Protein Alignment Bruce and LOC1273766

DIOPT Version :10

• Sequence 1: NP_001262460.1
• Gene: Bruce / 41260
• FlyBaseID: FBgn0266717
• Length: 4976
• Species: Drosophila melanogaster
• Sequence 2: XP_312777.6
• Gene: LOC1273766 / 1273766
• VectorBaseID: AGAMI1_001575
• Length: 1382
• Species: Anopheles gambiae
• Alignment Length: 1387
• Identity: 284/1387 - (20%)
• Similarity: 470/1387 - (33%)
• Gaps: 417/1387 - (30%)

  Fly  3817 VSAC-HPGNQENL----------TSLLIGAIICKPLRFSHGVRPTISGFTRQMVLQL---LLENE 3867
            :.|| ||..:|.:          .:|:.|.::   .|...| |.|..|:..::.::.   ::..:
Mosquito   165 IRACWHPDGREEIIKQRKVGLADRTLMPGDVV---RRMVPG-RDTQRGYCHEITVRADLRIIGTK 225

  Fly  3868 HITVSVRSQQPLQRRDTLSAVLGGISSGASTSLPVAAVNNHPARRSSAHHMLFTVTTSTTCQEIM 3932
            ::..:|.|       |.|..:|         |:|..:.....:...|..|:...:...::|..::
Mosquito   226 YVVRNVAS-------DRLRPLL---------SMPKDSAVCLDSWVGSTKHINEKLVLKSSCGSLV 274

  Fly  3933 QNC----VSVF--SNLVYQQ---------PTDQRAGETSASSSGVSSATAKSSESKMEKSSFLNF 3982
            :.|    :.:|  .|:.:::         |..|..|..|..::|....|  |:|.|:.:.:::..
Mosquito   275 EVCPASDLGMFRDHNMRFRRGFFAEPLFYPGQQLVGLMSELANGKWLTT--SNEMKLSRKNYMLE 337

  Fly  3983 NNVEAGSMEFLTVG----AAVAAKDKRIKDAKNQAAMNKDKETQTSSTNLASNIFNVDEFLLQSA 4043
            ......|:|...|.    ..|:::|...|.::. .::.:..|..|..........|:.|..:...
Mosquito   338 RKFTVQSVELQGVSVHWQCKVSSEDLEQKLSEG-GSLQQPPEYITGEDLKRLKKLNLFESCMLQI 401

  Fly  4044 NAVNGNQLVIPEYSDIVLAGDATISQVLASLQNAGHSLSTPCISFDLVLQQRSDDTSEAKKTKAA 4108
            |..|..:|   |.:||:.:..|....:.:..:.                |...:..::||.|..|
Mosquito   402 NDKNYLKL---EDTDIIGSKQAWRKDMTSKYRE----------------QLLQESKAKAKPTSKA 447

  Fly  4109 CT---EPLPSPLQRFSSSGGLSLLAHYLPTVYPEHSGRKTTLVFSEKEKSPPLSDWVKLEPNDEI 4170
            .:   |.........|.|.|..|.|.   :...|:..:|.:...:..:..   ..|...|..:
Mosquito   448 ISGGEEEKKGGKGTKSGSAGSKLSAR---SAGKENGAQKVSTKLTSVDSD---EGWETDEEGE-- 504

  Fly  4171 YEDLEDTLCEPAAKLA---------TVSSVPQHSLAAFGLFLRLPAYSDVLLRDKMRAQCLLRLV 4226
            :.|...:.|...:|.:         .|..:.:..|||.....|.||..|.::.:   |..:....
Mosquito   505 HSDGAASSCSATSKTSPRKSPLLAKRVRKLKRRQLAAEFAGDRFPAAGDEVVTE---ALVVYSTA 566

  Fly  4227 LGVTGDGDGNDIYSLSLAPSLPTLPFEVFRQLLDSVPLSTDDGVLLRRVVIEVG----AMHLVLN 4287
            ..|..||        ::.|::|:........|        ||........:..|    |.:....
Mosquito   567 TVVWQDG--------TIEPNIPSTELRPIHHL--------DDHEFFPGDFVLAGNTDPAKNPSFR 615

  Fly  4288 CLGIFSHQSHNNRIG--------APISEPSPS--GTSSGS--------------GTI----GNGS 4324
            ..|:.....|:.|..        ...|||.||  |.|..|              |||    .|.:
Mosquito   616 DYGVIQDVDHHGRTARVKWFSTYTCTSEPQPSYNGESEVSVYDLKDHPDFQYRPGTIVIRVANFT 680

  Fly  4325 GN------GSVSGTKTNA---------------PEEATPSATSDDKSHMYWAKGTGFGTGSTTQS 4368
            |.      |.|.....|.               |::.......|.::: :|    |....|..:|
Mosquito   681 GEEGASTAGQVLDNYPNGMVKVWWVDGFVSMCWPQDIFEVGQYDSENN-FW----GSVADSDAES 740

  Fly  4369 WNVEQALLRQKSEEEHVTVLLLVLASYINPGDCIP----SEMCGEDILA-YHDVRDVTGELPPIF 4428
            |..|       :|..|.             ||..|    |.:....:.| ....|.....|..:|
Mosquito   741 WETE-------AESCHF-------------GDAEPGSPSSVVLKPQLTANLERARVAIARLEELF 785

  Fly  4429 --------QTLLQQSCLIPALSSY---LRNDSVLDITRHIPLYRAILKLLRALSLSKMLVS---L 4479
                    |.::::..|:.....:   |.|.|.......:.|...:.|.....::.:|...   |
Mosquito   786 NINPHLQNQEIMKKLMLVYKKCRFLDRLMNTSFFHERHFMGLVERVRKSNNQTTVERMQDQKNRL 850

  Fly  4480 LQPSASGSGDSTP---------------PIVELLTSMKTCVDTYAKRLKVNKKSN---------- 4519
            ...|||||..|||               .:....|.....|.:.|.||:.|..:|
Mosquito   851 FNQSASGSKTSTPTAGTPESVRPSLQQRALFSPSTPTSPAVSSPAGRLEENDNANYNVGIANMEL 915

  Fly  4520 --IKGQTHQLTFNIDDGDDEGLALLI----------------PD--IHETSVLVQKTTDADALIN 4564
              :.....::..|.||.|....:.:.                ||  ..||...:.:...:..|.:
Mosquito   916 DYVNNMCMKMNENADDVDLNNTSSVFDLATGGGGGVGAESDKPDQEDRETGEQLARECVSARLCS 980

  Fly  4565 MLHTNEDGSAQLEPQSKSIEQRY------LELMKKRQFDT------------------------- 4598
            ::      ..||....:.|.:||      .|::...:..|
Mosquito   981 LI------KGQLIKVLEEINERYGLEDPLKEIISVVELKTPTLASMPPSWTPSPVGTPDIPGSEP 1039

  Fly  4599 ------------FDMIVESDNN----SFRFV----VSHHFEKMVRLAGDRYHPSRVKRLAQEAVT 4643
                        .|.:..|.::    ||:.:    .||.|...:....:.  .|..|.:.:|...
Mosquito  1040 DPLASSSPAVAGADAVPSSPSSVPTESFQIIESAPTSHKFHLTIFQTSNA--QSFYKAVQREHWL 1102

  Fly  4644 LSTSLPLSFSSSVFVRCDTDRLDIMKVLITGPADTPYANGCFEFDVFFPPDYPNQPMLINLETTG 4708
            |.|:||    ..|:||...||||::.|:|.||..|||.:|.|.||:....|||..|.|.
Mosquito  1103 LRTALP----PGVWVRTFEDRLDLLSVMIEGPKKTPYEDGLFLFDIQLGLDYPRAPPLC------ 1157

  Fly  4709 RHSV-----RFNPNLYNDGKVCLSVLNTWHGRPEEKWNAQTSSFLQVLVSIQSLILVPEPYFNEP 4768
             |.:     |.|||||.|||||:|:|.||.||..|.| ..||:.|||:||||.||||.||||||.
Mosquito  1158 -HYISYCTDRLNPNLYEDGKVCVSLLGTWSGRGTEVW-GPTSTLLQVIVSIQGLILVAEPYFNEA 1220

  Fly  4769 GFERSRGSPSGTNSSREYNSNIYQACVRWAMLEQIRSPSQCFKDVIHKHFWLKREEICAQIEGWI 4833
            |:|:.|||..|..:||.||..:....|: :|.:.:.:|.:.|::.|..||....:.:.::::.|:
Mosquito  1221 GYEKLRGSQQGKENSRMYNEMVLLKLVQ-SMTKLMSNPPEVFREQILTHFHACGQRMYSRLKTWM 1284

  Fly  4834 EELGKPQYTERASRTISFNSMVLRRHYRHLREELSKLKPPRGLEDLDAPFNPVAT----LPPMDV 4894
                                            |||.          |....|.|:    ...:||
Mosquito  1285 --------------------------------ELSN----------DCNRQPSASDQTGTAAIDV 1307

  Fly  4895 SAVAPSLAATNTVQAQPDDAIVTDITLLGENADECEADGDAEGDGEVDDGFKGFPQEE------- 4952
            ||.|.|:.|::.                 :.|.....|..:|...      :..||.|
Mosquito  1308 SAAATSILASSE-----------------QEASSATVDYSSEASA------RAIPQPEFPLIPAS 1349

  Fly  4953 --------GLLTGEEEVVEILS 4966
                    |||.|.::.::.||
Mosquito  1350 RGFCLTLTGLLEGLQKQLQQLS 1371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bruce	NP_001262460.1	BIR	251..321	CDD:459891
		BIRC6	3539..3664	CDD:463547
		UBCc_BIRC6	4631..4835	CDD:467430	87/208 (42%)
LOC1273766	XP_312777.6	None