Protein Alignment Bruce and BIR1

DIOPT Version :10

• Sequence 1: NP_001262460.1
• Gene: Bruce / 41260
• FlyBaseID: FBgn0266717
• Length: 4976
• Species: Drosophila melanogaster
• Sequence 2: NP_012622.3
• Gene: BIR1 / 853551
• SGDID: S000003849
• Length: 954
• Species: Saccharomyces cerevisiae
• Alignment Length: 1141
• Identity: 223/1141 - (19%)
• Similarity: 371/1141 - (32%)
• Gaps: 361/1141 - (31%)

  Fly   141 TELESEGLECPCDISNELTQKINQAQLKAKKGIKAQRWNTICLEVPYSSLKLVSNNMVILLKRLE 205
            ::|:.:.:.| | ..:..|..:...:.|.|..::.      ...:....|.:..|..|.||..|.
Yeast    63 SKLKKDSVRC-C-YCHRQTYNVRDCRSKRKDVLET------LSNIMRQHLTVTDNKQVCLLIYLR 119

  Fly   206 RHIPVLAIASAINERLTDMMMGSRVPDFGWN----FSN--FQRVLMHSEAVRRQTF-EKWPHMDY 263
                        |:.|||......|.|  |.    |||  .:.|:    .:|:.|| :.|||...
Yeast   120 ------------NKLLTDYSFHMGVSD--WKNDKYFSNPDDENVI----NLRKFTFQDNWPHSGS 166

  Fly   264 KWALP---DQMAQAGFYHQPSS-SG-----------EDRAMCFTCSVCLVCWEKTDEPWSEHERH 313
            :...|   ::|..||.....|| .|           .|...|..|...|..|...|:|.|.|.:.
Yeast   167 QNEHPLGIEKMVNAGLMRYDSSIEGLGDPSMDKTLMNDTCYCIYCKQLLQGWSINDDPMSRHYKV 231

  Fly   314 SP--LCPF---------VKGE---YTQNVPLSITYATNPALPAPGLGFDIISNSDYANVLC---- 360
            |.  .|.|         :|.:   .|:|..:|.|...|...       ::|:....:...|
Yeast   232 SQNGNCYFFQTRNRFERIKNDNDSITKNCEVSPTLGENGKR-------EVINTKTASQRQCPLFE 289

  Fly   361 TSCSQTGELSVWSIERHLKLMHTFHVPTLLNYIFEESFEWARVTAICVLPNARARTKVNYVYSAA 425
            :..|.||                   |.|.:|                    ..:|.:    |..
Yeast   290 SPPSSTG-------------------PQLDDY--------------------NEKTDI----SVI 311

  Fly   426 NYGGSGSSNGAGCNSGLNAVSGGKFGSVNAQHITSTSTLRAGVVGSKIVLGVSVRQSSGELALRM 490
            .:..|......|.|...|:|...:  .:|.::  .::||..|.:...::
Yeast   312 QHNISVLDGAQGENVKRNSVEEKE--QINMEN--GSTTLEEGNINRDVL---------------- 356

  Fly   491 VVLNIVEVDRNSESSTSVSNDSGSVSSGGGQLMKSSSPMVNVSAENNATVTQVNLESKDDDNKAM 555
                   .|:....||..:.:   :.....||.:||||:                 .|....|.:
Yeast   357 -------ADKKEVISTPTAKE---IKRPNVQLTQSSSPI-----------------KKKRKFKRI 394

  Fly   556 TPYEKFADGFDSNGFVSALMTYNKNNGVSQNTDDASALYDFDLCTLSQILDHNLEEPLSLMVGSS 620
            :| .|..|..||...::       ||..:.:..|...:.||                      :|
Yeast   395 SP-RKIFDEEDSEHSLN-------NNSANGDNKDKDLVIDF----------------------TS 429

  Fly   621 NTVNVSNIGMGNEINKLVVDVEISHQNNNNNNNN---NNEASSLGGNSSNNNNNIM-----IN-- 675
            :.:...::|..|.|.....| |.|..|..:|..:   ...:..|.|..|:|:|.|.     ||
Yeast   430 HIIKNRDVGRKNAILDDSTD-EFSFSNQGHNTFDIPIPTSSHLLKGIDSDNDNVIREDDTGINTD 493

  Fly   676 -GGTNSSIDKMTAIEEIDCVVESWTSVKRMNALDGASSGVNGVNHMDQEVIEIAEILPTTPKCNQ 739
             .|.:|..:|.:...|.|.   :::.||    |.|..|..|              ||..|...:|
Yeast   494 TKGASSKHEKFSVNSEEDL---NFSEVK----LTGRDSSTN--------------ILIRTQIVDQ 537

  Fly   740 LLVKLLRTKAPEAEGSKIIMAT--VAKEEEEEDEEQRTDESMETD-----------NNAEGNVAA 791
            .|..:.|.|.|.. ||..:..|  :.::..|:.|.|..:...:.|           :|..|:.::
Yeast   538 NLGDIDRDKVPNG-GSPEVPKTHELIRDNSEKREAQNGEFRHQKDSTVRQSPDILHSNKSGDNSS 601

  Fly   792 QLLVFDYDDTEISNDYTLAMTFSRAKFPKQLCILPHFNSSPEHKDAGSICVVCADGTVE------ 850
            .:.....::....|..|       :..|..:...|..|.......:.|..||..:..::
Yeast   602 NITAIPKEEQRRGNSKT-------SSIPADIHPKPRKNLQEPRSLSISGKVVPTERKLDNINIDL 659

  Fly   851 IYSLADFQGTMVIEEEGEHFESVVYCR------NLDR-LCCCSRQGGLLFYSLSDGENDSG---- 904
            .:|.:||..:...|:..:. .||:...      ||.| |.......||      ..|.|.|
Yeast   660 NFSASDFSPSSQSEQSSKS-SSVISTPVASPKINLTRSLHAVKELSGL------KKETDDGKYFT 717

  Fly   905 --DELLEMDDDCST-TLTQAADVSVTDGGRQLARTDLLGKTLLANESICMDAGSEAAAIPNSSSA 966
              .|.:::.:|.|. ..|...::.:.:.|..:|..:...:.|...|.    :|.| ..||..||.
Yeast   718 NKQETIKILEDVSVKNETPNNEMLLFETGTPIASQENKSRKLFDEEF----SGKE-LDIPIDSST 777

  Fly   967 AQGAHVQTSPSASSAPSTNANLLAYKTA---DLTLEDLKVFYALTQFDDKLTVYSAEVPSCWNDI 1028
            .:...| ..|.....||...||::..::   :..||:.:          |.|..|
Yeast   778 VEIKKV-IKPEFEPVPSVARNLVSGTSSYPRNSRLEEQR----------KETSTS---------- 821

  Fly  1029 GQVQNQRKQSQNMRHGGDERDFTRTWRLHNDATTW---DE--HIIELNLAQPVSLGHI------- 1081
              :.:..|:..:...|.:|::        .:|..|   ||  |::: |....: |.:|
Yeast   822 --LADNSKKGSSFNEGNNEKE--------PNAAEWFKIDENRHLVK-NYFHDL-LKYINNNDATL 874

  Fly  1082 ------DLKFTVYQQCSNPA-AIQVTLLKQNNNGFGYRMKGPHSSYKPNVIDD---NIDLSYIAN 1136
                  ||.|.:.|.   || .:.:|.    ||....:::    |.|...|||   .:|
Yeast   875 ANDKDGDLAFLIKQM---PAEELDMTF----NNWVNLKVQ----SIKREFIDDCDKKLD------ 922

  Fly  1137 ENPVLSEEYLLAHN-AEVLAGPIELSSCIDLCDQGG 1171
               :|..:|..|.| .|.|....:|   ||:..:.|
Yeast   923 ---ILRRDYYTATNFIETLEDDNQL---IDIAKKMG 952

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bruce	NP_001262460.1	BIR	251..321	CDD:459891	25/96 (26%)
		BIRC6	3539..3664	CDD:463547
		UBCc_BIRC6	4631..4835	CDD:467430
BIR1	NP_012622.3	BIR	18..>76	CDD:469588	3/14 (21%)
		BIR	151..241	CDD:197595	25/89 (28%)