Protein Alignment Bruce and NAIP

DIOPT Version :10

• Sequence 1: NP_001262460.1
• Gene: Bruce / 41260
• FlyBaseID: FBgn0266717
• Length: 4976
• Species: Drosophila melanogaster
• Sequence 2: NP_004527.2
• Gene: NAIP / 4671
• HGNCID: 7634
• Length: 1403
• Species: Homo sapiens
• Alignment Length: 1700
• Identity: 305/1700 - (17%)
• Similarity: 543/1700 - (31%)
• Gaps: 640/1700 - (37%)

  Fly   138 NCITELES-EGLECPCDISNELTQKINQAQLKAKKGI------KAQRWNTICLEVPYSS------ 189
            |.:.||.: .||:. ..::.||.::..:.:.|.:||.      :|:|..|.....||||
Human    18 NLLPELSALLGLDA-VQLAKELEEEEQKERAKMQKGYNSQMRSEAKRLKTFVTYEPYSSWIPQEM 81

  Fly   190 -------------LKLVSNNMVILLKRLERHIPVLAIASAINERLTDMMMGSRVPDFGW------ 235
                         ::....::::....|.| :|:     ..::|..        ||.|:
Human    82 AAAGFYFTGVKSGIQCFCCSLILFGAGLTR-LPI-----EDHKRFH--------PDCGFLLNKDV 132

  Fly   236 -NFSNFQ-------------RVLMHSEAVRRQTFEKWPHMDYKWAL-PDQMAQAGFYHQPSSSGE 285
             |.:.:.             ::....|..|..:|..||.  |...: |..:::|||..   :..:
Human   133 GNIAKYDIRVKNLKSRLRGGKMRYQEEEARLASFRNWPF--YVQGISPCVLSEAGFVF---TGKQ 192

  Fly   286 DRAMCFTCSVCLVCWEKTDEPWSEHERHSPLCPFVKG-----EYTQNVPLSITYATNPALPAPGL 345
            |...||:|..||..||:.|:||.||.:..|.|.|::.     |.||.:.   :|.
Human   193 DTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLRSKKSSEEITQYIQ---SYK---------- 244

  Fly   346 GFDIISNSDYANVLCTSCSQTGELSVWSIERHLKLMHTFHVPTLLNYIFEE----SF-EWARVTA 405
            ||..|:...:.|             .| ::|.|.:...:...::  :.:||    || :|.|.:|
Human   245 GFVDITGEHFVN-------------SW-VQRELPMASAYCNDSI--FAYEELRLDSFKDWPRESA 293

  Fly   406 ICVLPNARA---RTKVNYVYSAANYGGSGSSNGAGC----NSGLNAVSGGKFGSVNA---QHITS 460
            :.|...|:|   .|.:..:....:.|        ||    ..|.:.:........|.   |::.|
Human   294 VGVAALAKAGLFYTGIKDIVQCFSCG--------GCLEKWQEGDDPLDDHTRCFPNCPFLQNMKS 350

  Fly   461 TSTLRAGVVGSKIVLGVSVRQSSGELALRMVVLNIVEVDRNSESSTSVSNDSGSVSSGGGQLMKS 525
            ::.:...:            ||.|||.      .::|       :||.||...|::.|
Human   351 SAEVTPDL------------QSRGELC------ELLE-------TTSESNLEDSIAVG------- 383

  Fly   526 SSPMVNVSAENNATVTQVNLESKDDDNKAMTPYEKFADGFDSNGFVSALMTYNKNNGVSQN--TD 588
              |:|...|:..|...|   |:|:.:.:....|            .||...:.....:|.:  ||
Human   384 --PIVPEMAQGEAQWFQ---EAKNLNEQLRAAY------------TSASFRHMSLLDISSDLATD 431

  Fly   589 DASALYDFDLCTLSQILDHNLEEPLSL--MVGSSNTVNVSNIGMGNEINKLVVDVEISHQNNNNN 651
            .   |...||...|:.:...::|||.|  :.|:.|:|
Human   432 H---LLGCDLSIASKHISKPVQEPLVLPEVFGNLNSV---------------------------- 465

  Fly   652 NNNNNEASSLGGNSSNNNNNIMINGGTNSSIDKMTAIEEIDCVVESWTSVKRMNALDGASSGVNG 716
                                :.:.|...|.  |...:::|..:   |.|        |....:|.
Human   466 --------------------MCVEGEAGSG--KTVLLKKIAFL---WAS--------GCCPLLNR 497

  Fly   717 VNHMDQEVIEIAEILPTTPK-------CNQLLVKLLRTKAPEAEGSKIIMATVAKEEEEEDEEQR 774
            .     :::....:..|.|.       |:|||         |.|||...|..
Human   498 F-----QLVFYLSLSSTRPDEGLASIICDQLL---------EKEGSVTEMCV------------- 535

  Fly   775 TDESMETDNNAEGNVAAQL---LVFDYDDTEISNDYTLAMTFSRAKFPKQLCILPHFNSSPEHKD 836
                        .|:..||   ::|..||.                  |::|.:|........|:
Human   536 ------------RNIIQQLKNQVLFLLDDY------------------KEICSIPQVIGKLIQKN 570

  Fly   837 -AGSICVVCADGTVEIYSLADFQGTMVIEEEGEHFESVV------YCRNLDRLCCCSRQGGLLFY 894
             ....|::.|..|.....:..:..| ::|.:...|.:.|      :..|:.||    |:..:.|
Human   571 HLSRTCLLIAVRTNRARDIRRYLET-ILEIKAFPFYNTVCILRKLFSHNMTRL----RKFMVYF- 629

  Fly   895 SLSDGENDSGDELLEMDDDCSTTLTQAADVSVTDGGRQLARTDLLGKTLLANESICMDAGSEAAA 959
                |:|.|                                ...:.||.|...:||
Human   630 ----GKNQS--------------------------------LQKIQKTPLFVAAIC--------- 649

  Fly   960 IPNSSSAAQGAHVQTSPSASSAPSTNANLLAYKTADLTLEDLKVFYALTQ---FDDKLT--VYSA 1019
                      ||....|                 .|.:.:|:.||.:..:   ..:|.|  :..|
Human   650 ----------AHWFQYP-----------------FDPSFDDVAVFKSYMERLSLRNKATAEILKA 687

  Fly  1020 EVPSC--------------WNDIGQVQNQRKQSQNMRHGGDERDFTRTWRLHNDAT--------- 1061
            .|.||              :||           .::...|.:.|...|..|.:..|
Human   688 TVSSCGELALKGFFSCCFEFND-----------DDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYR 741

  Fly  1062 ----TWDEHIIELNLAQPVSLG---HIDLKFTVYQQCSNPAAIQVTLLKQNNNGFGYRMKGPHSS 1119
                .:.|.:..:.|.:.:...   |.||.....:|.::|    :..:...||...|....|.:.
Human   742 FLSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINSP----MMTVSAYNNFLNYVSSLPSTK 802

  Fly  1120 YKPNV-------IDDNIDLSYIANENPVLSEEYLLAHNAEVLAGPIEL----------------- 1160
            ..|.:       :|:...|..|:..:..|..:..::...::|.|..::
Human   803 AGPKIVSHLLHLVDNKESLENISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVSEHLLVLA 867

  Fly  1161 ------SSCIDLCD-------QGGTATLTSPKLFKTRTRNFLLH------IKTVSDPSKDGQNKT 1206
                  |:.:..|.       ||.|.||.:..|     :.|..|      ::::..|.:.  |||
Human   868 LKTAYQSNTVAACSPFVLQFLQGRTLTLGALNL-----QYFFDHPESLSLLRSIHFPIRG--NKT 925

  Fly  1207 RDSPTRHKRPHHVEGFVERNKVSRNPFNVAANIISVVKTAVLEVFPAAKNACVKIIQVNKPKTQD 1271
              ||..|                   |:|........:...::...|:....:...:.|..:.:|
Human   926 --SPRAH-------------------FSVLETCFDKSQVPTIDQDYASAFEPMNEWERNLAEKED 969

  Fly  1272 NEKVFVAKIIKNKTQSQSAAVAPSVG-----RRLEQLPSRE---------GCDWLHEISISV--- 1319
            |.|.::       ...:.|:...|.|     .:..::|..|         |.|.| ||.::|
Human   970 NVKSYM-------DMQRRASPDLSTGYWKLSPKQYKIPCLEVDVNDIDVVGQDML-EILMTVFSA 1026

  Fly  1320 -RAVKSHSRISNGRMQRI----AMLESNVLLVQLLRIASDPASSSLAKNL----SLDILNWI--- 1372
             :.::.|...|.|.::.|    .:.:::|....:.::....|...|...|    ||::...|
Human  1027 SQRIELHLNHSRGFIESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTIQSQ 1091

  Fly  1373 --CFIRLNRFRSPKSERLKD-QINKQTAANIQDLLAQQFECISLAEKHIEQLLRNCVIYSERSTA 1434
              .|..|::|..     ||: .::.:...|:..::.::|...    .|:|:||   :..|.....
Human  1092 DQIFPNLDKFLC-----LKELSVDLEGNINVFSVIPEEFPNF----HHMEKLL---IQISAEYDP 1144

  Fly  1435 HKCVKLLIMLTEGATNLPAEVQDHTTLDYSFKAAIANTFPELPRAQCGSVVRWYMMLTCATSTAE 1499
            .|.|||:    :.:.||      |.   :..|....:.|        ||::.  |:::|...|..
Human  1145 SKLVKLI----QNSPNL------HV---FHLKCNFFSDF--------GSLMT--MLVSCKKLTEI 1186

  Fly  1500 SHNSISEQAI----SLLKEIAAEIDKRWDPHCALLCTRFGLYGYPFEPEIFDFDFPNVSRQGPGS 1560
            ..:....||:    ||...|:.:|              ..|.|..|..|.....|..:.     .
Human  1187 KFSDSFFQAVPFVASLPNFISLKI--------------LNLEGQQFPDEETSEKFAYIL-----G 1232

  Fly  1561 SVANVIRSSPTILPVTGLDIKRLSSIDGVDFRTFPYLIRGKSISNQLRGLLEVVQLHFNCVQTSE 1625
            |::|:   ...||| ||         ||: :|....:|:            :..|||  |::...
Human  1233 SLSNL---EELILP-TG---------DGI-YRVAKLIIQ------------QCQQLH--CLRVLS 1269

  Fly  1626 ATRIDNIDSV 1635
            ..:..|.|||
Human  1270 FFKTLNDDSV 1279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bruce	NP_001262460.1	BIR	251..321	CDD:459891	25/70 (36%)
		BIRC6	3539..3664	CDD:463547
		UBCc_BIRC6	4631..4835	CDD:467430
NAIP	NP_004527.2	BIR	59..129	CDD:197595	14/83 (17%)
		BIR 1	60..127		14/80 (18%)
		BIR	159..229	CDD:197595	26/74 (35%)
		BIR 2	159..227		25/72 (35%)
		BIR	278..347	CDD:197595	16/76 (21%)
		BIR 3	278..345		16/74 (22%)
		NACHT	450..>766	CDD:444362	78/522 (15%)
		NACHT	464..617	CDD:428606	37/271 (14%)
		NLRC4_HD	766..872	CDD:436120	16/109 (15%)
		leucine-rich repeat	1055..1078	CDD:275380	4/22 (18%)
		leucine-rich repeat	1079..1100	CDD:275380	5/20 (25%)
		RNA1	<1150..1380	CDD:444072	40/199 (20%)
		leucine-rich repeat	1157..1182	CDD:275381	8/43 (19%)
		leucine-rich repeat	1208..1236	CDD:275381	7/46 (15%)
		leucine-rich repeat	1262..1293	CDD:275381	6/19 (32%)
		leucine-rich repeat	1294..1322	CDD:275381