Protein Alignment MANBA and beta-Man

DIOPT Version :10

• Sequence 1: NP_005899.3
• Gene: MANBA / 4126
• HGNCID: 6831
• Length: 879
• Species: Homo sapiens
• Sequence 2: NP_649436.2
• Gene: beta-Man / 40524
• FlyBaseID: FBgn0037215
• Length: 908
• Species: Drosophila melanogaster
• Alignment Length: 925
• Identity: 326/925 - (35%)
• Similarity: 480/925 - (51%)
• Gaps: 132/925 - (14%)

Human    12 CGA---GTTAA----------------------ELSYSLRGNWSICNGNGSLELPG-AVPGCVHS 50
            ||.   |||.|                      |||     ||:|.|.||||.:.. .:|..::|
  Fly     5 CGLLRNGTTGAVMVGLVCGLYVCSGQCDKVEVIELS-----NWTITNQNGSLTIANQTLPLGIYS 64

Human    51 ALFQQGLIQDSYYRFNDLNYRWVSLDNWTYSKEFKIPFEISKWQK--VNLILEGVDTVSKILFNE 113
            |...|  :.|||   ||:..|:::.||:|:|..|:  |::..:.:  :||...|:||||:|..|.
  Fly    65 AFAPQ--VLDSY---NDVGLRYLAYDNFTFSNFFQ--FDVHHFNRGHINLTFHGIDTVSEIRLNH 122

Human   114 VTIGETDNMFNRYSFDITNVVRDVNSIELRFQSAVLYAAQQSKA--HTRYQVPPDCPPLVQKGEC 176
            ..:|.|||||.|||::::::::..|.:|:..||.|:.|..::.|  ..:..|||:||.....|||
  Fly   123 QLLGRTDNMFVRYSYEVSSLLQAENFLEVEIQSPVVAALARANALKEAKKSVPPECPNERYHGEC 187

Human   177 HVNFVRKEQCSFSWDWGPSFPTQGIWKDVRIEAYNICHLNYFTFSPIYDKSAQEWNLEIESTFDV 241
            |:|.:||.|.||||||||:.|:.||||:|.:|.|.:..:...... :...:...||:.|....|.
  Fly   188 HMNMLRKMQASFSWDWGPAAPSAGIWKNVELEIYEVAVIREVDVD-VSRVNGSYWNMHIRCFLDA 251

Human   242 VSSKPVGGQVIVAIPKLQTQQTYSIELQPGKRIVELFV--NIS------------KNITVETWWP 292
            ...:...|::::          |::||.....:|:.:.  |||            .|..|.||||
  Fly   252 GGWQNFNGRLVL----------YAVELLDRPVVVDRYAIKNISHLAPVIEFDQAVPNGKVVTWWP 306

Human   293 HGHGNQTGYNMTVLF---------ELDGGLNIEKSAKVYFRTVELIEEPIKGSPGLSFYFKINGF 348
            :|:|.|..|.:....         |:.......||.:|.|||::|:|:|.....|.:|.|::||.
  Fly   307 NGYGEQKLYPLHFTLKTWLGPDGPEVRSKTKSHKSLRVGFRTLDLVEDPAPDGVGNTFLFRVNGV 371

Human   349 PIFLKGSNWIPADSFQDRVTSELLRLLLQSVVDANMNTLRVWGGGIYEQDEFYELCDELGIMVWQ 413
            .:|:||||:||:....:..|:|.:..||:|..:|:||.|||||||:||.|.||:|.|.||:::||
  Fly   372 EMFMKGSNYIPSHLLPEMQTNEQISHLLRSAKEAHMNMLRVWGGGVYESDYFYQLADSLGLLIWQ 436

Human   414 DFMFACALYPTDQGFLDSVTAEVAYQIKRLKSHPSIIIWSGNNENEEALMMNWYHISFTDRPIYI 478
            |.|||||:||.:..||.||..||.....||..|||:.|:..|||||.||:.|||...| :|..:.
  Fly   437 DMMFACAMYPVNDEFLSSVREEVRQNAMRLSHHPSVAIFVTNNENEAALVQNWYGTLF-ERDRFE 500

Human   479 KDYVTLYVKN-IRELVLAGDKSRPF-ITSSPTNGAETVAEAWVSQNPNSNYFGDVHFYDYISDCW 541
            .:|..||:.| |.||.|....|||. :.|||:||..:..:.::|.||..|..||||||||..|.|
  Fly   501 SEYRELYLANVIHELKLVSHSSRPQPLVSSPSNGKASEPDNYISSNPQDNQNGDVHFYDYTKDGW 565

Human   542 NWKVFPKARFASEYGYQSWPSFSTLEKVSSTEDWSFNSKFSLHRQHHEGGNKQMLYQAGLHFKLP 606
            :..:||:.||.||:|:||:|.....::....:|....  ...|||||..||..::.....|..||
  Fly   566 DPGIFPRPRFVSEFGFQSFPGAYAWQRSKGEDDDLLG--LITHRQHHPLGNVPVIALVERHLPLP 628

Human   607 QSTDPLRTFKDT-------IYLTQVMQAQCVKTETEFYRRSRSEIVDQQGHTMGALYWQLNDIWQ 664
                    |.:.       ||.:|:.||...|.|||.||..|    |....|||||||||||:|.
  Fly   629 --------FPENENYATALIYFSQIAQAMATKVETELYRSLR----DTPHRTMGALYWQLNDVWV 681

Human   665 APSWASLEYGGKWKMLHYFAQNFFAPLLPVGFENENT--FYIYGVSD-LHSD-YSMTLSVRVHTW 725
            ||||:|:::.|.||:|||:|::|.||:..|....::|  ..|..:.| |..| ..:.:...||.|
  Fly   682 APSWSSIDFYGNWKLLHYWARDFLAPISIVALYEKSTDSLNISLICDQLEVDPRELNVVANVHLW 746

Human   726 SSLEPVCSRVTERFVMKGGEAVCLYEE--PVSELLRRCGNCTRESCVVSFYLSADHELLSPTNYH 788
            |.|.|..|...:..:...|   ..|::  .:|:||:  |..||.:..:...|....:::|.|::
  Fly   747 SQLLPRQSTSWDVTLRPNG---VQYDKVIAISDLLQ--GEFTRTNAFLELQLRRGQDVISRTHF- 805

Human   789 FLSSPKEAVGL-------------CKAQITAIISQQGDIFVFDLETSAVAPFVWLDVGSIPGRF- 839
            |.||...|||:             | ...|.::.....|   .::....|.||:|::.. |.|:
  Fly   806 FPSSIAGAVGIEDPGLEFEIASRTC-LNTTNVVRNSVSI---SIQVKRPAVFVYLELLK-PYRYT 865

Human   840 -SDNGFLMTEKTRTI 853
             |:|||:.||....:
  Fly   866 LSENGFMQTEPMHVV 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MANBA	NP_005899.3	LacZ	44..>693	CDD:442481	264/684 (39%)
		Mannosidase_ig	700..795	CDD:465505	26/100 (26%)
		Ig_mannosidase	801..877	CDD:465483	14/55 (25%)
beta-Man	NP_649436.2	LacZ	95..>710	CDD:442481	249/640 (39%)
		Mannosidase_ig	719..808	CDD:465505	23/94 (24%)