DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6293 and SPAC1399.01c

DIOPT Version :9

Sequence 1:	NP_001262459.1	Gene:	CG6293 / 41259	FlyBaseID:	FBgn0037807	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_593513.1	Gene:	SPAC1399.01c / 2542454	PomBaseID:	SPAC1399.01c	Length:	601	Species:	Schizosaccharomyces pombe

Alignment Length:	575	Identity:	137/575 - (23%)
Similarity:	230/575 - (40%)	Gaps:	115/575 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PPSNEKPKPQLLYAINDNPPWYLSIFLAFQHYLTMIGAIVSIPFILTPALCMSDEDANRGIIIST 89
            |.:.:|||....:::|...|..|::.|.|||.|.|:|.:.|.|.|:..:..::.|..|  .::|.
pombe    46 PFTKQKPKSPPFFSLNAKVPVLLALLLGFQHALAMVGGVTSPPRIIAASANLTTEQTN--YLVSA 108

  Fly    90 MIFVTGIVTYFQATWGVRLPIVQG--GT-------ISFLVPTLAILALPQW----KCPEQAVMDA 141
            .:..:||:|..|.. .|.:|..:.  ||       |||...::|...|.|.    .||:.
pombe   109 GLISSGIMTLIQIA-RVHIPKTKYYIGTGMLSVLGISFTSVSVAPKVLSQMYENGYCPKD----- 167

  Fly   142 MDEAEREELWQVRMRELSGAI----AVSAMVQVILGYTGLVGKILKYV-TPLTIVPTVSLVGLTL 201
                  |...::...:..||.    .|.:::::.:.:  :..:|||.: .|:...|.|.|:|.:|
pombe   168 ------ENGTKLPCPDGYGAFLATACVCSLLEIFMSF--IPPRILKRLFPPIVTGPVVLLIGTSL 224

  Fly   202 FEHAAETASKHWGIAVGT-TGMLTL-----FSQIMSNVPVPILAYRKGHGLEIRQFQLFRL-FPV 259
            .    .:....|....|: ||..|.     :|...|:.        ..|.|.....|...| |.|
pombe   225 I----SSGLNDWAGGEGSCTGRPTEAEAPGYSLCPSDT--------SPHALGWGSAQFIGLGFSV 277

  Fly   260 LLTIMIMWGLCGILTATDVFPPSHPSRTDVRL----NVLTSAKWFYVPYPGQFGWPSVTLS---- 316
            ..||:|:          :.|.|.....|.|.|    .::.||...|..:......|.||.:
pombe   278 FATIIII----------ERFGPPLMKTTSVVLGLVVGMIISAATGYWDHSIIDAAPVVTFNWVHT 332

  Fly   317 --------GVLGMLAGVLACTVESLSYYPTVSQMS--GAHSPPLHA-INRGIGTEGFGTVLAGLW 370
                    .||.|||..:...:|::......|.:|  ....|...| :..||..:|..:::|.|.
pombe   333 FRLRIYGPAVLPMLALYIVNMMEAIGDIGATSDVSMLEVDGPAFDARVQGGILGDGLASLIASLM 397

  Fly   371 GAGNGTNTFGENVGAIGVTKIGSRRVIQWAALIMVLQGVIGKFGAIFILIPDSVVGGIFCVMFGM 435
             ......||.:|.|.|.:||..:||...:.|:|:...|:..||.|:|:.||..|:||:...:|..
pombe   398 -TTTPLTTFAQNNGVISLTKCANRRAGFFCAVILFFMGLFAKFAAVFVAIPSPVLGGMTTFLFSS 461

  Fly   436 IIAFGLSTLQYVDLRSARNLYILGLSIFFPMVLCRWMQKNPGAI------------DTGNKTVD- 487
            :...|::.:..:.. :.||.:||..|:...|          |||            ...||.:.
pombe   462 VAVSGIAIISQIPF-NRRNRFILTASMTLGM----------GAILVPDWFTYFFEYSGPNKALVG 515

  Fly   488 --STLSVLLGTTILVGGVLGCLLDNIIPGTPEERGLIDWANEMP-LGDDN-VNDG 538
              ..:::::.....:|..:...|:.|:|...:.    |..|:.| |...| ||:|
pombe   516 FLDAITLVMENGFAIGAFISIFLNLILPYEFDP----DLTNDSPGLSTTNGVNNG 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6293	NP_001262459.1	HCO3_cotransp	32..519	CDD:304903	126/545 (23%)
CG6293	NP_001262459.1	Xan_ur_permease	48..464	CDD:279232	112/459 (24%)
SPAC1399.01c	NP_593513.1	UraA	53..549	CDD:225142	126/549 (23%)
SPAC1399.01c	NP_593513.1	Xan_ur_permease	69..498	CDD:279232	116/478 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	70	1.000	Domainoid score	I2663
eggNOG	1	0.900	-	-		E1_COG2233
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	83	1.000	Inparanoid score	I1816
OMA	1	1.010	-	-		QHG61611
OrthoFinder	1	1.000	-	-		FOG0000230
OrthoInspector	1	1.000	-	-		oto101265
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1881
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.900