DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6293 and si:dkey-106n21.1

DIOPT Version :9

Sequence 1:	NP_001262459.1	Gene:	CG6293 / 41259	FlyBaseID:	FBgn0037807	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	XP_009296238.1	Gene:	si:dkey-106n21.1 / 798958	ZFINID:	ZDB-GENE-131120-167	Length:	609	Species:	Danio rerio

Alignment Length:	590	Identity:	266/590 - (45%)
Similarity:	385/590 - (65%)	Gaps:	33/590 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TIEDATDASKSYSQAANTPPSNE-------KPKPQLLYAINDNPPWYLSIFLAFQHYLTMIGAIV 64
            |.|.:.|:|:...:....|.|:.       .|:..|:|:|:|.|||||.|.|.||||:...|.|:
Zfish    23 TFEFSADSSRDPEKIIAEPQSDSLEEGLDPSPEGNLIYSISDRPPWYLCILLGFQHYILAFGGIL 87

  Fly    65 SIPFILTPALCMSDEDANRGIIISTMIFVTGIVTYFQATWGVRLPIVQGGTISFLVPTLAILALP 129
            :||.||...||:.:.:|.:..:|||:.||:|:.|..|.|.|.||||:||||.:|:.|||||||||
Zfish    88 AIPLILAEPLCIKENNAAKSQLISTIFFVSGLCTLLQTTLGTRLPILQGGTFTFITPTLAILALP 152

  Fly   130 QWKCPEQAV---MDAMDEA----EREELWQVRMRELSGAIAVSAMVQVILGYTGLVGKILKYVTP 187
            :|:||:.:.   ::..|.|    ..:|||:||:||:.|||.|::::|::||.:||||.:||::.|
Zfish   153 KWRCPDSSADPQVNGTDPASLLVNEDELWKVRIREIQGAILVASLLQLVLGLSGLVGLVLKFIGP 217

  Fly   188 LTIVPTVSLVGLTLFEHAAETASKHWGIAVGTTGMLTLFSQIMSNVPVPILAYRKGHGLEIRQFQ 252
            |.|.||::|:||:||..|.:.:..|||||..|..::.||||.:|.|.:|::|| |....::.|:.
Zfish   218 LAIAPTINLIGLSLFIQAGQKSGAHWGIAALTVCLIFLFSQYLSKVNLPLIAY-KDKKWKVFQYP 281

  Fly   253 LFRLFPVLLTIMIMWGLCGILTATDVFPPS-----HPSRTDVRLNVLTSAKWFYVPYPGQFGWPS 312
            ||:||..|..:...|.||.:||..:..|.|     :.:|||:.|:.:.||.|||:|||||:|.|:
Zfish   282 LFKLFSALFGMCGAWLLCFLLTYFNALPSSPSEYGYKARTDINLSAVKSAAWFYLPYPGQWGVPT 346

  Fly   313 VTLSGVLGMLAGVLACTVESLSYYPTVSQMSGAHSPPLHAINRGIGTEGFGTVLAGLWGAGNGTN 377
            |::|.||||:|||||.|:||:..|...:::|||..||.|||||||..||.|.:||.|||:||||.
Zfish   347 VSMSSVLGMMAGVLASTMESIGDYYACARLSGAPPPPTHAINRGIAVEGVGCILAALWGSGNGTT 411

  Fly   378 TFGENVGAIGVTKIGSRRVIQWAALIMVLQGVIGKFGAIFILIPDSVVGGIFCVMFGMIIAFGLS 442
            ::.:|:.|:|:|::|||.|:|.|.|:|::.|:.|||.|:||.||:.|:||:|.|||||:.|.|:|
Zfish   412 SYSQNIAALGITRVGSRLVLQTAGLLMIILGLFGKFSAVFITIPEPVIGGMFLVMFGMVAAVGIS 476

  Fly   443 TLQYVDLRSARNLYILGLSIFFPMVLCRWMQKNPGAIDTGNKTVDSTLSVLLGTTILVGGVLGCL 507
            .||||||.|:|||.|||.|.|..:||..|...|||.|:||.|.:|..:.:|..|.:.:||..|.:
Zfish   477 NLQYVDLNSSRNLLILGFSTFSGLVLPTWFHSNPGMINTGVKELDQLIMILFTTHMFIGGFFGFV 541

  Fly   508 LDNIIPGTPEERGLIDWAN------EMPLGDDNVNDGTATDYDFPLGMDAIRRWKWTYYIPFMPT 566
            |||.||||.||||:..|..      :|...||:.       |:.|...:.|.|::....:||:|:
Zfish   542 LDNTIPGTEEERGIKCWRKAVHKGPQMHTTDDSC-------YNLPFCTNFIARFRLLQRLPFLPS 599

  Fly   567 YKLQK 571
            ...|:
Zfish   600 TATQE 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6293	NP_001262459.1	HCO3_cotransp	32..519	CDD:304903	244/498 (49%)
CG6293	NP_001262459.1	Xan_ur_permease	48..464	CDD:279232	210/427 (49%)
si:dkey-106n21.1	XP_009296238.1	Xan_ur_permease	72..506	CDD:279232	213/434 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	440	1.000	Domainoid score	I525
eggNOG	1	0.900	-	-		E1_COG2233
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H112955
Inparanoid	1	1.050	529	1.000	Inparanoid score	I1187
OMA	1	1.010	-	-		QHG61611
OrthoDB	1	1.010	-	-		D219070at33208
OrthoFinder	1	1.000	-	-		FOG0000230
OrthoInspector	1	1.000	-	-		otm24635
orthoMCL	1	0.900	-	-		OOG6_100583
Panther	1	1.100	-	-	LDO	PTHR11119
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1881
SonicParanoid	1	1.000	-	-		X261
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910