DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6293 and Slc23a2

DIOPT Version :9

Sequence 1:	NP_001262459.1	Gene:	CG6293 / 41259	FlyBaseID:	FBgn0037807	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_059012.2	Gene:	Slc23a2 / 50622	RGDID:	619876	Length:	647	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	250/567 - (44%)
Similarity:	367/567 - (64%)	Gaps:	10/567 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TIEDATDASKSYSQAANTPPSNEKPKPQLLYAINDNPPWYLSIFLAFQHYLTMIGAIVSIPFILT 71
            |.|:......|.::..::..|.:..:..::|.|.|.|||||.|||..|||||.....:::||:|.
  Rat    60 TTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAVPFLLA 124

  Fly    72 PALCMSDEDANRGIIISTMIFVTGIVTYFQATWGVRLPIVQGGTISFLVPTLAILALPQWKCPEQ 136
            .|:|:.|:......:|.|:.|..||.|..|.|:|.|||:.|....:||.|..|||:|.:|||...
  Rat   125 DAMCVGDDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAILSLDKWKCNTT 189

  Fly   137 AVMDAMDEAE-REELWQVRMRELSGAIAVSAMVQVILGYTGLVGKILKYVTPLTIVPTVSLVGLT 200
            .:..|...|| .|.:|..|::|:.|||.:|::::|::|..||.|.:|:|:.||||.|||:|:||:
  Rat   190 EITVANGTAELLEHIWHPRIQEIQGAIIMSSLIEVVIGLLGLPGALLRYIGPLTITPTVALIGLS 254

  Fly   201 LFEHAAETASKHWGIAVGTTGMLTLFSQIMSNVPVPILAYRKGHGLEIRQFQLFRLFPVLLTIMI 265
            .|:.|.|.|.||||||:.|..::.||||...||..|:..|:...|....:.|||::||::|.|::
  Rat   255 GFQAAGERAGKHWGIAMLTIFLVLLFSQYARNVKFPLPIYKSKKGWTAYKLQLFKMFPIILAILV 319

  Fly   266 MWGLCGILTATDVFPPS-----HPSRTDVRLNVLTSAKWFYVPYPGQFGWPSVTLSGVLGMLAGV 325
            .|.||.|.|.|||||.:     :.:|||.|..||..|.||.||||.|:|.|:|:.:||:|||:.|
  Rat   320 SWLLCFIFTVTDVFPSNSTDYGYYARTDARKGVLLVAPWFKVPYPFQWGMPTVSAAGVIGMLSAV 384

  Fly   326 LACTVESLSYYPTVSQMSGAHSPPLHAINRGIGTEGFGTVLAGLWGAGNGTNTFGENVGAIGVTK 390
            :|..:||:..|...:::|.|..||:|||||||..||...||.|::|.|||:.:...|:|.:|:||
  Rat   385 VASIIESIGDYYACARLSCAPPPPIHAINRGIFVEGLSCVLDGVFGTGNGSTSSSPNIGVLGITK 449

  Fly   391 IGSRRVIQWAALIMVLQGVIGKFGAIFILIPDSVVGGIFCVMFGMIIAFGLSTLQYVDLRSARNL 455
            :|||||||:.|.:|:..|:||||.|:|..:||.|:|.:||.:||||.|.|||.||::||.|:|||
  Rat   450 VGSRRVIQYGAALMLGLGMIGKFSALFASLPDPVLGALFCTLFGMITAVGLSNLQFIDLNSSRNL 514

  Fly   456 YILGLSIFFPMVLCRWMQKNPGAIDTGNKTVDSTLSVLLGTTILVGGVLGCLLDNIIPGTPEERG 520
            ::||.||||.:||..::::||  :.||...:|..|:|||.|.:.|||.:..:|||.|||||||||
  Rat   515 FVLGFSIFFGLVLPSYLRQNP--LVTGITGIDQVLNVLLTTAMFVGGCVAFILDNTIPGTPEERG 577

  Fly   521 LIDWANEMPLGDDNVNDGTATDYDFPLGMDAIRRWKWTYYIPFMPTY 567
            :..|...:..|:.:: ||..: |:.|.||:.|::::...|:|..||:
  Rat   578 IKKWKKGVSKGNKSL-DGMES-YNLPFGMNIIKKYRCFSYLPISPTF 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6293	NP_001262459.1	HCO3_cotransp	32..519	CDD:304903	230/492 (47%)
CG6293	NP_001262459.1	Xan_ur_permease	48..464	CDD:279232	196/421 (47%)
Slc23a2	NP_059012.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
Slc23a2	NP_059012.2	Xan_ur_permease	102..528	CDD:395690	199/425 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	431	1.000	Domainoid score	I567
eggNOG	1	0.900	-	-		E1_COG2233
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	503	1.000	Inparanoid score	I1298
OMA	1	1.010	-	-		QHG61611
OrthoDB	1	1.010	-	-		D219070at33208
OrthoFinder	1	1.000	-	-		FOG0000230
OrthoInspector	1	1.000	-	-		otm45472
orthoMCL	1	0.900	-	-		OOG6_100583
Panther	1	1.100	-	-	O	PTHR11119
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X261
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840