DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12592 and Tchhl1

DIOPT Version :9

Sequence 1:	NP_731474.1	Gene:	CG12592 / 41263	FlyBaseID:	FBgn0037811	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_082038.2	Gene:	Tchhl1 / 71325	MGIID:	1918575	Length:	638	Species:	Mus musculus

Alignment Length:	579	Identity:	113/579 - (19%)
Similarity:	213/579 - (36%)	Gaps:	138/579 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 SKLSEAAQLLNVSEEKSSISETELERSRQVALNELNKSERFNKTETQLDISVMEVDSSDHDEEEK 200
            |.|:...:|::.||:..::....:..:.|..:......||.        |...|:.||.....|:
Mouse    90 SLLNSEPRLMSKSEKIDAVDLGAIGGNIQQVVGVGPTQERL--------IFPSEMASSGQPSNEE 146

  Fly   201 TEKVGAK---------NNRSLYEIVDSDDEEEQDQDQSDAAK-----PAESENHSEIKKSTSFMD 251
            .| ||.:         ...||...|...::.|..|.:.||.:     ||...:..:.|::|
Mouse   147 GE-VGDEPMVSPCEDIKTHSLPRNVSEPNDPENQQPKEDAQEVAQNVPATEYDGVQFKRNT---- 206

  Fly   252 QMSGAKGNKSVYEIMDSYETEDPKEAGKNEES---DKDKPAENGKSDK--DKQAETEMSDEDKPS 311
                      |.|:        ||::....:.   ::.||:......|  |...:....||:..|
Mouse   207 ----------VVEV--------PKQSTSPTQEIPRERSKPSRRLSDTKISDHMIQRPTEDEEHTS 253

  Fly   312 EIKSPSTIKKSIISTADEEALLAELASSDLSHLEKMFNPL--------QKSRRQSLHVPSPELAA 368
            ..:.|...|:...:.::...|....|:...|..:::|.|:        |::.:.:..:| ||...
Mouse   254 TTQDPFLQKRDKATGSENTDLSVVAATRKSSQTQEIFEPMDDTKLSEAQETGKDAGRIP-PETNL 317

  Fly   369 KNPKLRRRSERVEVGNDFCPSQSFVDMVAEKKRQKNKRKRLSKSLSGAPEDLEEMEIKHERKRLK 433
            :.||...:                   |||.              .|.|....|...:.:..:.:
Mouse   318 EEPKADAK-------------------VAES--------------HGLPAQEREHNTRDQSVQSR 349

  Fly   434 SSHGASTDSMEED----NENETMTVAEEHHSDGEVSNGEVPIEEKP----TTSSEKPSASELP-- 488
            |.:.:.|.|..|.    .|:|.:|::..  :|.|..:.:  .:|.|    ...::|.||::.|
Mouse   350 SRNVSETSSRGEQEGEWKEHERITLSPT--ADAETQDEK--CQEFPGSWRENDAKKDSAAKDPSS 410

  Fly   489 EEGNSAPPALKKDVKRLQAARQA-----VSHAVNLLAPPKATEAEPRTLSRKLSPQPPVVDKKSA 548
            ||||...|.:|:|....:.||.:     .:..:|..:|......|.|..|::|:|    ::|:|.
Mouse   411 EEGNQNLPEIKEDSVSGKEARHSEEDTVYAFEINKNSPAAEETLETRERSQELAP----LEKQSQ 471

  Fly   549 KQKKKGKKKQKPQEASPLKSSD----EENHGHRIRTNAGYVTVVDEPPTKVPIIELIKTSSGMVR 609
            ::|.:..:.|.    .|::..|    |::.....:::.|:..:   |.:..|  |:.|:||.:
Mouse   472 RKKHRATRIQD----KPVRKEDHNEGEDSELSLTQSDEGFCEI---PNSLAP--EVGKSSSEI-- 525

  Fly   610 VEPCTPKQKYFR-ELPPTPKMHGFREEPGPSGMSRKRAKHAAPKVEHNSAKQAALRFKE 667
            .||..|:....: :.....|.......|.|.       |..||.......:...|..:|
Mouse   526 AEPHVPEDSQSQIDHHGDAKQESHTNNPDPQ-------KQGAPGESSREQEAVVLSIQE 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12592	NP_731474.1	None
Tchhl1	NP_082038.2	S-100	2..86	CDD:238131
		EF-hand_7	13..75	CDD:290234
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..638		104/527 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843294
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930