.:......||.|     ||||.|.|     |||   ..:|
Mouse   352 ASAKKSRVVCDADDSDSDVVSDKSGKRETTVASDSEE-----EAGKEESSVKKKEDKDLFGSDSE 411

  Fly   291 NG-------------KSDKDKQAETEMSDEDKPSEIKSPSTIKKSIISTADEEALLAELASSDLS 342
            :|             ..|::::..|..:.||...| |:.:.:|::..|.:|:.....: ....||
Mouse   412 SGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEE-KNETQLKEAEDSDSDDNIKRGK-HMDFLS 474

  Fly   343 HLEKMFNPLQKSRRQSLHVPSPELAAKNPKLRRRSERVEVGNDFCPSQSFVDM--VAEKKRQKNK 405
            ..|.|   ||:.:         .:..|..:.|.....:...:|.. |...|.|  .||:.||.|.
Mouse   475 DFEMM---LQRKK---------SMCGKRRRNRDGGTFISDADDVV-SAMIVKMNEAAEEDRQLNN 526

  Fly   406 RKRLS-KSLSGAP--------EDLEE-------------------------MEIKHE-RKRLKSS 435
            :|:.: |.|:..|        :||:|                         ::|:.| .|.|:..
Mouse   527 QKKPALKKLTLLPTVVMHLKKQDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQEL 591

  Fly   436 HGASTDSMEEDNENETMTVAEEHHSDGEVSNGEV----------PI------------EEKPTTS 478
            ...|.::::.......:....:|..:.. ||.::          ||            ||:....
Mouse   592 PSVSQETLKHSGIGRAVMYLYKHPKESR-SNKDMAGKLINEWSRPIFGLTSNYKGMTREEREQRD 655

  Fly   479 SEK-PSASELPEEGNSAPPALKKDVKRLQAARQAVSHAVNLLAPPKATEAEPRTLSRKLSPQPP- 541
            .|: |....|...|...|   ::|::::....:      ..|.|     .:|...:|...|.|.
Mouse   656 LEQMPQRRRLSSTGGQTP---RRDLEKVLTGEE------KALRP-----GDPGFCARARVPMPSN 706

  Fly   542 ---------VVDKKSAKQKKKGKK---------------KQKPQEASPLKSSDEEN 573
                     .|:.:|::.:...||               ::|.:.|..:|.|.|.|
Mouse   707 KDYVVRPKWNVEMESSRFQASSKKGISRLDKQMRKFTDIRKKSRSAHAVKISIEGN 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12592	NP_731474.1	None
Iws1	NP_775617.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..466		95/379 (25%)
		MSCRAMM_ClfA	<66..428	CDD:468110	86/340 (25%)
		Integrase domain-binding motif (IBM). /evidence=ECO:0000250|UniProtKB:Q96ST2	416..442		2/25 (8%)
		Interaction with SUPT6H and ALYREF. /evidence=ECO:0000250	470..766		58/321 (18%)
		TFIIS_I	<475..739	CDD:469629	50/291 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	643..679		8/38 (21%)