DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bruce and UBE2Z

DIOPT Version :9

Sequence 1:	NP_001262460.1	Gene:	Bruce / 41260	FlyBaseID:	FBgn0266717	Length:	4976	Species:	Drosophila melanogaster
Sequence 2:	NP_075567.2	Gene:	UBE2Z / 65264	HGNCID:	25847	Length:	354	Species:	Homo sapiens

Alignment Length:	199	Identity:	80/199 - (40%)
Similarity:	109/199 - (54%)	Gaps:	22/199 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  4626 GDRYHPSRVKRLAQEAVTLSTSLPLSFSSSVFVRCDTDRLDIMKV--LITGPADTPYANGCFEFD 4688
            |:|..|..:.|:.::.:::....|    ..:||..||  :|:.|:  |||||.||||..|.|.|.
Human    93 GERTAPQCLLRIKRDIMSIYKEPP----PGMFVVPDT--VDMTKIHALITGPFDTPYEGGFFLFV 151

  Fly  4689 VFFPPDYPNQPMLINLETTGRHSVRFNPNLYNDGKVCLSVLNTWHGRPEEKWN-AQTSSFLQVLV 4752
            ...|||||..|..:.|.|||.::||||||.|.:||||||:|.||.|   ..|: ||:.|  .||:
Human   152 FRCPPDYPIHPPRVKLMTTGNNTVRFNPNFYRNGKVCLSILGTWTG---PAWSPAQSIS--SVLI 211

  Fly  4753 SIQSLILVPEPYFNEPGFERSRGSPSGTNSSREYNSNIYQACVRWAMLEQIRSPSQC---FKDVI 4814
            ||||| :...||.||||||:.|    ....|:.||..|....:|.|:.:.:.....|   .:.|:
Human   212 SIQSL-MTENPYHNEPGFEQER----HPGDSKNYNECIRHETIRVAVCDMMEGKCPCPEPLRGVM 271

  Fly  4815 HKHF 4818
            .|.|
Human   272 EKSF 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bruce	NP_001262460.1	BIR	251..321	CDD:279047
		DUF3643	3539..3664	CDD:289152
		UQ_con	4636..4790	CDD:278603	70/156 (45%)
UBE2Z	NP_075567.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		UBCc	103..221	CDD:238117	58/129 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0895
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1404665at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820