|
Fly 33 MRNVVYHPQLNVLLLFDNGSTVKVLDANSGVILQTYHLSSNGDSIVHGRYMPLQDKILFWDGHNL 97
:.::.|||.||.:|...:..|:||:|..||..||...||:.....|..:|:...||::|.|.:.:
Rat 73 LHSLSYHPALNAILAVTSRGTIKVIDGTSGATLQASALSAKPGGQVKCQYISAVDKVIFVDDYAV 137
Fly 98 GLRGDYNGVLLLDTILQAPIGQNDDYIKLEIILSEA-IIFQNCITELE---SEGLECPCDISNEL 158
|.|.|.||:|||||.||.|:.:.||.::||:.::|| .:...|:.::: :||.:. ...:|
Rat 138 GCRKDLNGILLLDTALQTPVSKQDDVVQLELPVTEAQQLLSACVEKIDVSSTEGYDL---FITQL 199
Fly 159 TQKINQAQLKAKKGIKAQRWNTICLEVPYSSLKLVSNNMVILLKRLERHIPVLAIASAINERLTD 223
...:.....:.....|..:|.|:...:|:..||.:::.:|..||::.:::..|.:||::.:||:.
Rat 200 KDGLKNTSHETAANHKVAKWATVTFHLPHHVLKSIASAIVNELKKINQNVAALPVASSVMDRLSY 264
Fly 224 MMMGSRVPDFGWN-FSNFQRVLMHSEAVRRQTFEKWPHMDYKWALPDQMAQAGFYHQPSSSGEDR 287
::..:| |:.|.. ..:..|.||:|||.||:||..|||:.|:||.||.||||||||||:|||:||
Rat 265 LLPSAR-PELGVGPGRSVDRALMYSEANRRETFTSWPHVGYRWAQPDPMAQAGFYHQPASSGDDR 328
Fly 288 AMCFTCSVCLVCWEKTDEPWSEHERHSPLCPFVKGEYTQNVPLSITYATNPA-LPAPGLGFDIIS 351
||||||||||||||.|||||||||||||.|||||||:|||||||:|.||:|| ||:.. |.|.||
Rat 329 AMCFTCSVCLVCWEPTDEPWSEHERHSPNCPFVKGEHTQNVPLSVTLATSPAQLPSAD-GADRIS 392
Fly 352 --NSDYANVLCTSCSQTGELSVWSIER----HLKLMHTFHVPTLLNYIF------------EESF 398
.|........:.::.|::.:|.:.: |||.....:.|.::..:. ..:.
Rat 393 CFGSGSCPQFLAAATKRGKICIWDVSKLMKVHLKFEINAYDPVIVQQLILSGDPSSGVDSRRPTL 457
Fly 399 EWARVTAICV-LPNARARTKVNYVYSAANYGGSGSSNGAGCNSGLNAVSGGKFGSVNAQHITSTS 462
.|...::.|. :|... |.:..|...|..:..| .:..:|..:
Rat 458 AWLEDSSSCSDIPKLE-----------------------GDSDDLLEDSDSEEHS-RSDSVTGHT 498
Fly 463 TLRAGVVGSKIVLGVSVRQSSGELALRMVVLNIVE---------------VDRNSESSTSVSNDS 512
:.:..:..|..:..:|:.|...:|... :|.|::| .:..||.:.....:.
Rat 499 SQKEAMEVSLDITALSILQQPEKLQWE-IVANVLEDTVKDLEELGANPCLTNSKSEKTKEKHQEQ 562
Fly 513 GSVS-----SGGGQLMKSSSPMVNVSAEN--------NATVTQVNLESKDDDNKAMTPYE----- 559
.::. :|| |:...||..:..:.| :.|..:...|....||::.|..|
Rat 563 HNIPFPCLLAGG--LLTYKSPATSPISSNSHRSLDGLSRTQGESISEQGSTDNESCTNSELNSPL 625
Fly 560 -----------KFADGFDSNGFVSALMTYNKNNGVSQNTDDASALYDFDLCTLSQILDHNLEEPL 613
...:..:..|.:.:.| ||.:|::..| |..|:.||::..|:...
Rat 626 VRRTLPVLLLYSIKESDEKAGKIFSQM----NNIMSKSLHD-------DGFTVPQIIEMELDNQE 679
Fly 614 SLMVGSSNTVNVSNIGMGNEINKLVVDVEISHQNNNNNNNNNNEASSLGGNSSNNNNNIMINGGT 678
.|::.......:.... :.|:||....|...|::....||
Rat 680 QLLLQDPPVTYIQQFA--------------------------DAAASLTSPDSEKWNSVFPKPGT 718
Fly 679 --------------NSSIDKMTAIEE--------IDCVVESWTSVKRMNALDGAS---------- 711
...||.:|...: ..|.|||.:::.::.||:..:
Rat 719 LVQCLRLPKFAEEETLCIDSITPCADGVHLLVGLRTCSVESLSAINQVEALNNLNKLNSALCNRR 783
Fly 712 --------SGVNGVN-----HMDQEVIEIAEILPTTPKCNQLL---------------------- 741
:.|||.| | :...::...|...|:...|.
Rat 784 KGDLESNLAVVNGANISVIQH--ESPADVPAPLIIQPEQRNLSGGYLVLYKMNYTTRIVTLEEEP 846
Fly 742 VKLLRTKAP-EAEGSKIIMATVAKEEEEEDEEQRTDESMETDNNAEGNVAAQLLVFDYDDTEISN 805
||:...|.| :...|.|::.....:..|:|.|:..:|...|..|.
Rat 847 VKIQHIKDPQDTITSLILLPPDILDNREDDCEEPAEEMQLTSKNG-------------------- 891
Fly 806 DYTLAMTFSRAKFPKQLCILPHFNSSPEHKDAGSICVVCADGTVEIYSLADFQGTMVIE------ 864
..|.| ..:....|.:.|....|.|::..|::|:....:|
Rat 892 -------IEREK-------------KSDVSTLGHLVVTTQGGYVKVLDLSNFEILAKVEPPKKEG 936
Fly 865 -EEGEHFESVVYCRNLDRLCCCSRQGGLLFYSLSDGENDSGDELLEMDDDCSTTLTQAADVSVTD 928
|:.:.|.||:||...||||.|::.|.|.|..:. |..|..|| ||:.| |
Rat 937 TEDQDTFVSVIYCSGTDRLCACTKGGELHFLQIG-GTCDDIDE---------------ADILV-D 984
Fly 929 GGRQLARTDLLGKTLLANESICMDAGSEAAAIPNSSSAAQGAHVQTSPSASSAPSTNANLLAYKT 993
|. :..|.| .:.:|:...::| ||...:..:||. .
Rat 985 GS--------------------LSKGIE--------PSLEGSRPLSNP--SSPGISGVDLLV--D 1017
Fly 994 ADLTLEDLKVFYALTQFDDKLTVYSAEVPSCWNDIGQVQNQRKQSQNM--RHGGDERDFTRTWRL 1056
...|||.|.....||:|:.....:||.||.||.::.|.|.||:..|:: :|.||....||||:|
Rat 1018 QPFTLEILTSLVELTRFETLTPRFSATVPPCWVEVQQEQQQRRHPQHLHQQHHGDAAQHTRTWKL 1082
Fly 1057 HNDATTWDEHIIELNLAQPVSLGHIDLKFTVYQQCSNPAAIQVTLLKQNNNGFGYRMKGPHSSYK 1121
..|:.:||||:.||.|.:...:||:|.||.:....::...|||:||:....|.| |
Rat 1083 QTDSNSWDEHVFELVLPKACMVGHVDFKFVLNSTITSVPQIQVSLLRNRAPGLG----------K 1137
Fly 1122 PNVIDDNIDLSYIANENPV-LSEE----------------YLLAHNAEVLAGPIELSSCIDLCDQ 1169
.|.: ||::....|.:.| |:|| :|..|..::|.||:.|:|.:||...
Rat 1138 ANAL--NIEVEQNGNPSLVDLNEEMHPMDVEESQCLRLCPFLEDHKEDILCGPVWLASGLDLSGH 1200
Fly 1170 GGTATLTSPKLFK----TRTRNFLLHIKTVSDPSKDGQNKTRDSPTRHKRPHHVEGFVERNKVSR 1230
.|..|||||||.| .:.|:||:|||.|||...|
Rat 1201 AGMLTLTSPKLVKGMAGGKYRSFLIHIKAVSDRGAD----------------------------- 1236
Fly 1231 NPFNVAANIISVVKTAVLEVFPAAKNACVKIIQVNKPKTQDNEKVF-----VAKIIKNKTQSQSA 1290
||..:.....|::..:. |...|.: :||:...|.:|.:.
Rat 1237 ------------------EVCSSGLRPVVRLPSLK----QQGHKGYSLASLLAKVAAGKEKSSNV 1279
Fly 1291 AVAPSVG-RRLEQLPSREGCDWLHEISISVRAVKSHSRISNGRMQRIAMLE----SNVLLVQLLR 1350
....:.| |:.|.| .|||.|.|:|:::|..|..| |...|:||.|||: ...||..|.|
Rat 1280 KNESAGGTRKSENL---RGCDLLQEVSVTIRRFKKTS-ICKERVQRCAMLQFSEFHEKLLNTLCR 1340
Fly 1351 IASDPASSSLAKNLSLDILNWICFIRLNRFRSPKSERLKDQINKQTAANIQDLLAQQFECISLAE 1415
.:.|...:..|::|.||.|.|:..:..| .|.|.:..::. ||::...|:|
Rat 1341 RSDDGLVTEHAQSLVLDTLCWLAGVHSN---GPGSSKEGNEC----------LLSKTRTCLS--- 1389
Fly 1416 KHIEQLLRNCVIYSERSTAHKCVKLLIMLTEGATNLPAEVQDHTTLDYSFKAAIAN-TFPELPRA 1479
.::|.|...:.||.||||.:.|.:........|.:....:.| .||.:.| .| ||.|
Rat 1390 ----DIVRVCFFEAGRSIAHKCARFLALCISNGKCDPYQPGFGSVL---LKALLDNMCF--LPAA 1445
Fly 1480 QCGSVVRWYMML----------TCATSTAESHNSISEQAISLLKEIAAEIDKRWDPHCALLCTRF 1534
..|..|.||.:| .|:|:.| :||..::.::..|..|..|||.||:
Rat 1446 ATGGSVYWYFVLLNYVKDEDLAACSTACA-----------ALLTAVSRQLQDRLTPLEALLQTRY 1499
Fly 1535 GLYGYPFEPEIFDFDFPNVSRQGPGSSVANVIRSSPTILPVTGLDIKRLSSIDGVDFRTFPYLIR 1599
|||..||:|.:||.:. .|||..||..|| :.|...:|.....:.| .
Rat 1500 GLYSSPFDPVLFDLEM-------SGSSCKNVYNSS---IGVQSDEIDLSDVLSG----------N 1544
Fly 1600 GKSIS--------NQLRGLLEVVQLHFNCVQTSEATRIDNID---------SVGGNTGANVIIED 1647
||..| ..|.|||||..|||.||.||:.|||:..| :|||.:...|....
Rat 1545 GKVSSCTAAEGSFTSLTGLLEVEPLHFTCVSTSDGTRIERDDAMSSFGVTPAVGGLSSGTVGEAS 1609
Fly 1648 VMMMPKQVVAKEKGEEMLNDLVNDVECLVEEMKVDENEKQEKVDYDAFGLVNGFKDKTLSSLNSV 1712
..:.....|| |..|.:.:....::::|.: |||:
Rat 1610 TALSSAAQVA-------LQSLSHAMASAEQQLQVLQ-EKQQ------------------------ 1642
Fly 1713 KQTLKEEVKKEKADIMDKLTIAKFLPKLSLLESYMQKKINEHISFDDFGKLDNW----------- 1766
|.||.:.:|.|.:.....|.|......|...: .|.:.|.
Rat 1643 -QLLKLQQQKAKLEAKLHQTTAAAAAAASAAAA--------------AGPVHNAVPSNPVAAPGF 1692
Fly 1767 ----------DGNTTPPFNLEVEAPIVCSEATSESNMSQQATSAGGNILD-DAADSEKITESLNA 1820
...|||.|......| .:||.|....::.|....|:::| .|.:.....::.|.
Rat 1693 FIHPSDVIPPTPKTTPLFMTPPLTP--PNEAVSVVINAELAQLFPGSVIDPPAVNLAAHNKNANK 1755
Fly 1821 NPCQPI----------AWHKLITPPPKQMIVIDRMHSGARRFVVLDFGQHILLTDLVIPSCDELT 1875
:...|: |.| .:.|||.|.|:|:||||||||||.||||:.|||||::||:|.:|.
Rat 1756 SRMNPLGSGLALAISHASH-FLQPPPHQSIIIERMHSGARRFVTLDFGRPILLTDVLIPTCGDLA 1819
Fly 1876 SLNIDIWCFDEETDCTRLVQVNDIQTKTLVLSDIQPAPICRYLKLTIIGRIGMSATKCKVPLGRF 1940
||:||||...||.|..|||...||.|.:|:|.|:.|.|:||::|:|:|||.|.:..:.|:|||.:
Rat 1820 SLSIDIWTLGEEVDGRRLVVATDISTHSLILHDLIPPPVCRFMKITVIGRYGSTNARAKIPLGFY 1884
Fly 1941 FGHPVVLE--------HD---GYGDQLMKYIKHPTHSLQSQIKSLNALYEDVHCRYSLASSKLMD 1994
:||..:|. || |.|:. ...| .:...:..:.||.||:.|||:||..:|..
Rat 1885 YGHTYILPWESELKLMHDPLRGEGES----ANQP--EIDQHLAMMVALQEDIQCRYNLACHRLEA 1943
Fly 1995 LLAPMRNSELSNVAHLQAFINKQREEELSGLENNNKVVSLYDECMLLQYQINVIRNVVLRLERAL 2059
||..:....|::..:.|.|:.|..: .:|.:::|.|.|.:|:.||.|:|:..|.|.||:.|:
Rat 1944 LLQSIDLPPLNSANNAQYFLRKPDK----AVEEDSRVFSAYQDCIQLQLQLNLAHNAVQRLKVAI 2004
Fly 2060 SPNSPTTTLLPGQSIPLTEDILRAASRDKLRVLSLSLVEV---LLHFSIEYGIKNILPVHQRFNA 2121
..:..|.:...| .||::..:|.::||.:...|::. |||.|..:.:..:| ...|:|
Rat 2005 GASRKTLSETSG-----PEDLIPTSSTEQLRTIVRYLLDTLLSLLHSSNGHSVPAVL--QSTFHA 2062
Fly 2122 ATAKALFNALVVYGDAQLQLATCSLLVRMCCFQPWWGDFLADTFCSLFSAQNCKAFPQDRIFFLL 2186
...:.||..|.:.|..:::|.|..|||::|..:.|||.||::....|::::....|||||:|.||
Rat 2063 QACEELFKHLCISGTPKIRLHTGLLLVQLCGGERWWGQFLSNVLQELYNSEQLLIFPQDRVFMLL 2127
Fly 2187 TYLGRRSIAMGACRSIVIDAVLKTLVKLLAPISPHYKFQSEQPSTSANAADRNAAMGTTSDLQLI 2251
:.:|:||:: .|.|::::|..|..||:|:.|.......... ..|:.:|
Rat 2128 SCIGQRSLS----NSGVLESLLNLLDNLLSPLQPELTMHRRTEG--------------VLDIPMI 2174
Fly 2252 TWLLLFLSVCLD-----DNE----RKDKSAARWDFM-----------SCEGDFT-------KARP 2289
:|:::.:|..|| ::| :|..:..:|.|: |.:|..: |.|.
Rat 2175 SWVVMLVSRLLDYVATVEDEAAAAKKPLNGNQWSFINNNLHTQSLNRSSKGGSSLDRLYSRKIRK 2239
Fly 2290 SATPNIKQLRCFK-----------KRIIQQNKYLAQPYADWGKKIYMIQNEHPGIFMELSTKSKG 2343
....:.:||...| |..||.|| |.. |.:..|...:....|...|.
Rat 2240 QLVHHKQQLNLLKAKQKALVEQMEKEKIQSNK---------GSS-YKLLVEQAKLKQATSKHFKD 2294
Fly 2344 AGPTKSTSTGGKINMGSSGLCVGGPSSSSGNTSKSAASSSSPKNQAVPGTDGERDSNFDKGLKSL 2408
....:.|:...:.|: .::...:..||:.:.:|.| |
Rat 2295 LIRLRRTAEWSRSNL----------------DTEVTTTKESPEIEPLPFT--------------L 2329
Fly 2409 RMDNIKVVIRGLFALLLEMDFDCNMDQFLLTCKVIARLVAACRPSVQLCKIVTIAQLQQLVRLSV 2473
..|....|::.|...||.|||.|:.|..|..|||:||:..|.||::.||:||...||::|:.|.|
Rat 2330 AHDRCISVVQKLVLFLLSMDFTCHADLLLFVCKVLARIANATRPTIHLCEIVNEPQLERLLLLLV 2394
Fly 2474 WNDQQH-------PWAVHAITCLLQDLL---------------------------DADKQFRDND 2504
..|... .||.:::||:|||:| |:|...:.:.
Rat 2395 GTDFNRGDISWGGAWAQYSLTCMLQDILAGELLAPVAAEAMEEGTVSDDVGATAGDSDDSLQQSS 2459
Fly 2505 V--TPTNDTPRTMEAA---------------IQETRDLFS------DYTSTASSCTEALFETLMP 2546
| ..|.|.|.|.|.| ::..:||.. |...........:|:.:..
Rat 2460 VQLLETIDEPLTHEIAGTPPLSSLEKDKEIDLELLQDLMEADIDPLDIDLEKDPLAAKVFKPISS 2524
Fly 2547 TAREFY-QEAVKYNYLPSLIECDDTEFDEMLNDIDMIERTKPVTKKESNALSKNTFNFFCKSISI 2610
|..::: .:...|||.| .:..:.| ||.|..||. .||.......|:|.
Rat 2525 TWYDYWGADYGTYNYNP------------YIGGLGM-----PVAKPPSNT-EKNGSQTVSVSVSQ 2571
Fly 2611 ALDSRLDVGLELHVETQLRRLTNRTSLDLYSSLPQVLTNEFVSPPPEAAPWP------------- 2662
|||:||:||||...|..|:.::...: .|:.|.|| |.||..:..|
Rat 2572 ALDARLEVGLEQQAELMLKMMSTLEA----DSILQALT----STPPTFSQSPSGTDDSLLGSLQP 2628
Fly 2663 -----EYLTQLWSGTEYNGDNTYVMFKRVFDSILAELHLEDTWVHLEQVLQMWLTLNCELSDKPY 2722
:.:.||.|....| |.|.::| |:|...| |.||.:||:||||:...|
Rat 2629 ANQNSQLIIQLSSVPMLN-----VCFNKLF-SMLQVHH-----VQLESLLQLWLTLSLNSS---- 2678
Fly 2723 TSG----------ITHSDVPKIPFGANAVQGLLLALAWHSDIKLRTWCLGFQCLFLACN------ 2771
:|| ...:.:|.|.....::...|..|||:.:..||||||....|.|..|
Rat 2679 SSGNKENGADIFLYNANRIPVISLNQASITSFLTVLAWYPNTLLRTWCLVLHSLTLMTNMQLNSG 2743
Fly 2772 -SLPIGDDADCTRINEAIVNDENFEKVLLRFFSGYGMSSSIITNRCA---GPTICKHLHELL--L 2830
|..||.......: :|:|.|...||::|.|| :|...||:.: |||..:.:.|.| |
Rat 2744 SSSSIGAQETTAHL---LVSDPNLIHVLVKFLSG---TSPHGTNQHSPQVGPTATQAMQEFLTRL 2802
Fly 2831 WLHSKSETSGIPCKRRLKDILLHVVLQLVQPGGSISNQQGPIDAQNQLVRDLLMMPNDKGDLNIA 2895
.:|..| .|.:...::||.::..|....|:....|||:|||.:|:...|....:...::..
Rat 2803 QVHLSS-----TCPQIFSELLLKLIHILSTERGAFQTGQGPLDAQVKLLEFTLEQNFEVVSVSTI 2862
Fly 2896 LKITESVSFLVYNNISNGERLQCQRGNENSPVGNN--FSNLFANVLGSENPNKQNAAICD----N 2954
..:.|||:|||::.|:..:::..:.|:::| ||.. |..||||:: .|.... |:|. :
Rat 2863 SAVIESVTFLVHHYITCSDKVMSRSGSDSS-VGARACFGGLFANLI---RPGDAK-AVCGEMTRD 2922
Fly 2955 SLIINLLKLSSHMVLTEMP----RQPS---EVTIPEEEELSNQSQTDETKAEQLNTEGHRSKVP- 3011
.|:.:||||.: :|.::| |:.| .:|....:.:|::.:....| :..|..:.:|
Rat 2923 QLMFDLLKLVN--ILVQLPLSSNREYSARVSMTTNTTDSVSDEEKVSGGK----DVNGSNTSIPG 2981
Fly 3012 ---CIADWVLRHFPTMKRLFGTLSQCSTNTFTMM--SSGCFFSPKSNMILD-DPQTIADAVFSLM 3070
.:||.||.:...|.::...|..|:::...|: :||...:...|.... |..::.|.:|:::
Rat 2982 SPAYVADLVLANQQIMSQILSALGLCNSSAMAMIIGASGLHLTKHENFHGGLDAISVGDGLFTIL 3046
Fly 3071 ITLNDKASHPRLVVVPICRYLEETTIPRNATLPRLPHSEPFLWYISKVLEVPAAVQTFTQLGGIQ 3135
.||:.|||...:::.||..|:....:.|..:|.....|||.||:|.:||:...|::.|..:||:|
Rat 3047 TTLSKKASTVHMMLQPILTYMACGYMGRQGSLATCQLSEPLLWFILRVLDTSDALKAFHDMGGVQ 3111
Fly 3136 IICHSLVRLNKTIINMQPGLISLIMQHLTRNTRFKRNNHVAASSACKKTTTGTGTTCPTSAQPPR 3200
:||:::|...:.|:|....::|.||:.| .|...|....|..|...:::|..
Rat 3112 LICNNMVTSTRAIVNTARSMVSTIMKFL--------------DSGPNKAVDSTLKTRILASEPDN 3162
Fly 3201 SAAQYDGLINFAPFSHIVSENDATQSAEVLI-SNPNNSHRRPRSPAWTYMFYPNETHVDLTITLP 3264
: :|:.||||...|.|.:...|.||||: :.| .|||.||.||:|:|.|.|...||||.||
Rat 3163 A----EGIHNFAPLGTITSSSPTAQPAEVLLQATP--PHRRARSAAWSYIFLPEEAWCDLTIHLP 3221
Fly 3265 TAILLKEVQLVPHTTSLASCPSAVALELSRDYGLGSIPVGAPMATTGLTCIRLKLAKAEVATSIV 3329
:|:||||:.:.||..|||:|||:|::|:|.| |:..:|:..|:.|:|||.|:::|.|||||:::.
Rat 3222 SAVLLKEIHIQPHLASLATCPSSVSVEVSAD-GVNMLPLSTPVVTSGLTYIKIQLVKAEVASAVC 3285
Fly 3330 LRLYKPKDCGNVGLVQIAVLGQTIFGNRMHGLRSPSPFIDSLATCSSPVQTAVLAAMDADSMLED 3394
|||::|:|...:||.||.:||.|.||. .|.||.::|. :..:
Rat 3286 LRLHRPRDASTLGLSQIKLLGLTAFGT------------TSSATVNNPF------------LPSE 3326
Fly 3395 DAFAKTSIGWVRILSRCF-HVAALQPDSKLADLIAAYPAAYPGFLEACCSLLNIMPMIP--SLAQ 3456
|..:||||||:|:|..|. |: |.|..::|:..|.....|:.|.:|| |.| .:..
Rat 3327 DQVSKTSIGWLRLLHHCLTHI------SDLEGMMASAAAPTANLLQTCAALL----MSPYCGMHS 3381
Fly 3457 QHLETILLKLSAYNHEISLQLLRTLLWH-----------TTPQVF----KLSSDSVCDLIYEVVT 3506
.::|.:|:|:...:..|.|:|:..||.: .:|.:| .|||||..|::|::.|
Rat 3382 PNIEVVLVKIGLQSTRIGLKLIDILLRNCAASGSDPTDLNSPLLFGRLNGLSSDSTIDILYQLGT 3446
Fly 3507 GSTEHLLDKLRVLIDWVMQLHDNYSKQA------RCN--------------NPQSGFVKVIASIL 3551
.......|:::.|:.|| .:.:|.| |.| .|....:..:|:||
Rat 3447 TQDPGTKDRIQALLKWV----SDSAKMAALKRSGRMNYMCPSSSAVEYGLLMPSPSHLHCVAAIL 3507
Fly 3552 WKVHTQQQLPE--LPLLISSSLFETCFEWVSSLEHDEPLKSSFDSLLCALCFIKPELFNQLLVKL 3614
| |:.:.|.| ||.|:...|||..|.|..||..:..||.:.|||||::|.|.|..|:.|:..:
Rat 3508 W--HSYELLVEYDLPALLDRELFELLFNWSMSLPCNVVLKKAVDSLLCSMCHIHPNYFSLLMGWM 3570
Fly 3615 GVKLEPPAR-----GQTDDSKVQSGSAWFRREGSENLSVLLQRPTFLKTLALACQSPAAVYQMLD 3674
|: :.||.: ..|||||.|..|:....:.....:.|....:.|.|||.:.|||.|:.|:||
Rat 3571 GI-IPPPVQCHHRLSMTDDSKKQDLSSSLTDDSKNAQAPLALTESHLATLASSSQSPEAIKQLLD 3634
Fly 3675 SGLPKLLAHAIYEYCMHLMPGSEPVASASTVPEDEPLANNQAAAAADDEDSSLTDFDKAEANVV- 3738
||||.||..::..:|...:..||.:| :.:.|:| ||...:.|
Rat 3635 SGLPSLLVRSLASFCFSHISYSESIA--------QSIDNSQ---------------DKLRRHHVP 3676
Fly 3739 --YNTPLLSSSNVPKVLDFFAECCAEGPMRDWLGTMQGSVFWKPLLQLLCNTHAAQFSKTLPKEQ 3801
.|...:::..|..:|.|..|......|:||||..:.:..|..||.|||::.:......|..:|
Rat 3677 QHCNKMPITADLVAPILRFLTEVGNSHIMKDWLGGSEVNPLWTALLFLLCHSGSTAGGHNLGAQQ 3741
Fly 3802 SFIR-------------------LERATINFFTRVSACHPGNQENLTSLLIGAIICKPLRFSHGV 3847
|..| :|.||:.||.:..:|||.||:.:..:|.......|.|.|...
Rat 3742 SSTRSASHSSAATTVLTTQQRTAIENATVAFFLQCISCHPNNQKLMAQVLCELFQTAPQRGSLPT 3806
Fly 3848 RPTISGFTRQMVLQLLLENEHITVSVRSQQPLQRRDTLSAVLGGISSGASTSLPVAAVNNHPARR 3912
...||||.|::.|||:||:|.:|:.::|..||.: |.|:: .:.|..||...
Rat 3807 SGNISGFVRRLFLQLMLEDEKVTMFLQSPCPLYK--------GRINA-------TSHVIQHPMFG 3856
Fly 3913 SSAHHMLFTVTTSTTCQEIM---QNCVSVFSNLVYQQPTDQRAGETSASSSGVSSATAKSSESKM 3974
:........:..|||..::: .:..|:.:.|:.:|..|:. |.:..:.
Rat 3857 AGHKFRTLHLPVSTTLSDVLDRVSDTPSITAKLISEQKDDKE----------------KKNHEEK 3905
Fly 3975 EK----SSFL-NFNNVEAGSMEFLTVGAAVAAKDKRIKDAKNQAAMNKDKETQTSSTNLASNIFN 4034
|| :.|. |::.|.|..::..: ..||::...|....:.:|..:|...| :||.:.|:.|..
Rat 3906 EKVKADNGFQDNYSVVVASGLKSQS-KRAVSSTPPRPPSRRGRAIPDKIGST-SSSADTANKIIT 3968
Fly 4035 VDEFLLQSANAVNGNQLVIPEYSDIVLAG-----DATISQVLASLQNAGHSLSTPCISFDLVLQQ 4094
|..|.|... :||| :.|::|:|..|.: ..|.....|.||.::.
Rat 3969 VPVFHLFHR----------------LLAGQPLPAEMTLAQLLTLLYD--RKLPQGYRSIDLTVKL 4015
Fly 4095 RSDDTSEAKKTK-----------------AACTE-----------------------PLPSPLQR 4119
.|...::...:| .:|.| |:.||||.
Rat 4016 GSKVITDPSLSKTDSFKRLHPEKDHGELIGSCPEDEALTPSDECMDGVLDESLLETCPIQSPLQV 4080
Fly 4120 FSSSGGLSLLAHYLPTVYPEHSGRKTTLVFS----EKEKSPPLSDWVKLEPNDE-IYEDLEDTLC 4179
|:..|||:|:|..||.:|||...:.:..|.: ||.|.....:||.:|.:.| :||..|....
Rat 4081 FAGMGGLALIAERLPMLYPEVIQQVSAPVVASTTQEKPKDSDQFEWVTIEQSGELVYEAPETIAA 4145
Fly 4180 EP----AAKLATVSSVPQHSLAAFGLFLRLPAYSDVLLRDKMRAQCLLRLVLGVTGDGDGNDIYS 4240
|| :|..|| |.:|.|||||||||||||.|::|||:::..||||||||||||.||:|:.|..
Rat 4146 EPPPVKSAVQAT-SPIPAHSLAAFGLFLRLPGYAEVLLKERKHAQCLLRLVLGVTDDGEGSHILQ 4209
Fly 4241 LSLAPSLPTLPFEVFRQLLDSVPLSTDDGVLLRRVVIEVGAMHLVLNCLGIFSHQSHNNRIGAPI 4305
...|..||||||.|.|.|..:.||:|||||||||:.:|:||:||:|.||...|| |..|:
Rat 4210 SPSANVLPTLPFHVLRSLFSATPLTTDDGVLLRRMALEIGALHLILVCLSALSH--HAPRV---- 4268
Fly 4306 SEPSPSGTSSGSGTIGNGSGNGSVSGTKTNAPEEATPSATSDDKSHMYWAKGTGFGTGSTTQSWN 4370
.|.|::.|:........| ||.::..:|||||||||||||...|:
Rat 4269 -------------------PNSSLNQTEPQVSNSHNP--TSTEEQQLYWAKGTGFGTGSTASGWD 4312
Fly 4371 VEQALLRQKSEEEHVTVLLLVLASYINPGDCIPSEMCGEDILAYHDVRDVTGELPPIFQTLLQQS 4435
|||||.:|:.||||||.||.|||||||| :.|.:.||..::.......:..||.:...||.||
Rat 4313 VEQALTKQRLEEEHVTCLLQVLASYINP---MSSAVNGEAQVSPESRAQNSSALPSVLLELLSQS 4374
Fly 4436 CLIPALSSYLRNDSVLDITRHIPLYRAILKLLRALSLSKMLVSLLQPSASGSGDS--------TP 4492
|||||:|||||||||||:.||:|||||:|:||||::....:|.||.|.::.:|:. ..
Rat 4375 CLIPAMSSYLRNDSVLDMARHVPLYRALLELLRAIASCTSMVPLLLPLSTENGEEEEEEQSECQT 4439
Fly 4493 PIVELLTSMKTCVDTYAKRLKVNKKSNIKGQTHQLTFNIDDGDDEGLALLIPDIHETSVLVQKTT 4557
.:..||..||||||||..||: :|:.|||..... :..|.:.|||.||:|||..|:.:|...|
Rat 4440 SVGTLLAKMKTCVDTYTNRLR-SKRENIKTGVKP---DAPDQEPEGLTLLVPDIQRTAEIVHAAT 4500
Fly 4558 DADALINMLHTNED-------GSAQLEPQS----KSIEQRYLELMKKRQFDTFDMIVESDNNSFR 4611
.|:...|:: ....::|:. ||:|::|:.:||..|||||:|:.|.|:....
Rat 4501 -----TNLRQANQEKKLGEYSKKVAMKPKPLSVLKSLEEKYVAVMKTLQFDTFEMVSEDDDGKLG 4560
Fly 4612 FVVSHHFEKMVRLAGDRYHPSRVKRLAQEAVTLSTSLPLSFSSSVFVRCDTDRLDIMKVLITGPA 4676
|.|::|:...|:.|.|....:|.:||||||||||||||||.|||||||||.:|||||||||||||
Rat 4561 FKVNYHYMSQVKNANDANSAARARRLAQEAVTLSTSLPLSSSSSVFVRCDEERLDIMKVLITGPA 4625
Fly 4677 DTPYANGCFEFDVFFPPDYPNQPMLINLETTGRHSVRFNPNLYNDGKVCLSVLNTWHGRPEEKWN 4741
|||||||||||||:||.|||:.|.|:||||||.||||||||||||||||||:|||||||||||||
Rat 4626 DTPYANGCFEFDVYFPQDYPSSPPLVNLETTGGHSVRFNPNLYNDGKVCLSILNTWHGRPEEKWN 4690
Fly 4742 AQTSSFLQVLVSIQSLILVPEPYFNEPGFERSRGSPSGTNSSREYNSNIYQACVRWAMLEQIRSP 4806
.|||||||||||:||||||.||||||||:|||||:||||.|||||:.||.||.|:||||||||:|
Rat 4691 PQTSSFLQVLVSVQSLILVAEPYFNEPGYERSRGTPSGTQSSREYDGNIRQATVKWAMLEQIRNP 4755
Fly 4807 SQCFKDVIHKHFWLKREEICAQIEGWIEELGKPQYTERASRTISFNSMVLRRHYRHLREELSKLK 4871
|.|||:||||||:|||.|:.||.|.||.::.:....:|..||:|.::..|:||...|||||.||.
Rat 4756 SPCFKEVIHKHFYLKRVEVMAQCEEWIADIQQYSSDKRVGRTMSHHAAALKRHTAQLREELLKLP 4820
Fly 4872 PPRGLEDLDAPFNPVATLPPMDVSAVAPSLAAT 4904
.|:||:. |:...:|...||
Rat 4821 CPQGLDP--------------DIEDASPVCRAT 4839
| 
