Protein Alignment MANBA and CG15117

DIOPT Version :10

• Sequence 1: NP_005899.3
• Gene: MANBA / 4126
• HGNCID: 6831
• Length: 879
• Species: Homo sapiens
• Sequence 2: NP_725851.1
• Gene: CG15117 / 37197
• FlyBaseID: FBgn0034417
• Length: 670
• Species: Drosophila melanogaster
• Alignment Length: 757
• Identity: 145/757 - (19%)
• Similarity: 247/757 - (32%)
• Gaps: 261/757 - (34%)

Human    24 SLRGNWSICNGNGSLELPGAVPGCVHSALFQQGLIQDSYY-----------------RFNDLNYR 71
            ||.|.|:....:.:....|               ::|.:|                 .:||
  Fly    61 SLDGIWNFVRSDQANPTQG---------------VRDEWYAKELSKSRPTIPMPVPASYND---- 106

Human    72 WVSLDN--------WTYSKEFKIPFEISKWQKVNLILEGVDTVSKILFNEVTIGETDNMFNRYSF 128
             ::.||        | |.::|.:|...||.|::.|....|...:.:..|...:.:.:.....:..
  Fly   107 -ITTDNLRDHVGTVW-YDRKFFVPRSWSKDQRIWLRFGSVHYEAYVWINGQKVVKHEMGHLPFEA 169

Human   129 DITNVVR--DVNSIELRFQSAVLYAAQQSKAHTRYQVPPD-CPPLVQKGECHVNFVRKEQCSFSW 190
            ::|:::.  ..|.|.:...:|::.........|  :||.| ...:||              |:::
  Fly   170 EVTDLLSYGAENRITVMCDNALIQTTVPQGRIT--EVPNDGGMTIVQ--------------SYTF 218

Human   191 DWGPSFPTQGIWKDVRIEAYNICHLNYFTFSPIYDKSAQEWNLEIESTF-DVVSSKPVGGQVI-- 252
            |:   |...||.:.|        || |.|.....::.....||..::|. :|..|..|.|...
  Fly   219 DF---FNYAGIHRSV--------HL-YTTPRTFIEEVEVTTNLSKDATVGEVFYSVSVNGSAANE 271

Human   253 ----------------VAIPKLQTQQTYSIELQPGKRIVELFVNISKNITVETWWPHGHGNQTGY 301
                            :.:....:.|....:||         ||     .|:.|||:...::.||
  Fly   272 ADNVLQIQANLYDKDGILVANATSDQKLGGKLQ---------VN-----PVKPWWPYLMHSEPGY 322

Human   302 NMTVLFEL--------DGGLNIEKSAKVYFRTVELIEEPIKGSPGLSFYFKINGFPIFLKGSNWI 358
                |::|        |..|::.: .||..||:....:          .|.|||.|::.:|
  Fly   323 ----LYQLEIKLLATNDELLDVYR-LKVGIRTLSWNSQ----------QFLINGKPVYFRG---- 368

Human   359 PADSFQDRVTSELL-RLLLQSVVDANMNTLRVWGGGIYE------QDEFYELCDELGIMVWQDFM 416
                |.....|::. :.|..:::..:.|.|:..|...|.      .:|..:..||.|||:..:
  Fly   369 ----FGRHEDSDIRGKGLDNALMVRDFNLLKWIGANAYRTSHYPYSEESMQFADEHGIMIIDE-- 427

Human   417 FACALYPTD---QGFLDSVTAEVAYQIKRLKSHPSIIIWSGNNENEEALMMNWYHISFTDRPIYI 478
              |....|:   |..|....:.:...|.|.::|||:::||..||....             .:..
  Fly   428 --CPSVDTENFSQELLGKHKSSLEQLIHRDRNHPSVVMWSIANEPRTG-------------SVSA 477

Human   479 KDYVTLYVKNIRELVLAGDKSRPFITSSPTNGAETVAEA---WVSQNPNSNYFGDVHFYDYISD- 539
            ..|..|.....|.|    ||:||...:...:..:..|..   .:|.|..:.::.:....|.|:.
  Fly   478 DSYFELVANFTRSL----DKTRPITAAIAVSNTQDKAGRSLDIISFNRYNAWYSNAGRLDMITQN 538

Human   540 ------CWNWKVFPKARFASEYGYQSWPSFSTLEKVSSTEDWSFNSKFSLHRQHHEGGNKQMLYQ 598
                  .|| |.:.|....||||      ..|||
  Fly   539 VIDEAIAWN-KRYNKPIIMSEYG------ADTLE------------------------------- 565

Human   599 AGLHFKLPQSTDPLRTFKDTIYLTQVMQAQCVKTE---TEFYRR--SRSEIVDQQGHTMGALYWQ 658
             |||                      ||...|.:|   ||.:.|  ...:.:.::|..:|...|.
  Fly   566 -GLH----------------------MQPAYVWSEEFQTEVFSRHFKAFDELRKKGWFIGEFVWN 607

Human   659 LNDIWQAPSWASLEYGGKWK-----------MLHYFAQNFFA 689
            ..|...|.|:..:  ||..|           ..|...:.:||
  Fly   608 FADFKTAQSYTRV--GGNKKGVFTRARQPKAAAHLLRKRYFA 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MANBA	NP_005899.3	LacZ	44..>693	CDD:442481	140/737 (19%)
		Mannosidase_ig	700..795	CDD:465505
		Ig_mannosidase	801..877	CDD:465483
CG15117	NP_725851.1	Bgal_small_N	48..648	CDD:481240	145/757 (19%)