DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12592 and CG17111

DIOPT Version :9

Sequence 1:	NP_731474.1	Gene:	CG12592 / 41263	FlyBaseID:	FBgn0037811	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_651119.2	Gene:	CG17111 / 42727	FlyBaseID:	FBgn0039048	Length:	792	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	106/553 - (19%)
Similarity:	187/553 - (33%)	Gaps:	135/553 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 ASPSDEEHDGKVQTNDDSSENKT-EKPKNQSNCS----SNASKLSEAAQLLNVSEEKS------- 152
            |:|.|||:          .||:. |:.....|||    :|:|.:...|:.|.:|:::.
  Fly   243 AAPYDEEY----------MENQCHERAIESDNCSYELYANSSFIYAEARYLGLSQKECQAMCSHE 297

  Fly   153 ----------------SISETELERSRQVALN----ELNKSERFNKTETQLDISVMEVDSSDHDE 197
                            |:||..|.....|:|.    :|.::..:.:....||:.|.      ...
  Fly   298 AKFYCQGVSFYYVNQLSLSECLLHSEDIVSLGPRSLKLRENSVYMRRVKCLDVRVF------CTR 356

  Fly   198 EEKTEKVGAKN--NRSLYEIVDSDDEEEQDQDQSDAAKPAESENHSEIKKSTSFMDQMSGAKGNK 260
            :|.|.|...|:  ...:|..:.|.|...:...........:.  .||:|::..         |..
  Fly   357 DEMTIKYNPKDWFVGKIYASMHSKDCLARGSGNGSVLLTLQI--GSEVKENRC---------GIL 410

  Fly   261 SVYEIMDSYE----------TEDPKEAGKNEESDKDKPAENGKSDKDKQAETEMSDEDKPSEIKS 315
            ..||:...|:          ..:|     |.::..|:..:.|....:  |.|.:....:.|.:.|
  Fly   411 RAYEMTQEYQRTFISALVVIQNNP-----NVQTQGDRLIKVGCIQSN--ATTSLGVSVRDSSVDS 468

  Fly   316 PSTIKKSIISTADEEALLAELASSDLSHLEKMF---NPLQKSRRQSLHVPSPELAAKNPKLRRRS 377
            ...:..:|       ||     .|.|.:.|.||   ..:..:.....| |.|.::.:...|..:.
  Fly   469 SEPVPSAI-------AL-----ESSLEYTEHMFPHEGVVHYNSSTGPH-PHPSISLQILDLSHQH 520

  Fly   378 ER--VEVGNDFCPSQSFVDMVAEKKRQKNKRKRLSKSLSGAPEDL-EEMEIKHERKRLKSSHGAS 439
            |.  |::|.:.     .:.:|||.                :|:.| |.||:  :...|......|
  Fly   521 ETNDVQIGQNL-----ELQIVAEY----------------SPQQLAEHMEL--QLAPLPDFRATS 562

  Fly   440 TDSMEEDNENETMTVAEEH-HSDGEVSNGEVPIEEKPTTSSEKPSASELPEEGNSAPPALKKDVK 503
            ..:...||||..:.:.|.. .:|..|    .|..|:..|:|.....:.......|....:..|||
  Fly   563 LVAKTADNENFVLLIDERGCPTDASV----FPALERVHTASRSMLRARFHAFKFSGTANVSFDVK 623

  Fly   504 -RLQAARQAVSHAVNLLAPPKATEA-EPRTLSRKLSPQPPVVDKKSAKQKKKGKKKQKPQEASPL 566
             |....|.:.|:.::.....:..:| :|......|..|.||..........:.....:.||..||
  Fly   624 IRFCVERCSPSNCISSSWQRRRRQADQPDRRPEDLRVQNPVYISTVVDVAPQPDNFTRSQEELPL 688

  Fly   567 K------SSDEENHGHRIRTNAGYVTV--VDEP 591
            .      ..|:.|....:....|.:.:  :|:|
  Fly   689 NYNIRVHGPDQSNTNSYLYGERGVLLIAGIDDP 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12592	NP_731474.1	None
CG17111	NP_651119.2	PAN_1	159..255	CDD:278453	7/21 (33%)
CG17111	NP_651119.2	PAN_AP_HGF	270..344	CDD:238532	12/73 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JEZ
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900