DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Bruce and Naip5

DIOPT Version :9

Sequence 1:NP_001262460.1 Gene:Bruce / 41260 FlyBaseID:FBgn0266717 Length:4976 Species:Drosophila melanogaster
Sequence 2:NP_035000.2 Gene:Naip5 / 17951 MGIID:1298220 Length:1403 Species:Mus musculus


Alignment Length:1596 Identity:294/1596 - (18%)
Similarity:503/1596 - (31%) Gaps:535/1596 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   245 MHSEAVRRQTFEKWPHMDYKWALPDQMAQAGFYHQPSSSGEDRAMCFTCSVCLVCWEKTDEPWSE 309
            |.|||.|.:|||.:... ..|. |.:||.|||||.....|   ..||.||:.|........|...
Mouse    57 MRSEAKRLKTFETYDTF-RSWT-PQEMAAAGFYHTGVRLG---VQCFCCSLILFGNSLRKLPIER 116

  Fly   310 HERHSPLCPFVKGEYTQNVPLSITYATNPALPAPGLGFDIISNSDYANVLCTSCSQTGELSVWSI 374
            |::..|.|.|::|:                              |..|:        |:..: .:
Mouse   117 HKKLRPECEFLQGK------------------------------DVGNI--------GKYDI-RV 142

  Fly   375 ERHLKLMH----TFHVPTLLNYIFEESFEWARVTAICVLPNARARTKVNYVYSAANYGGSGSSNG 435
            :|..|::.    .:|........||:...:|..|:..||             |||.:..:|..:.
Mouse   143 KRPEKMLRGGKARYHEEEARLESFEDWPFYAHGTSPRVL-------------SAAGFVFTGKRDT 194

  Fly   436 AGCNSGLNAVSGGKFGS---------VNAQHITSTSTLRAGVVGSKIVLGVSVRQSSGELALRMV 491
            ..|.|     .||..|:         .:|:.......|::             ::||.|:|    
Mouse   195 VQCFS-----CGGSLGNWEEGDDPWKEHAKWFPKCEFLQS-------------KKSSEEIA---- 237

  Fly   492 VLNIVEVDRNSESSTSVSNDSGSVSSGGGQLMKS----SSPMVNVSAENNATVTQVNLES---KD 549
                          ..:.:..|.|...|...:||    ..|||:... |::......|..   ||
Mouse   238 --------------QYIQSYEGFVHVTGEHFVKSWVRRELPMVSAYC-NDSVFANEELRMDMFKD 287

  Fly   550 DDNKAMTPYEKFA-DGFDSNGFVSALMTYNKNNGVSQNTDDASALYD----FDLCTLSQILDHNL 609
            ...::....|... .||...|....:..::....:.:..:....:.|    |..|...|.|..:.
Mouse   288 WPQESPVGVEALVRAGFFYTGKKDIVRCFSCGGCLEKWAEGDDPMEDHIKFFPECVFLQTLKSSA 352

  Fly   610 EEPLSL-----MVGSSNTVNVSNIGMGNEINKLVVDV------------EISHQNNNN------- 650
            |...:|     :..::.|...||.|....::..|||:            .:|.|..:|       
Mouse   353 EVIPTLQSQYALPEATETTRESNHGDAAAVHSTVVDLGRSEAQWFQEARSLSEQLRDNYTKATFR 417

  Fly   651 NNNNNNEASSLGGNS---------------------------SNNNNNIMINGGTNSSIDKMTAI 688
            :.|.....||||.:.                           ||.|:.:.:.|.|.|.  |.|.:
Mouse   418 HMNLPEVCSSLGTDHLLSCDVSIISKHISQPVQEALTIPEVFSNLNSVMCVEGETGSG--KTTFL 480

  Fly   689 EEIDCVVESWTSVKRMNALDGASSGVNGVNHMDQEV--IEIAEILPTTPKCNQLLVKLLRTKAPE 751
            :.|..:   |            :||...:.:..|.|  :.::.|.|.....|.:..:||     .
Mouse   481 KRIAFL---W------------ASGCCPLLYRFQLVFYLSLSSITPDQGLANIICAQLL-----G 525

  Fly   752 AEG--SKIIMATVAKEEEEEDEEQRTDESMETDNNAEGNVAAQLLVFDYDDTEISNDYTLAMTFS 814
            |.|  |::.:::..::.:.:                        ::|      :.:||:     .
Mouse   526 AGGCISEVCLSSSIQQLQHQ------------------------VLF------LLDDYS-----G 555

  Fly   815 RAKFPKQLCILPHFNSSPEHKDAGSICVVCADGTVEIYSLADFQGTMVIEEEGEHFESVVYCRNL 879
            .|..|:.|..|...|.      ....|::.|..|..:..:..:.||.:..:|...:.:|...|..
Mouse   556 LASLPQALHTLITKNY------LSRTCLLIAVHTNRVRDIRLYLGTSLEIQEFPFYNTVSVLRKF 614

  Fly   880 ---DRLCCCSRQGGLLFYSLSDG--------------------ENDSGDELLEMDDDCSTTLTQA 921
               |.:|.    ..|:.|.:.:.                    :|.|..:..:     ..||.|:
Mouse   615 FSHDIICV----EKLIIYFIDNKDLQGVYKTPLFVAAVCTDWIQNASAQDKFQ-----DVTLFQS 670

  Fly   922 ---------------ADVSVTDGGRQLARTDLLGKTLLANESICMDAG----SEAAAIPNSSSAA 967
                           ...:|:..| |||.|.|.......|.....:||    .:...:..|...|
Mouse   671 YMQYLSLKYKATAEPLQATVSSCG-QLALTGLFSSCFEFNSDDLAEAGVDEDEKLTTLLMSKFTA 734

  Fly   968 QGAHVQTSP-SASSAPSTNANLLAYKTADLTL------EDLKVFYALTQFDDKLTVY-------- 1017
            |    :..| .....|.....|.|.:..:|..      :||.::| |.|.|..|...        
Mouse   735 Q----RLRPVYRFLGPLFQEFLAAVRLTELLSSDRQEDQDLGLYY-LRQIDSPLKAINSFNIFLY 794

  Fly  1018 -------SAEVPSCWNDIGQVQNQRKQSQNMRHGGDERDFTRTWRLHNDATTWDEHIIELNLAQP 1075
                   |...|:..:.:.|:.::::..:||   .:..|:   .:||.....|.:.:..|.|..|
Mouse   795 YVSSHSSSKAAPTVVSHLLQLVDEKESLENM---SENEDY---MKLHPQTFLWFQFVRGLWLVSP 853

  Fly  1076 VSLG-----HIDLKFTVYQQCSNPAAIQVTLLKQNNNGFGYRMKGPHSSYKPNVIDDNIDLSYIA 1135
            .|..     |:.....::...||..|.....:.|...|....::             .::|.|. 
Mouse   854 ESSSSFVSEHLLRLALIFAYESNTVAECSPFILQFLRGKTLALR-------------VLNLQYF- 904

  Fly  1136 NENPVLSEEYLLAHNAEVLAGPIELSSCIDLCDQGGTATLTSPKLFKTRTRNFLLHIKTVSDPSK 1200
            .::|   |..||..:.:|.....::||.:|...:.....|..|.:.:..|..| .||      |:
Mouse   905 RDHP---ESLLLLRSLKVSINGNKMSSYVDYSFKTYFENLQPPAIDEEYTSAF-EHI------SE 959

  Fly  1201 DGQNKTRDSPT----RHKRPHHV----EGFVERNKVSRNPFNVAANIISVVKT---------AVL 1248
            ..:|..:|...    .:.||..:    ||:.   |:|..|..:....:.|..|         .::
Mouse   960 WRRNFAQDEEIIKNYENIRPRALPDISEGYW---KLSPKPCKIPKLEVQVNNTDAADQALLQVLM 1021

  Fly  1249 EVFPAAKNACVKIIQVNKPKTQDNEKVFVAKIIKNKTQSQSAAVAPSVGR----RLEQ-----LP 1304
            |||.|:::...::.         |...|:..|......|:::....|:.|    |.||     ||
Mouse  1022 EVFSASQSIEFRLF---------NSSGFLESICPALELSKASVTKCSMSRLELSRAEQELLLTLP 1077

  Fly  1305 SREGCDW-------------LHEI----SISVRAVKSHSRISNGRMQRIAMLE---SNVLLVQLL 1349
            :.:..:.             ||:.    .:.||.        :|:...:::|.   .|:|.::.|
Mouse  1078 ALQSLEVSETNQLPEQLFHNLHKFLGLKELCVRL--------DGKPNVLSVLPREFPNLLHMEKL 1134

  Fly  1350 RIASDPAS--SSLAK-----------NLSLDILN--------------------------WICFI 1375
            .|.:...|  |.|.|           :|..|.|:                          .:.|:
Mouse  1135 SIQTSTESDLSKLVKFIQNFPNLHVFHLKCDFLSNCESLMAVLASCKKLREIEFSGRCFEAMTFV 1199

  Fly  1376 R-LNRFRSPKSERLKDQINKQTAANIQDLLAQQFECISLAEKHIEQL--LRNC--VIYSERSTAH 1435
            . |..|.|.|...|||               |||.....:||..:.|  |||.  ::.......|
Mouse  1200 NILPNFVSLKILNLKD---------------QQFPDKETSEKFAQALGSLRNLEELLVPTGDGIH 1249

  Fly  1436 KCVKLLIMLTEGATNLPA--EVQDHTTLDYSFKAAIANTFPELPRAQCGSVVRWYMMLTCATSTA 1498
            :..||::   .....||.  .:..|..||       .::..|:.||                :|:
Mouse  1250 QVAKLIV---RQCLQLPCLRVLTFHDILD-------DDSVIEIARA----------------ATS 1288

  Fly  1499 ESHNSISEQAISLLKEIAAEIDKRWDPHCALLCTRFGLYGYPFEPEIFDFDFPNVSRQGPGSSVA 1563
            .....:....||:..:|..|                   ||....:..| :.||:..       .
Mouse  1289 GGFQKLENLDISMNHKITEE-------------------GYRNFFQALD-NLPNLQE-------L 1326

  Fly  1564 NVIRSSPTILPVTGLDIKRLSSIDGVDFRTFPYLIR 1599
            |:.|:.|..:.|....:|.|    |......|.|||
Mouse  1327 NICRNIPGRIQVQATTVKAL----GQCVSRLPSLIR 1358

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BruceNP_001262460.1 BIR 251..321 CDD:279047 24/69 (35%)
DUF3643 3539..3664 CDD:289152
UQ_con 4636..4790 CDD:278603
Naip5NP_035000.2 BIR 1 60..127 25/71 (35%)
BIR 61..129 CDD:237989 25/72 (35%)
BIR 2 159..227 16/85 (19%)
BIR 162..228 CDD:366227 16/83 (19%)
BIR 3 278..345 10/66 (15%)
BIR 279..346 CDD:237989 10/66 (15%)
NACHT 464..618 CDD:368582 35/216 (16%)
NOD2_WH 688..743 CDD:375327 14/59 (24%)
NLRC4_HD 767..873 CDD:375406 21/112 (19%)
leucine-rich repeat 1055..1078 CDD:275380 6/22 (27%)
AMN1 1072..1271 CDD:187754 41/224 (18%)
leucine-rich repeat 1079..1100 CDD:275380 1/20 (5%)
leucine-rich repeat 1104..1130 CDD:275380 5/33 (15%)
leucine-rich repeat 1132..1156 CDD:275381 6/23 (26%)
leucine-rich repeat 1157..1182 CDD:275381 3/24 (13%)
leucine-rich repeat 1183..1207 CDD:275381 3/23 (13%)
leucine-rich repeat 1208..1236 CDD:275381 11/42 (26%)
leucine-rich repeat 1265..1293 CDD:275381 7/50 (14%)
leucine-rich repeat 1294..1322 CDD:275381 7/47 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1101
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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