DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6293 and PDE135

DIOPT Version :9

Sequence 1:	NP_001262459.1	Gene:	CG6293 / 41259	FlyBaseID:	FBgn0037807	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_180219.1	Gene:	PDE135 / 817192	AraportID:	AT2G26510	Length:	551	Species:	Arabidopsis thaliana

Alignment Length:	573	Identity:	166/573 - (28%)
Similarity:	287/573 - (50%)	Gaps:	71/573 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SYSQAANT----PPSNEKPKPQLLYAINDNPPWYLSIFLAFQHYLTMIGAIVSIP-FILTPALCM 76
            |.:.|.|.    ||:.:  ...|.|.|:.||.|:.::.||||||:.|:|..|.|. .:::|   |
plant    24 SMAMARNMGTTWPPAEQ--LHHLQYCIHSNPSWHETVVLAFQHYIVMLGTTVLIANTLVSP---M 83

  Fly    77 SDEDANRGIIISTMIFVTGIVTYFQATWGVRLPIVQGGTISFLVPTLAILALPQWKCPEQAVMDA 141
            ..:..::..:|.|::|::||.|..|...|.|||.|.|.:.::::|.|:|:         :...:.
plant    84 GGDPGDKARVIQTILFMSGINTLLQTLIGTRLPTVMGVSFAYVLPVLSII---------RDYNNG 139

  Fly   142 MDEAEREELWQVRMRELSGAIAVSAMVQVILGYTGLVGKILKYVTPLTIVPTVSLVGLTLFEHAA 206
            ..::|::. ::..||.:.|::.:|:.|.:|:||....|.:::..:|:.:||.||:|.|.||
plant   140 QFDSEKQR-FRHTMRTVQGSLIISSFVNIIIGYGQAWGNLIRIFSPIIVVPVVSVVSLGLF---- 199

  Fly   207 ETASKHWGIAVGTTGMLTLFSQIMSNVPVPIL-----AYRKGHGLEIRQFQLFRLFPVLLTIMIM 266
                        ..|...|.:.:...:|:.||     .|.| |... |...:...:.:|:.:.|:
plant   200 ------------LRGFPLLANCVEIGLPMLILLIITQQYLK-HAFS-RISMILERYALLVCLAII 250

  Fly   267 WGLCGILTATDVF-----PPSHPSRTDVRLNVLTSAKWFYVPYPGQFGWPSVTLSGVLGMLAGVL 326
            |....|||.:..:     ......||| |..:::||.|..:|||.|:|.|....|.|.||....:
plant   251 WAFAAILTVSGAYNNVSTATKQSCRTD-RAFLMSSAPWIRIPYPFQWGTPIFKASHVFGMFGAAI 314

  Fly   327 ACTVESLSYYPTVSQMSGAHSPPLHAINRGIGTEGFGTVLAGLWGAGNGTNTFGENVGAIGVTKI 391
            ..:.||...:...|:::||.:||.|.::|.||.:|.|.:|.|::|:..|.....||||.:|:|:|
plant   315 VASAESTGVFFAASRLAGATAPPAHVVSRSIGLQGIGVLLEGIFGSITGNTASVENVGLLGLTRI 379

  Fly   392 GSRRVIQWAALIMVLQGVIGKFGAIFILIPDSVVGGIFCVMFGMIIAFGLSTLQYVDLRSARNLY 456
            |||||:|.:...|:...:.|||||.|..||..:..|::|::.|:::|.|:|.:|:.|..|.||:|
plant   380 GSRRVVQVSTFFMIFFSIFGKFGAFFASIPLPIFAGVYCILLGIVVAVGISFIQFTDTNSMRNMY 444

  Fly   457 ILGLSIFFPMVLCRWMQKNP-----GAIDTGNKTVDSTLSVLLGTTILVGGVLGCLLDNIIP--- 513
            ::|:|:|..:.:.::...|.     |.:.|.....:..|:.:..:..||..:|..:|||.:.
plant   445 VIGVSLFLSLSIAQYFLANTSRAGYGPVRTAGGWFNDILNTIFASAPLVATILATILDNTLEARH 509

  Fly   514 GTPEERGLIDWANEMPLGDDNVNDGTATDYDFPLGMDAIRRWKWTYYIPFMPT 566
            .:.:.||:..|........|..||   ..|..||.::.:           |||
plant   510 ASDDARGIPWWKPFQHRNGDGRND---EFYSMPLRINEL-----------MPT 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6293	NP_001262459.1	HCO3_cotransp	32..519	CDD:304903	149/505 (30%)
CG6293	NP_001262459.1	Xan_ur_permease	48..464	CDD:279232	132/426 (31%)
PDE135	NP_180219.1	HCO3_cotransp	52..505	CDD:304903	145/484 (30%)
PDE135	NP_180219.1	Xan_ur_permease	55..461	CDD:279232	133/437 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	262	1.000	Domainoid score	I473
eggNOG	1	0.900	-	-		E1_COG2233
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	291	1.000	Inparanoid score	I827
OMA	1	1.010	-	-		QHG61611
OrthoDB	1	1.010	-	-		D387031at2759
OrthoFinder	1	1.000	-	-		FOG0000230
OrthoInspector	1	1.000	-	-		otm2430
orthoMCL	1	0.900	-	-		OOG6_100583
Panther	1	1.100	-	-	O	PTHR11119
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X261
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840