Protein Alignment sle and LOC4577154

DIOPT Version :10

• Sequence 1: NP_731472.1
• Gene: sle / 41262
• FlyBaseID: FBgn0037810
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: XP_001237516.4
• Gene: LOC4577154 / 4577154
• VectorBaseID: AGAMI1_004672
• Length: 1803
• Species: Anopheles gambiae
• Alignment Length: 1604
• Identity: 366/1604 - (22%)
• Similarity: 589/1604 - (36%)
• Gaps: 492/1604 - (30%)

  Fly    60 DVRTPTRTRRASLARGETPEPTTPS--SVKRTARTPAKNTRSVRQQLTLTEEPEENEVKQEKPSP 122
            |...|||..|.:|.|....:..||.  :...|..||.|:..:.::...|      |.:::.:..|
Mosquito     4 DEEVPTRVTRGALRRRSVDQEATPQKPAGAATGGTPKKSASTTKKVNAL------NAIQETEGRP 62

  Fly   123 SPSPVPKEGKGKAQRKPSVSPSPGRTLTPNQ----------QSDEKRVTRSMSQTPP-------- 169
            |   .|..|:...:|....|.:|  |:.||:          .::..|.:|:.|.|..
Mosquito    63 S---TPTVGRNTRRRMSETSDTP--TILPNKLVQNLKEAEIGAEPGRRSRNTSLTEENLNELNAA 122

  Fly   170 -------MPTRSSSNTPRDLNDS-----------PKVEQKAKPNIKTTPKVAVRLEKLSMDKF-S 215
                   :|||  |.||..|..|           |.|.:..:.|..|:...:|:...::..|. |
Mosquito   123 YEGGSSVLPTR--SRTPARLRASNEALASMNSPQPAVRRSTRRNSVTSDDGSVQSLPVTTPKLTS 185

  Fly   216 GKKMEKAKPLIVPDELKD--NGVVEEQNKSITEAHSQAPETHESAQPDK-----------DAGKQ 267
            |.::.|...:|..|...|  ..|..|.:...|...|.|.:...|..|.:           ||...
Mosquito   186 GLRVLKDDTIIEEDASDDRAESVSSEASTRTTRRQSTAAKKSASPSPRRTAESPVSSVKTDATPP 250

  Fly   268 SFLK----SFTTLSKIQGSSKALH--------PDESADTITKITPTSTSKKIEENMDDVFET-LR 319
            ..:|    |.:.|...:||.:..:        .|:|..:..| ||||.||::...::|:..: |:
Mosquito   251 RAMKTPRVSLSPLMLPKGSPRYKNVSFCDDSKQDDSHSSFPK-TPTSVSKEVVIVVNDLRNSDLK 314

  Fly   320 VESPKVERKIETLQKVHTVG-------------------TPEIKEKDEPVGVDNEIKTKTETPQK 365
            ..||||:|::....|....|                   .||:|..||...:....|...:|
Mosquito   315 GVSPKVDREVNLPGKSEPTGDQLKSSAKSPKSESFVGDSVPEMKANDESSSIAASPKPGKDT--- 376

  Fly   366 IEPPIIESKVETQQ----LIDHPQIEKKRDTPQNVSTVDLMDTSPEKDESMEDQEFLDAEDSIVQ 426
            ||.|...||.:...    |||:.  .:..|:..|||.::|:::|           .::..|||:
Mosquito   377 IEQPNSTSKDKMNSSSTVLIDNG--TEAIDSSNNVSGIELLESS-----------VVEISDSIM- 427

  Fly   427 LEPQTDEPVEKPKELEFVDLDDDEPVFPSEAPKYVEDSKEVHPDDSMDDDKQNKIDVTEVIHLPS 491
                                         ||...|:|:..|....:.:.:|           |..
Mosquito   428 -----------------------------EANTSVKDTSSVANKSTSEGEK-----------LSQ 452

  Fly   492 IRARAVRSPAVEQKKSVDFNNDTDDLEVEKKRFPKTPGREKVPVCRILTPKPETPLKLALQKGRN 556
            ..:::||..|.:         ..|:..|.|:
Mosquito   453 SWSQSVRRSATK---------GIDEFSVRKQ---------------------------------- 474

  Fly   557 SSTPILKDQERGLSNSTEELHPAPPQIDAIKPFDELESKNAKDEMVEQSPMSKQKAENKILARLE 621
                  ::||| |...||:|..||                .|..:..:||.:|..:.:      |
Mosquito   475 ------EEQER-LEEETEKLQKAP----------------LKSPLKPRSPAAKAASAD------E 510

  Fly   622 SFEEDVEDHGNEEENEEEHE-EDKSISEFVDLEAEDAGKDYMSGDSMDSSLRREMEENEIPIDGE 685
            |.:||     |::|.|:|.| :||  :|.:|.||.:. :.|.||||:.|.||||||||||...||
Mosquito   511 SIDED-----NDDELEDEEEAQDK--NELLDDEAVEM-EGYESGDSLASDLRREMEENEIMDQGE 567

  Fly   686 SVGSKDTEES---TPEESDGDDSFIVSDNEDEEDLGQLCYSSGEDE-IEDAEESE-QAERSSVK- 744
            .:||:||||:   ..:|.||:||:|||..::.|.|       .||| ::|.|:.: |.:.||||
Mosquito   568 DLGSEDTEENDEQEEDEEDGNDSWIVSSGDEAEQL-------NEDELLKDTEDEDLQTKNSSVKD 625

  Fly   745 -------RRRIIIASPSDEEHDGKVQSNDDSSENKTEKPKNQSNCSSNASKLSEAAQLLNVSEEK 802
                   :||.||....|.:.|.|.     |.|.:.|..|:..|.||..|......:..|...:|
Mosquito   626 KEKTKTPKRRRIIEMVDDSDEDTKA-----SDEERKETAKSPRNLSSKRSLTPVGGKENNTPTKK 685

  Fly   803 SSISETELERSRQVALNELNKSERFNKTETQLDISVMEVDSSDHDEEEKTEKVGAKNNRSLYEIV 867
            .::|:          :|:..|::                     |:::......|||:.|:....
Mosquito   686 LNLSQ----------INDAVKNK---------------------DQDKPANNTPAKNDTSMESST 719

  Fly   868 DSDD--GEEQDQDQSDADKPAESENHSEIKKSTSFMDQMSGAKGNKSVYEIMDSYETEDPKEAGK 930
            |...  ..|.....:.|.|....:..:.:..:|..:.......|.|.|     :.|.::...:|.
Mosquito   720 DEQQVGNNETMLPATPAHKTPSKDTGAALHSATKSLSNSKHGNGEKEV-----AAEDDENDTSGN 779

  Fly   931 NEESDKDKPAENG-----KSDKDKQAETEMSDEDKPSEIKSPSTIKKSIISTADEEALLAELASS 990
            :|...:|  ||:|     |||...:.:..:|.....|.|.|..:...:.|:|.|      .:...
Mosquito   780 SETMFQD--AEDGGETVQKSDDAMEKDVSLSKSPTKSVIASRKSFPAASITTKD------VIGRK 836

  Fly   991 DLSHLEKMFNPLQKSRRQSLHVPSPELAAKNPKLRRRS---ERVEVGN--------DFCPSQSFV 1044
            .|.....|...:|....:......|: |.:|.::....   |.|||.|        :..|::..:
Mosquito   837 SLPANANMQAAIQSETDEGGESSQPD-ATQNDEVEEVEALVENVEVENAEHDKTQAEPAPAEFTL 900

  Fly  1045 DMVAEKKRQKNKRKRLSKSLSGAPEDLEEMEIKHERKRLKSSHGASTDSMEEDNENETMTVAEEH 1109
            |..|::...|..|    ||:...|....:..|...:||...:.|       ||...:|.|.....
Mosquito   901 DQPADEAPTKPGR----KSMPAVPLISAQFYIGASKKRATIAGG-------EDAHVQTSTPKSNQ 954

  Fly  1110 HSDGEVSNGEVPIEEKPTTSS--------------------------EKPSASE-----LPEE-- 1141
            ...|:....:.|:|:|.||::                          :||...:     ||.:
Mosquito   955 SLSGKDKGKKTPVEKKATTANGGSTVLNPFAQAKNKARLSLDSGAGQQKPEKKDKLRRSLPSQFV 1019

  Fly  1142 EETVAVEELLM-----EKPKTCDSPRSEERPTEIV------TSKPKGMAPVKVEKTAE-YYLAYC 1194
            ||::.|:|..|     |:|...|..:......|:|      ..|.:..||....|..| |.||
Mosquito  1020 EESMEVDEAPMNENVAEEPSKPDDDKEMNDEVEVVENQEPENGKQQSKAPKPKRKALEDYDLA-- 1082

  Fly  1195 HNLLEAANEA--KLKEKKEHLASGAKQKK--PKRI--------------AAQAPSKLLG------ 1235
             |:|...||.  :.||:|:.:||..::||  .||:              ||.|.:...|
Mosquito  1083 -NILSRCNEVIREDKERKKEVASAIRKKKEEKKRLRELEKQEELEAAKAAAAAAAAAAGSGGTTN 1146

  Fly  1236 ---------TIGSESETNTAKSSKQPPALKKDVK----------RLQAARQAVSHAVNLLAPPKA 1281
                     |.|::|.:...:..|:....|..||          |.:...||:.|.:.::...|.
Mosquito  1147 GDDGGLNSSTTGNDSLSQGGEGLKKKKKRKPKVKNYLLDELAETRKERLEQALRHKLEVIERRKQ 1211

  Fly  1282 TEAEPRTLSRKLSPQPPVVDKKS-----------AKQKKGKKKQKPQEASPLKSSDE-------- 1327
            .:.|     |:|..|.. :||::           ||.:|.|||||.:  |..:|||:
Mosquito  1212 RKKE-----RQLEQQKQ-LDKENGNATGASGGIGAKLEKIKKKQKAK--SNQESSDKSKSPPVRV 1268

  Fly  1328 -----------ENHGHRIRTNAGYVTVVDEPPTKVPKIELIKTSSGMVRVEPCTPKQKYFRELPP 1381
                       :||..::::.|       :...|..|.||         :.|...|:::.:
Mosquito  1269 ALSAFAVFNQLQNHPEQVQSLA-------DKTQKSEKSEL---------MAPAVEKKQHKK---- 1313

  Fly  1382 TPKMHGFREEPGPSGMSRKRAKHAAPKVEHNSAKQA-ALRFKEQ 1424
            :||.   .|...|...:::.||.....|....|||| ||:..||
Mosquito  1314 SPKK---EEASDPQPEAKEAAKTDKVAVADEKAKQANALKDSEQ 1354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sle	NP_731472.1	MSCRAMM_ClfA	<656..989	CDD:468110	94/352 (27%)
LOC4577154	XP_001237516.4	None