DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6293 and SLC23A2

DIOPT Version :9

Sequence 1:	NP_001262459.1	Gene:	CG6293 / 41259	FlyBaseID:	FBgn0037807	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_005107.4	Gene:	SLC23A2 / 9962	HGNCID:	10973	Length:	650	Species:	Homo sapiens

Alignment Length:	569	Identity:	253/569 - (44%)
Similarity:	364/569 - (63%)	Gaps:	12/569 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TIEDATDASKSYSQAANTPPSNEKPKPQLLYAINDNPPWYLSIFLAFQHYLTMIGAIVSIPFILT 71
            |.|:......|.::..::..|.:..:..::|.|.|.|||||.|||..|||||.....:::||:|.
Human    61 TTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAVPFLLA 125

  Fly    72 PALCMSDEDANRGIIISTMIFVTGIVTYFQATWGVRLPIVQGGTISFLVPTLAILALPQWKCPEQ 136
            .|:|:..:......:|.|:.|..||.|..|.|:|.|||:.|....:||.|..|||:|.:|||...
Human   126 DAMCVGYDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAILSLDKWKCNTT 190

  Fly   137 AVMDAMDEAE---REELWQVRMRELSGAIAVSAMVQVILGYTGLVGKILKYVTPLTIVPTVSLVG 198
            .|..|...||   .|.:|..|:||:.|||.:|::::|::|..||.|.:|||:.||||.|||:|:|
Human   191 DVSVANGTAELLHTEHIWYPRIREIQGAIIMSSLIEVVIGLLGLPGALLKYIGPLTITPTVALIG 255

  Fly   199 LTLFEHAAETASKHWGIAVGTTGMLTLFSQIMSNVPVPILAYRKGHGLEIRQFQLFRLFPVLLTI 263
            |:.|:.|.|.|.||||||:.|..::.||||...||..|:..|:...|....:.|||::||::|.|
Human   256 LSGFQAAGERAGKHWGIAMLTIFLVLLFSQYARNVKFPLPIYKSKKGWTAYKLQLFKMFPIILAI 320

  Fly   264 MIMWGLCGILTATDVFPPSHP-----SRTDVRLNVLTSAKWFYVPYPGQFGWPSVTLSGVLGMLA 323
            ::.|.||.|.|.||||||...     :|||.|..||..|.||.||||.|:|.|:|:.:||:|||:
Human   321 LVSWLLCFIFTVTDVFPPDSTKYGFYARTDARQGVLLVAPWFKVPYPFQWGLPTVSAAGVIGMLS 385

  Fly   324 GVLACTVESLSYYPTVSQMSGAHSPPLHAINRGIGTEGFGTVLAGLWGAGNGTNTFGENVGAIGV 388
            .|:|..:||:..|...:::|.|..||:|||||||..||...||.|::|.|||:.:...|:|.:|:
Human   386 AVVASIIESIGDYYACARLSCAPPPPIHAINRGIFVEGLSCVLDGIFGTGNGSTSSSPNIGVLGI 450

  Fly   389 TKIGSRRVIQWAALIMVLQGVIGKFGAIFILIPDSVVGGIFCVMFGMIIAFGLSTLQYVDLRSAR 453
            ||:|||||||..|.:|:..|:||||.|:|..:||.|:|.:||.:||||.|.|||.||::||.|:|
Human   451 TKVGSRRVIQCGAALMLALGMIGKFSALFASLPDPVLGALFCTLFGMITAVGLSNLQFIDLNSSR 515

  Fly   454 NLYILGLSIFFPMVLCRWMQKNPGAIDTGNKTVDSTLSVLLGTTILVGGVLGCLLDNIIPGTPEE 518
            ||::||.||||.:||..::::||  :.||...:|..|:|||.|.:.|||.:..:|||.|||||||
Human   516 NLFVLGFSIFFGLVLPSYLRQNP--LVTGITGIDQVLNVLLTTAMFVGGCVAFILDNTIPGTPEE 578

  Fly   519 RGLIDWANEMPLGDDNVNDGTATDYDFPLGMDAIRRWKWTYYIPFMPTY 567
            ||:..|...:..|:.:: ||..: |:.|.||:.|::::...|:|..||:
Human   579 RGIRKWKKGVGKGNKSL-DGMES-YNLPFGMNIIKKYRCFSYLPISPTF 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6293	NP_001262459.1	HCO3_cotransp	32..519	CDD:304903	233/494 (47%)
CG6293	NP_001262459.1	Xan_ur_permease	48..464	CDD:279232	199/423 (47%)
SLC23A2	NP_005107.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
SLC23A2	NP_005107.4	Xan_ur_permease	103..531	CDD:395690	202/427 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	410	1.000	Domainoid score	I686
eggNOG	1	0.900	-	-		E1_COG2233
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	507	1.000	Inparanoid score	I1340
Isobase	1	0.950	-	0	Normalized mean entropy	S4185
OMA	1	1.010	-	-		QHG61611
OrthoDB	1	1.010	-	-		D219070at33208
OrthoFinder	1	1.000	-	-		FOG0000230
OrthoInspector	1	1.000	-	-		otm41345
orthoMCL	1	0.900	-	-		OOG6_100583
Panther	1	1.100	-	-	O	PTHR11119
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1881
SonicParanoid	1	1.000	-	-		X261
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820