DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bruce and BIRC3

DIOPT Version :9

Sequence 1:	NP_001262460.1	Gene:	Bruce / 41260	FlyBaseID:	FBgn0266717	Length:	4976	Species:	Drosophila melanogaster
Sequence 2:	NP_001156.1	Gene:	BIRC3 / 330	HGNCID:	591	Length:	604	Species:	Homo sapiens

Alignment Length:	341	Identity:	84/341 - (24%)
Similarity:	121/341 - (35%)	Gaps:	83/341 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 ASAINERLTDMMMGSRVPDFGWNFSNFQRVLMHSEAVRRQTFEKWPHMDYKWALPDQMAQAGFYH 278
            ::.:|.|...        ||.....:.....|::|..|..||:.||   ..:..|..:|:||||:
Human   143 SNPVNSRANQ--------DFSALMRSSYHCAMNNENARLLTFQTWP---LTFLSPTDLAKAGFYY 196

  Fly   279 -QPSSSGEDRAMCFTCSVCLVCWEKTDEPWSEHERHSPLCPFVKGE------YTQ---------- 326
             .|.    ||..||.|...|..||..|...|||.||.|.|||::.:      ||.
Human   197 IGPG----DRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAA 257

  Fly   327 ------NVPLSITYATNPALPAPGLGFDIISNSDYANVLCTSCSQTGELSVWSIERHLKLMHTFH 385
                  |.|.|:  ..||...| ..||..:.|||  :|.|..|.  |.|..|.......:.|...
Human   258 RFKTFFNWPSSV--LVNPEQLA-SAGFYYVGNSD--DVKCFCCD--GGLRCWESGDDPWVQHAKW 315

  Fly   386 VPTLLNYIFEESFEWARVTAICVLPNARARTKVNYVYSAANYGGSGSSNGAGCNSGLNAVSGGKF 450
            .|.....|..:..|:.|            :.:.:|.:.......:..|.|     ..||.|....
Human   316 FPRCEYLIRIKGQEFIR------------QVQASYPHLLEQLLSTSDSPG-----DENAESSIIH 363

  Fly   451 GSVNAQHITSTSTLRAGVVGSKIVLGVS---VRQ-------SSGELALRMV------VLN----I 495
            ......|......:...|:.:.:.:|.|   |:|       ::|| ..|:|      :||    |
Human   364 FEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGE-NYRLVNDLVLDLLNAEDEI 427

  Fly   496 VEVDRNSESSTSVSND 511
            .|.:|...:....|||
Human   428 REEERERATEEKESND 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bruce	NP_001262460.1	BIR	251..321	CDD:279047	30/70 (43%)
		DUF3643	3539..3664	CDD:289152
		UQ_con	4636..4790	CDD:278603
BIRC3	NP_001156.1	BIR	28..98	CDD:197595
		BIR 1	29..96
		BIR	168..237	CDD:197595	31/75 (41%)
		BIR 2	169..235		30/72 (42%)
		BIR	254..322	CDD:197595	19/74 (26%)
		BIR 3	255..322		19/73 (26%)
		UBA_like_SF	377..>411	CDD:304366	7/34 (21%)
		CARD_BIRC2_BIRC3	441..530	CDD:260038	3/3 (100%)
		zf-C3HC4_3	553..598	CDD:290631
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810