DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bruce and Naip1

DIOPT Version :9

Sequence 1:	NP_001262460.1	Gene:	Bruce / 41260	FlyBaseID:	FBgn0266717	Length:	4976	Species:	Drosophila melanogaster
Sequence 2:	NP_032696.2	Gene:	Naip1 / 17940	MGIID:	1298223	Length:	1403	Species:	Mus musculus

Alignment Length:	1739	Identity:	318/1739 - (18%)
Similarity:	522/1739 - (30%)	Gaps:	671/1739 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 MHSEAVRRQTFEKWPHMDYKWALPDQMAQAGFYHQPSSSGEDRAMCFTCSVCLVCWEKTDEPWSE 309
            |.|||.|.:|||.:... ..|. |.:||.|||||.....|   ..||.||:.|........|...
Mouse    57 MRSEAKRLKTFETYDTF-RSWT-PQEMAAAGFYHTGVKLG---VQCFCCSLILFGNSLRKLPIER 116

  Fly   310 HERHSPLCPFVKGEYTQNVPLSITYATNPALPAPGLGFDIISNSDYANVLCTSCSQTGELSVWSI 374
            |::..|.|.|::|:...|:........:|.....|                      |:......
Mouse   117 HKKLRPECEFLQGKDVGNIGKYDIRVKSPEKMLRG----------------------GKARYHEE 159

  Fly   375 ERHLKLMHTFHVPTLLNYIFEESFE----WARVTAICVLPNARARTKVNYVYSAANYGGSGSSNG 435
            |..|                 ||||    :|..|:..||             |||.:..:|..:.
Mouse   160 EARL-----------------ESFEDWPFYAHGTSPRVL-------------SAAGFVFTGKRDT 194

  Fly   436 AGCNSGLNAVSGGKFGS---------VNAQHITSTSTLRAGVVGSKIVLGVSVRQSSGELALRMV 491
            ..|.|     .||..|:         .:|:.......|::             ::||.|:|
Mouse   195 VQCFS-----CGGSLGNWEEGDDPWKEHAKWFPKCEFLQS-------------KKSSEEIA---- 237

  Fly   492 VLNIVEVDRNSESSTSVSNDSGSVSSGGGQLMKS----SSPMVNVSAENNATVTQVNLESKDDDN 552
                          ..:....|.|...|...:.|    ..||  |||..|.:|. .|.|.:.|..
Mouse   238 --------------QYIQGYEGFVHVTGEHFVNSWVRRELPM--VSAYCNDSVF-ANEELRMDTF 285

  Fly   553 KAMTPYEKFADGFDSNGFVSALMTYNKNNGVSQNTDDASALYDFDLCTLSQ--ILDHNLEEPLSL 615
            |.. |:|   .....:..|.|.:.|....|:.|.......:   :.||...  |.:||...|
Mouse   286 KDW-PHE---SPVAVDALVRAGLFYTGKKGIVQCFSCGGCM---EKCTEGDDPIQEHNKFFP--- 340

  Fly   616 MVGSSNTVNVSNIGMGNEINKLVVDVEISHQNNNNNNNNNNEASSLGGNSSNNNNNIMINGGTNS 680
                                                                   |.:......|
Mouse   341 -------------------------------------------------------NCVFLQTPKS 350

  Fly   681 SIDKMTAIEEIDCVVESWTSVKRMNALDGASSGVNGVNHMDQEVIEIAEILPTTPKCNQLLVKLL 745
            |.:.:.|::. .|            ||..|....:..||.|
Mouse   351 SAEVIPALQS-HC------------ALPEAMETTSESNHDD------------------------ 378

  Fly   746 RTKAPEAEGSKIIMATVAKEEEEEDEEQRTDESMETDNNAEGNVAAQLLVFDYDDTEISNDYTLA 810
                |.|..|.::  .:.:.|.:..:|.|:......||                       ||.|
Mouse   379 ----PAAVHSTVV--GLGRSEAQWFQEARSLSEQLRDN-----------------------YTKA 414

  Fly   811 MTFSRAKFPKQLCILPHFNSSPEHKDAGSICVVCADGTVEIYSLADFQGTMVIEEEGEHFESVVY 875
             ||.....| ::|    .:...:|      .:.|....:..:.....||.:.|.|...:..||:.
Mouse   415 -TFRHMNLP-EVC----SSLGTDH------LIGCDVSIISKHISQPVQGALTIPEVFSNLSSVMC 467

  Fly   876 CRN---------LDRLC------CCS--RQGGLLFY-SLSDGENDSG------------------ 904
            ...         |.|:.      ||.  .:..|:|| |||....|.|
Mouse   468 VEGETGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSSITPDQGLANIICAQLLGAGGCISE 532

  Fly   905 -----------DELLEMDDDCS--TTLTQAADVSVTDGGRQLARTDLL---GKTLLANESICMDA 953
                       .::|.:.||.|  .:|.||....:|.  ..|:||.||   ....:......:|.
Mouse   533 VCLSSIIQQLQHQVLFLLDDYSGLASLPQALHTLITK--NYLSRTCLLIAVHTNRVRGIRSYLDT 595

  Fly   954 GSEAAAIPNSSSA--------------------------AQGAHVQTSPSASSAPSTNANLLAYK 992
            ..|....|.|::.                          .||.|  .:|...:|..|:   ....
Mouse   596 SLEIKEFPLSNTVYILKKFFSHNIKRLLEFMVYFGQNEDLQGIH--KTPLFVAAVCTD---WFEN 655

  Fly   993 TADLTLEDLKVFYALTQFDDKLTV--------YSAEVPSCWNDIGQVQNQ-------RKQSQNMR 1042
            .:|...:|:.:|.:..|:   |::        ..|.|.||    ||:...       ...|.::.
Mouse   656 PSDQPFQDMALFKSYMQY---LSLKHKGAAKPLQATVSSC----GQLALTGLFSSCFEFNSDDLA 713

  Fly  1043 HGGDERDFTRTWRLHNDATT-------------WDEHIIELNLAQPVSLGH---IDLKFTVYQQC 1091
            ..|.:.|...|..|.:..|.             :.|.:..:.|.:.:|...   .||.....:|.
Mouse   714 EAGVDEDEELTTCLMSKFTAQRLRPVYRFLGPLFQEFLAAMRLTELLSSDRQEDQDLGLYYLRQI 778

  Fly  1092 SNPAAIQVTLLKQNNNGFGYRMKGPHSSYKPNVIDDNIDLSYIANENPVLSEEY----LLAH--- 1149
            ::|    :..|...||...|....|.|...|.|:.   .|.::.:|..:|...|    .:.|
Mouse   779 NSP----LKALTTYNNFLKYVFSHPSSKAGPTVVS---HLLHLVDETELLENTYKNEDYVNHPPG 836

  Fly  1150 NAEVLAGPIELSSCIDLCDQGGTATLTSPKLFKTRTRNFLLHI--------KTVSDPSK------ 1200
            .:.::.|..||             .|.||:.:.:.....||.|        .||::.|.
Mouse   837 TSRIMKGLKEL-------------WLLSPEYYSSFVSEHLLRIALNFAYESNTVAECSPFILQFL 888

  Fly  1201 DGQNKT---------RDSPTRHKRPHHVEGFVERNKVSRNPFNVAANIISVVKTAVLEVFPAAKN 1256
            .|:...         ||.|........:|..:..|||.:           ||..:|:|
Mouse   889 RGRTLALKVLNLQYFRDHPESLLLVKSLEVSINGNKVPK-----------VVDYSVME------- 935

  Fly  1257 ACVKIIQVNKPKTQDNEKVFVAKIIKNKTQSQSAAVAPSVGRRLEQLPSREGCDWLHEISISVRA 1321
               |..:..:|.|.|              |..::|        .||:...|  ..|.|...::::
Mouse   936 ---KSFETLQPPTID--------------QDYASA--------FEQMKEHE--KNLSENEETIKS 973

  Fly  1322 VKS-----HSRISNGRMQ------RIAMLESNV---------LLVQLLRIASDPASSSLAKNLSL 1366
            :|:     ..:||:|..:      :|..||..|         ||..|:.:.|  ||.|:...||
Mouse   974 IKNIFPLQPPKISSGYWKLSPKPCKIPRLEVGVTNMGPADQALLQVLMEVFS--ASQSIEFRLS- 1035

  Fly  1367 DILNWICFIRLNRFRSPKSERLKDQINKQTAANIQDLLAQQFECISLAEKHIEQLLRNCVIYSER 1431
            |...::..||      |..|..|..:.|.:.:.::         :|.||:.
Mouse  1036 DSSGFLESIR------PALELSKASVTKCSMSRLE---------LSRAEQE-------------- 1071

  Fly  1432 STAHKCVKLLIMLTEGATNLPAEVQDHTTLDYSFKAAIANTFPELPRAQCGSVVRWYMMLTCATS 1496
                      ::||     ||| :|       |.:.:..|..|:          :.:..|
Mouse  1072 ----------LLLT-----LPA-LQ-------SLEVSETNQLPD----------QLFHNL----- 1098

  Fly  1497 TAESHNSISEQAISLLKEIAAEIDKRWDPHCALLCTRFGLYGYPFEPEIFDFDFPNV-------- 1553
                |..:.      |||:...:|                 |.|....:...:|||:
Mouse  1099 ----HKFLG------LKELCVRLD-----------------GKPDVLSVLPGEFPNLLHMEKLSI 1136

  Fly  1554 --SRQGPGSSVANVIRSSPTI---------------LPVTGLDIKRLSSID--GVDFRTFPYL-I 1598
              |.:...|.:..:|::||.:               |.......|:|..|:  |..|...|:: |
Mouse  1137 RTSMESDLSKLVKLIQNSPNLHVFHLKCDFLSNCDSLMAVLASCKKLREIEFSGRCFEAMPFVNI 1201

  Fly  1599 RGKSISNQLRGLLEVVQLHFNCVQTSE-----ATRIDNIDSVGGNTG------ANVIIEDVMMMP 1652
            ....||.:   :|.::...|...:|||     ...:.|::.:...||      |.:|:...:.:|
Mouse  1202 LPNFISLK---ILNLISQQFPDKETSEKFAQALGSLRNLEELLVPTGDGIHQVAKLIVRQCLQLP 1263

  Fly  1653 -KQVVAKEKGEEMLNDLVNDVECLVEEMKVDEN---EKQEKVDYDAFGLVNGFKDKTLSSLNSVK 1713
             .:|:|..        .:.|.:.::|..:|..:   :|.||:|.                  |:.
Mouse  1264 CLRVLAFH--------YILDNDSVIEIARVATSGGFQKLEKLDL------------------SMN 1302

  Fly  1714 QTLKEEVKKEKADIMD------KLTIAKFLPKLSLLESYMQKKINEHIS 1756
            ..:.||..:.....:|      .|.|.:.:|:...:::...|.:.:.:|
Mouse  1303 HKITEEGYRNFFQALDNLPNLQNLNICRHIPECIQVQATTVKALGQCVS 1351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bruce	NP_001262460.1	BIR	251..321	CDD:279047	24/69 (35%)
		DUF3643	3539..3664	CDD:289152
		UQ_con	4636..4790	CDD:278603
Naip1	NP_032696.2	BIR	61..129	CDD:237989	25/72 (35%)
		BIR 1	63..128		24/69 (35%)
		BIR	159..229	CDD:197595	21/104 (20%)
		BIR 2	162..228		19/100 (19%)
		BIR	279..346	CDD:237989	17/131 (13%)
		BIR 3	281..346		16/129 (12%)
		NACHT	464..617	CDD:283404	31/154 (20%)
		AAA	465..600	CDD:214640	28/136 (21%)
		AMN1	1072..>1191	CDD:187754	29/173 (17%)
		leucine-rich repeat	1132..1156	CDD:275381	4/23 (17%)
		leucine-rich repeat	1157..1182	CDD:275381	1/24 (4%)
		leucine-rich repeat	1183..1236	CDD:275381	13/55 (24%)
		leucine-rich repeat	1237..1261	CDD:275381	4/23 (17%)
		leucine-rich repeat	1262..1293	CDD:275381	6/38 (16%)
		leucine-rich repeat	1294..1322	CDD:275381	7/45 (16%)
		leucine-rich repeat	1323..1355	CDD:275381	5/29 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910