DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6293 and slc23a1

DIOPT Version :9

Sequence 1:	NP_001262459.1	Gene:	CG6293 / 41259	FlyBaseID:	FBgn0037807	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_001166970.1	Gene:	slc23a1 / 559435	ZFINID:	ZDB-GENE-080804-2	Length:	622	Species:	Danio rerio

Alignment Length:	590	Identity:	245/590 - (41%)
Similarity:	363/590 - (61%)	Gaps:	28/590 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EDATDASKSYSQAA---------NTPPSNEKPKP---------QLLYAINDNPPWYLSIFLAFQH 55
            |.|.:...::|..|         ..|..|.|...         .::|.|.|.|||||.|.|..||
Zfish     5 ETAEELKLTHSDGAVPAGGPEVQEMPSDNPKTSDGHQNHSASFDMIYRIEDVPPWYLCILLGLQH 69

  Fly    56 YLTMIGAIVSIPFILTPALCMSDEDANRGIIISTMIFVTGIVTYFQATWGVRLPIVQGGTISFLV 120
            |||.....:::||:|..::|:..:......::.|:....||.|..|.|:|||||:.|....:||:
Zfish    70 YLTCFSGTIAVPFLLAESMCVGQDQYTVSQLVGTIFTCVGITTLIQTTFGVRLPLFQASAFAFLI 134

  Fly   121 PTLAILALPQWKCP--EQAVMDAMDEAEREELWQVRMRELSGAIAVSAMVQVILGYTGLVGKILK 183
            |..|||.|.:||||  |:...|.........:|..|:||:.|||.||:|::|::|:.|:.|.:|.
Zfish   135 PAQAILRLDRWKCPPEEEIYGDWSLPLNTSHIWHPRIREIQGAIIVSSMIEVVIGFAGIPGFLLN 199

  Fly   184 YVTPLTIVPTVSLVGLTLFEHAAETASKHWGIAVGTTGMLTLFSQIMSNVPVPILAYRKGHGLEI 248
            .:.|||:.|||||:||::|:.|.:.|..|||:::....::.||:|.:.|...|:.::.|..|..|
Zfish   200 SIGPLTVTPTVSLIGLSVFQTAGDRAGSHWGLSLLCIFLIVLFAQYLRNWACPLPSFSKEKGCHI 264

  Fly   249 RQFQLFRLFPVLLTIMIMWGLCGILTATDVFPP-----SHPSRTDVRLNVLTSAKWFYVPYPGQF 308
            ...|:|::||:::.||::|.:|.|||.|:|.|.     .:.:|||.|.:::|.|.||..|||.|:
Zfish   265 THVQIFKMFPIIMAIMVVWLVCYILTLTNVLPDDPDLYGYKARTDARGDIMTQAPWFRFPYPCQW 329

  Fly   309 GWPSVTLSGVLGMLAGVLACTVESLSYYPTVSQMSGAHSPPLHAINRGIGTEGFGTVLAGLWGAG 373
            |.|:||::|||||.:..||..|||:..|...:::|||..||:|||||||.|||...::|||.|.|
Zfish   330 GLPTVTVAGVLGMFSATLAGIVESIGDYYACARLSGAPPPPVHAINRGIFTEGVCCIIAGLLGTG 394

  Fly   374 NGTNTFGENVGAIGVTKIGSRRVIQWAALIMVLQGVIGKFGAIFILIPDSVVGGIFCVMFGMIIA 438
            ||:.:...|:|.:|:||:|||||||:.|.||::.|.||||.|:|..:||.::||:||.:||||.|
Zfish   395 NGSTSSSPNIGVLGITKVGSRRVIQYGAGIMLILGTIGKFTALFASLPDPILGGMFCTLFGMITA 459

  Fly   439 FGLSTLQYVDLRSARNLYILGLSIFFPMVLCRWMQKNPGAIDTGNKTVDSTLSVLLGTTILVGGV 503
            .|||.||.|||.|:|||::||.|:|..::|..::..:||:|.||...:|..::|||.|.:.|||.
Zfish   460 VGLSNLQSVDLNSSRNLFVLGFSMFSGLMLPNYLDAHPGSIKTGVAELDQIITVLLTTEMFVGGF 524

  Fly   504 LGCLLDNIIPGTPEERGLIDWANEMPLGDDNVNDGTATDYDFPLGMDAIRRWKWTYYIPFMPTYK 568
            |..:|||.||||.:||||::|.:|...|...|...|   |:||:||..:|:.....|:|..||::
Zfish   525 LAFVLDNTIPGTRKERGLVEWVDEGSSGAGTVKSDT---YNFPIGMGLVRKTGCLRYLPICPTFR 586

  Fly   569 LQKQS 573
            ..|.|
Zfish   587 GFKSS 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6293	NP_001262459.1	HCO3_cotransp	32..519	CDD:304903	217/502 (43%)
CG6293	NP_001262459.1	Xan_ur_permease	48..464	CDD:279232	186/422 (44%)
slc23a1	NP_001166970.1	HCO3_cotransp	45..540	CDD:304903	217/494 (44%)
slc23a1	NP_001166970.1	Xan_ur_permease	63..490	CDD:279232	187/426 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	440	1.000	Domainoid score	I525
eggNOG	1	0.900	-	-		E1_COG2233
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	529	1.000	Inparanoid score	I1187
OMA	1	1.010	-	-		QHG61611
OrthoDB	1	1.010	-	-		D219070at33208
OrthoFinder	1	1.000	-	-		FOG0000230
OrthoInspector	1	1.000	-	-		otm24635
orthoMCL	1	0.900	-	-		OOG6_100583
Panther	1	1.100	-	-	O	PTHR11119
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1881
SonicParanoid	1	1.000	-	-		X261
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870