DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Bruce and NAIP

DIOPT Version :9

Sequence 1:NP_001262460.1 Gene:Bruce / 41260 FlyBaseID:FBgn0266717 Length:4976 Species:Drosophila melanogaster
Sequence 2:NP_001333799.1 Gene:NAIP / 4671 HGNCID:7634 Length:1403 Species:Homo sapiens


Alignment Length:1700 Identity:305/1700 - (17%)
Similarity:543/1700 - (31%) Gaps:640/1700 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   138 NCITELES-EGLECPCDISNELTQKINQAQLKAKKGI------KAQRWNTICLEVPYSS------ 189
            |.:.||.: .||:. ..::.||.::..:.:.|.:||.      :|:|..|.....||||      
Human    18 NLLPELSALLGLDA-VQLAKELEEEEQKERAKMQKGYNSQMRSEAKRLKTFVTYEPYSSWIPQEM 81

  Fly   190 -------------LKLVSNNMVILLKRLERHIPVLAIASAINERLTDMMMGSRVPDFGW------ 235
                         ::....::::....|.| :|:     ..::|..        ||.|:      
Human    82 AAAGFYFTGVKSGIQCFCCSLILFGAGLTR-LPI-----EDHKRFH--------PDCGFLLNKDV 132

  Fly   236 -NFSNFQ-------------RVLMHSEAVRRQTFEKWPHMDYKWAL-PDQMAQAGFYHQPSSSGE 285
             |.:.:.             ::....|..|..:|..||.  |...: |..:::|||..   :..:
Human   133 GNIAKYDIRVKNLKSRLRGGKMRYQEEEARLASFRNWPF--YVQGISPCVLSEAGFVF---TGKQ 192

  Fly   286 DRAMCFTCSVCLVCWEKTDEPWSEHERHSPLCPFVKG-----EYTQNVPLSITYATNPALPAPGL 345
            |...||:|..||..||:.|:||.||.:..|.|.|::.     |.||.:.   :|.          
Human   193 DTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLRSKKSSEEITQYIQ---SYK---------- 244

  Fly   346 GFDIISNSDYANVLCTSCSQTGELSVWSIERHLKLMHTFHVPTLLNYIFEE----SF-EWARVTA 405
            ||..|:...:.|             .| ::|.|.:...:...::  :.:||    || :|.|.:|
Human   245 GFVDITGEHFVN-------------SW-VQRELPMASAYCNDSI--FAYEELRLDSFKDWPRESA 293

  Fly   406 ICVLPNARA---RTKVNYVYSAANYGGSGSSNGAGC----NSGLNAVSGGKFGSVNA---QHITS 460
            :.|...|:|   .|.:..:....:.|        ||    ..|.:.:........|.   |::.|
Human   294 VGVAALAKAGLFYTGIKDIVQCFSCG--------GCLEKWQEGDDPLDDHTRCFPNCPFLQNMKS 350

  Fly   461 TSTLRAGVVGSKIVLGVSVRQSSGELALRMVVLNIVEVDRNSESSTSVSNDSGSVSSGGGQLMKS 525
            ::.:...:            ||.|||.      .::|       :||.||...|::.|       
Human   351 SAEVTPDL------------QSRGELC------ELLE-------TTSESNLEDSIAVG------- 383

  Fly   526 SSPMVNVSAENNATVTQVNLESKDDDNKAMTPYEKFADGFDSNGFVSALMTYNKNNGVSQN--TD 588
              |:|...|:..|...|   |:|:.:.:....|            .||...:.....:|.:  ||
Human   384 --PIVPEMAQGEAQWFQ---EAKNLNEQLRAAY------------TSASFRHMSLLDISSDLATD 431

  Fly   589 DASALYDFDLCTLSQILDHNLEEPLSL--MVGSSNTVNVSNIGMGNEINKLVVDVEISHQNNNNN 651
            .   |...||...|:.:...::|||.|  :.|:.|:|                            
Human   432 H---LLGCDLSIASKHISKPVQEPLVLPEVFGNLNSV---------------------------- 465

  Fly   652 NNNNNEASSLGGNSSNNNNNIMINGGTNSSIDKMTAIEEIDCVVESWTSVKRMNALDGASSGVNG 716
                                :.:.|...|.  |...:::|..:   |.|        |....:|.
Human   466 --------------------MCVEGEAGSG--KTVLLKKIAFL---WAS--------GCCPLLNR 497

  Fly   717 VNHMDQEVIEIAEILPTTPK-------CNQLLVKLLRTKAPEAEGSKIIMATVAKEEEEEDEEQR 774
            .     :::....:..|.|.       |:|||         |.|||...|..             
Human   498 F-----QLVFYLSLSSTRPDEGLASIICDQLL---------EKEGSVTEMCV------------- 535

  Fly   775 TDESMETDNNAEGNVAAQL---LVFDYDDTEISNDYTLAMTFSRAKFPKQLCILPHFNSSPEHKD 836
                        .|:..||   ::|..||.                  |::|.:|........|:
Human   536 ------------RNIIQQLKNQVLFLLDDY------------------KEICSIPQVIGKLIQKN 570

  Fly   837 -AGSICVVCADGTVEIYSLADFQGTMVIEEEGEHFESVV------YCRNLDRLCCCSRQGGLLFY 894
             ....|::.|..|.....:..:..| ::|.:...|.:.|      :..|:.||    |:..:.| 
Human   571 HLSRTCLLIAVRTNRARDIRRYLET-ILEIKAFPFYNTVCILRKLFSHNMTRL----RKFMVYF- 629

  Fly   895 SLSDGENDSGDELLEMDDDCSTTLTQAADVSVTDGGRQLARTDLLGKTLLANESICMDAGSEAAA 959
                |:|.|                                ...:.||.|...:||         
Human   630 ----GKNQS--------------------------------LQKIQKTPLFVAAIC--------- 649

  Fly   960 IPNSSSAAQGAHVQTSPSASSAPSTNANLLAYKTADLTLEDLKVFYALTQ---FDDKLT--VYSA 1019
                      ||....|                 .|.:.:|:.||.:..:   ..:|.|  :..|
Human   650 ----------AHWFQYP-----------------FDPSFDDVAVFKSYMERLSLRNKATAEILKA 687

  Fly  1020 EVPSC--------------WNDIGQVQNQRKQSQNMRHGGDERDFTRTWRLHNDAT--------- 1061
            .|.||              :||           .::...|.:.|...|..|.:..|         
Human   688 TVSSCGELALKGFFSCCFEFND-----------DDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYR 741

  Fly  1062 ----TWDEHIIELNLAQPVSLG---HIDLKFTVYQQCSNPAAIQVTLLKQNNNGFGYRMKGPHSS 1119
                .:.|.:..:.|.:.:...   |.||.....:|.::|    :..:...||...|....|.:.
Human   742 FLSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINSP----MMTVSAYNNFLNYVSSLPSTK 802

  Fly  1120 YKPNV-------IDDNIDLSYIANENPVLSEEYLLAHNAEVLAGPIEL----------------- 1160
            ..|.:       :|:...|..|:..:..|..:..::...::|.|..::                 
Human   803 AGPKIVSHLLHLVDNKESLENISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVSEHLLVLA 867

  Fly  1161 ------SSCIDLCD-------QGGTATLTSPKLFKTRTRNFLLH------IKTVSDPSKDGQNKT 1206
                  |:.:..|.       ||.|.||.:..|     :.|..|      ::::..|.:.  |||
Human   868 LKTAYQSNTVAACSPFVLQFLQGRTLTLGALNL-----QYFFDHPESLSLLRSIHFPIRG--NKT 925

  Fly  1207 RDSPTRHKRPHHVEGFVERNKVSRNPFNVAANIISVVKTAVLEVFPAAKNACVKIIQVNKPKTQD 1271
              ||..|                   |:|........:...::...|:....:...:.|..:.:|
Human   926 --SPRAH-------------------FSVLETCFDKSQVPTIDQDYASAFEPMNEWERNLAEKED 969

  Fly  1272 NEKVFVAKIIKNKTQSQSAAVAPSVG-----RRLEQLPSRE---------GCDWLHEISISV--- 1319
            |.|.::       ...:.|:...|.|     .:..::|..|         |.|.| ||.::|   
Human   970 NVKSYM-------DMQRRASPDLSTGYWKLSPKQYKIPCLEVDVNDIDVVGQDML-EILMTVFSA 1026

  Fly  1320 -RAVKSHSRISNGRMQRI----AMLESNVLLVQLLRIASDPASSSLAKNL----SLDILNWI--- 1372
             :.::.|...|.|.::.|    .:.:::|....:.::....|...|...|    ||::...|   
Human  1027 SQRIELHLNHSRGFIESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTIQSQ 1091

  Fly  1373 --CFIRLNRFRSPKSERLKD-QINKQTAANIQDLLAQQFECISLAEKHIEQLLRNCVIYSERSTA 1434
              .|..|::|..     ||: .::.:...|:..::.::|...    .|:|:||   :..|.....
Human  1092 DQIFPNLDKFLC-----LKELSVDLEGNINVFSVIPEEFPNF----HHMEKLL---IQISAEYDP 1144

  Fly  1435 HKCVKLLIMLTEGATNLPAEVQDHTTLDYSFKAAIANTFPELPRAQCGSVVRWYMMLTCATSTAE 1499
            .|.|||:    :.:.||      |.   :..|....:.|        ||::.  |:::|...|..
Human  1145 SKLVKLI----QNSPNL------HV---FHLKCNFFSDF--------GSLMT--MLVSCKKLTEI 1186

  Fly  1500 SHNSISEQAI----SLLKEIAAEIDKRWDPHCALLCTRFGLYGYPFEPEIFDFDFPNVSRQGPGS 1560
            ..:....||:    ||...|:.:|              ..|.|..|..|.....|..:.     .
Human  1187 KFSDSFFQAVPFVASLPNFISLKI--------------LNLEGQQFPDEETSEKFAYIL-----G 1232

  Fly  1561 SVANVIRSSPTILPVTGLDIKRLSSIDGVDFRTFPYLIRGKSISNQLRGLLEVVQLHFNCVQTSE 1625
            |::|:   ...||| ||         ||: :|....:|:            :..|||  |::...
Human  1233 SLSNL---EELILP-TG---------DGI-YRVAKLIIQ------------QCQQLH--CLRVLS 1269

  Fly  1626 ATRIDNIDSV 1635
            ..:..|.|||
Human  1270 FFKTLNDDSV 1279

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BruceNP_001262460.1 BIR 251..321 CDD:279047 25/70 (36%)
DUF3643 3539..3664 CDD:289152
UQ_con 4636..4790 CDD:278603
NAIPNP_001333799.1 BIR 1 60..127 14/80 (18%)
BIR 2 159..227 25/72 (35%)
BIR 3 278..345 16/74 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1101
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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