DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bruce and Naip2

DIOPT Version :9

Sequence 1:	NP_001262460.1	Gene:	Bruce / 41260	FlyBaseID:	FBgn0266717	Length:	4976	Species:	Drosophila melanogaster
Sequence 2:	NP_001119654.1	Gene:	Naip2 / 17948	MGIID:	1298226	Length:	1447	Species:	Mus musculus

Alignment Length:	1826	Identity:	314/1826 - (17%)
Similarity:	556/1826 - (30%)	Gaps:	714/1826 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 HSEAVRRQTFEKWPHMDYKWALPDQMAQAGFYHQPSSSGEDRAMCFTCSVCLVCWEKTDEPWSEH 310
            |.|..|.::||.||...:..: |..::.|||..   :...|...||:|..||..||:.|:||.||
Mouse   157 HEEEARLESFEDWPFYAHGTS-PRVLSAAGFVF---TGKRDTVQCFSCGGCLGNWEEGDDPWKEH 217

  Fly   311 ERHSPLCPF----------------------VKGEYTQN------VPLSITYATNPALPAPGLGF 347
            .:..|.|.|                      |.||:..|      :|:...|..:.......|..
Mouse   218 AKWFPKCEFLQSKKSPEEITQYVQSYEGFLHVTGEHFVNSWVRRELPMVSAYCNDSVFANEELRM 282

  Fly   348 DIISNSDYAN--------------------VLCTSCSQTGELSVWS-----IERHLKLMHTFHVP 387
            |...:..:.:                    |.|.||.  |.:..|:     ||.|.|...
Mouse   283 DTFKDWPHESPGAVEALVKAGLFYTGKRDIVQCFSCG--GCMEKWAEGDNPIEDHTKFFP----- 340

  Fly   388 TLLNYIFEESFEWAR--VTAI---CVLPNARARTKVNYVYSAANYGGSGSSNGAGCNSGLNAVSG 447
               |.:|.::.:.:.  :.|:   |.||.|...|      |.:|:     .:.|..:|.:..||.
Mouse   341 ---NCVFLQTLKSSAEVIPALQSHCALPEAMETT------SESNH-----DDAAAVHSTVVDVSP 391

  Fly   448 GKFGSVNAQHITSTSTLRAGVVGSKIVLGVSVRQSSGELALRMVVLNIVEVDRNSESSTSVSNDS 512
            .:     ||.:...|:|            |||                  :.|:.:.|.  :...
Mouse   392 SE-----AQELEPASSL------------VSV------------------LCRDQDHSE--AQGR 419

  Fly   513 GSVSSGGGQLMKSSSPMVNVSAENNATVTQVNLESKDDDNKAMTPYEKFADGFDSNGFVSALMTY 577
            |..|||   ....|:.:....|:.......::.:.:|...||...:....:.:.|.|
Mouse   420 GCASSG---TYLPSTDLGQSEAQWLQEARSLSEQLRDTYTKATFRHMNLPEVYSSLG-------- 473

  Fly   578 NKNNGVSQNTDDASALYDFDLCTLSQILDHNLEEPLSLMVGSSNTVNVSNIGMGNEINKLVVDVE 642
                     ||...:      |.:| |:..::.:|:.   ||.....|
Mouse   474 ---------TDHLLS------CDVS-IISKHISQPVQ---GSLTIPEV----------------- 502

  Fly   643 ISHQNNNNNNNNNNEASSLGGNSSNNNNNIMINGGTNSSIDKMTAIEEIDCVVESWTSVKRMNAL 707
                                  .||.|:.:.:.|...|.  |.|.::.|..:   |
Mouse   503 ----------------------FSNLNSVMCVEGEAGSG--KTTFLKRIAFL---W--------- 531

  Fly   708 DGASSGVNGVNHMDQEV--IEIAEILPTTPKCNQLLVKLLRTKAPEAEG--SKIIMATVAKEEEE 768
               :||...:.:..|.|  :.::.|.|     .|.|.|::..:...|.|  |::.::::.::.:.
Mouse   532 ---ASGCCPLLYRFQLVFYLSLSSITP-----GQELAKIICAQLLGAGGCISEVCLSSIIQQLQH 588

  Fly   769 EDEEQRTDESMETDNNAEGNVAAQLLVFDYDDTEISNDYTLAMTFSRAKFPKQLCILPHFNSSPE 833
            :                        ::|      :.:||:     ..|..|:.|..|...|.
Mouse   589 Q------------------------VLF------LLDDYS-----GLASLPQALHTLITKNY--- 615

  Fly   834 HKDAGSICVVCADGTVEIYSLADFQGTMVIEEEGEHFESVVYCRNLDRLCCCSRQGGLLFYSLSD 898
               ....|::.|..|.::..:..:..|.:..:|...:.:|...|.|........:..:.::...:
Mouse   616 ---LSRTCLLIAVHTNKVRGIRPYLDTSLEIKEFPFYNTVSVLRKLFSHDIMRVRKFINYFGFHE 677

  Fly   899 GENDSGDELLEMDDDCSTTLTQAADVSVTDGGRQLARTDLLG--KTLLANESICMDAGSEAAAIP 961
                                                  :|.|  ||.|...::|.|...
Mouse   678 --------------------------------------ELQGIHKTPLFVAAVCTDWFK------ 698

  Fly   962 NSSSAAQGAHVQTSPSASSAPSTNANLLAYKTADLTLEDLKVFYALTQFDDKLTV--------YS 1018
                         :||                 |...:|:.:|.|..|:   |::        ..
Mouse   699 -------------NPS-----------------DQPFQDVALFKAYMQY---LSLKHKGAAKPLQ 730

  Fly  1019 AEVPSCWNDIGQVQNQ-------RKQSQNMRHGGDERDFTRTWRLHNDATT-------------W 1063
            |.|.||    ||:...       ...|.|:...|.:.|...|..|.:..|.             :
Mouse   731 ATVSSC----GQLALTGLFSSCFEFNSDNLAEAGVDEDEELTTCLMSKFTAQRLRPVYRFLGPLF 791

  Fly  1064 DEHIIELNLAQPVSLGH---IDLKFTVYQQCSNP---AAIQVTLLKQNNNGFGYRMKGPHSSYKP 1122
            .|.:..:.|.:.:|...   .||.....:|.::|   .:|..|.||       |....|.|...|
Mouse   792 QEFLAAVRLTELLSSDRQEDQDLGLYYLRQINSPLKAMSIYHTFLK-------YVSSHPSSKAAP 849

  Fly  1123 NVIDDNIDL--SYIANENPVLSEEYLLAHN-----AEVLAGPIELSS--------------CIDL 1166
            .|:...:.|  ...:.||...:|:|:..|.     .|.|.|..:||.              |::.
Mouse   850 TVVSHLLQLVDEKESLENMSENEDYMKLHPEALLWIECLRGLWQLSPESFSLFISENLLRICLNF 914

  Fly  1167 CDQGGTATLTSPKLFKTRTRNFLLHIKTVS-----DPSKDGQNKTRDSPTRHKRPHHVEG--FVE 1224
            ..:..|....||.:.:. .|...|.:|.:|     |                    |.|.  .::
Mouse   915 AHESNTVAACSPVILQF-LRGRTLDLKVLSLQYFWD--------------------HPETLLLLK 958

  Fly  1225 RNKVSRNPFNVAANI-ISVVKTAVLEVFPAA--KNACVKIIQVNKPKTQDNEKVFVAKIIKNKTQ 1286
            ..|:|.|..|....| .|:::.:..:|.|..  ::..:....:|:.:...:||..:.|..:
Mouse   959 SIKISLNGNNWVQRIDFSLIEKSFEKVQPPTIDQDYAIAFQPINEVQKNLSEKKHIIKKYE---- 1019

  Fly  1287 SQSAAVAPSVGRRLEQLPSREGCDWLHEISISVRAVKSHSRISNG------RMQRIAMLESNV-- 1343
                                   |..|:|.::         ||.|      :..:|..||..|
Mouse  1020 -----------------------DMKHQIPLN---------ISTGYWKLSPKPYKIPKLEVQVTN 1052

  Fly  1344 -------LLVQLLRIASDPASSSLAKNLSLDILNWICFIRLNRFRSPKSERLKDQINKQTAANIQ 1401
                   ||..|:.:.|  ||.|:...|| |...::..||      |..|..|..:.|.:.:.::
Mouse  1053 TGPADQALLQVLMEVFS--ASQSIEFRLS-DSSGFLESIR------PALELSKASVTKCSMSRLE 1108

  Fly  1402 DLLAQQFECISLAEKHIEQLLRNCVIYSERSTAHKCVKLLIMLTEGATNLPAEVQDHTTLDYSFK 1466
              |:::.:                             |||:.|              .||. |.:
Mouse  1109 --LSREDQ-----------------------------KLLLTL--------------PTLQ-SLE 1127

  Fly  1467 AAIANTFPELPRAQCGSVVRWYMMLTCATSTAESHNSISEQAISLLKEIAAEIDKRWDPHCALLC 1531
            .:..|..|:          :.:..|         |..:.      |||:...:|.:
Mouse  1128 VSETNQLPD----------QLFHNL---------HKFLG------LKELCVRLDSK--------- 1158

  Fly  1532 TRFGLYGYPFEPEIFDF---DFPNV----------SRQGPGSSVANVIRSSPTILPVTGLDIKRL 1583
                       |::...   :|||:          |.:...|.:..:|::||. |.|..|....|
Mouse  1159 -----------PDVLSVLPGEFPNLHHMEKLSIRTSTESDLSKLVKLIQNSPN-LHVFHLKCNFL 1211

  Fly  1584 SSIDGVDFRTFPYLIRGKSISNQLRGLLEVVQLHFN--CVQTSEATRIDNIDSVGGNTGANVIIE 1646
            |:.:              .:...|....::.::.|:  |.   ||....||
Mouse  1212 SNCE--------------PLMTVLASCKKLREIEFSGRCF---EAMTFVNI-------------- 1245

  Fly  1647 DVMMMPKQVVAKEKGEEMLNDLVNDVECLVEEMKVDENEKQEKVDYDAFGLVNGFKDKTLSSLNS 1711
                :|..|..|     :||         :.:.:..:.|..||. ..|.|.:...:...:.:.:.
Mouse  1246 ----LPNFVFLK-----ILN---------LRDQQFPDKETSEKF-AQALGSLRNLEKLFVPTGDG 1291

  Fly  1712 VKQTLKEEVKK-EKADIMDKLTIAKFLPKLSLLESYMQKKINEHISFDDFGKLDNWDGNTTPPFN 1775
            :.|..|..|:: .:...:..|..|:.|...|:||      |.:..:...|.||:|.|
Mouse  1292 IHQVAKLIVRQCLQLPCLRVLVFAETLDDDSVLE------IAKGATRGGFQKLENLD-------- 1342

  Fly  1776 LEVEAPIVCSEATSESNMSQQATSAGGNILDDAADSEKITESLNANPCQPIAWHKLITPPPKQMI 1840
                       .|....::::.......:||:..:.:.:..|.:...|..|           |.|
Mouse  1343 -----------LTLNHKITEEGYRNFFQVLDNLPNLKNLDISRHIPECIQI-----------QAI 1385

  Fly  1841 VIDRMHSGARRFVVLDFGQHILLTDLVIPSCDELTSLNIDIWCFDEETDCTRLVQVNDI-----Q 1900
            .:..:.....|                :||   ||.|.:..|..|||.    :..:||:     |
Mouse  1386 TVKALGQCVSR----------------LPS---LTRLGMLSWLLDEED----IKVINDVKERHPQ 1427

  Fly  1901 TKTLVL 1906
            :|.|.:
Mouse  1428 SKRLTV 1433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bruce	NP_001262460.1	BIR	251..321	CDD:279047	25/91 (27%)
		DUF3643	3539..3664	CDD:289152
		UQ_con	4636..4790	CDD:278603
Naip2	NP_001119654.1	BIR 1	60..127
		BIR	61..129	CDD:237989
		BIR	159..229	CDD:197595	26/73 (36%)
		BIR 2	159..227		25/71 (35%)
		BIR	277..346	CDD:197595	14/78 (18%)
		BIR 3	278..345		13/76 (17%)
		AAA	507..644	CDD:214640	31/199 (16%)
		NACHT	508..662	CDD:283404	34/216 (16%)
		LRR_RI	1106..1373	CDD:238064	65/433 (15%)
		leucine-rich repeat	1201..1226	CDD:275381	6/38 (16%)
		leucine-rich repeat	1227..1251	CDD:275381	7/44 (16%)
		leucine-rich repeat	1252..1280	CDD:275381	8/42 (19%)
		leucine-rich repeat	1281..1305	CDD:275381	3/23 (13%)
		leucine-rich repeat	1306..1337	CDD:275381	8/36 (22%)
		leucine-rich repeat	1338..1366	CDD:275381	6/46 (13%)
		leucine-rich repeat	1367..1399	CDD:275381	6/58 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810