DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6293 and Slc23a3

DIOPT Version :9

Sequence 1:	NP_001262459.1	Gene:	CG6293 / 41259	FlyBaseID:	FBgn0037807	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_919314.2	Gene:	Slc23a3 / 22626	MGIID:	104516	Length:	611	Species:	Mus musculus

Alignment Length:	528	Identity:	163/528 - (30%)
Similarity:	265/528 - (50%)	Gaps:	38/528 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SKSYSQAANTPPSNEKPKPQLLYAINDNP-------------PWYLSIFLAFQHYLTMIGAIVSI 66
            |:.|.   :||    .|.|.||..: .||             .|.||..||.||:|.:...:.:.
Mouse    13 SEGYQ---DTP----APLPPLLPPL-QNPSSRSWASRVCGPSTWGLSCLLALQHFLVLASLLWAS 69

  Fly    67 PFILTPALCMSDEDANRGIIISTMIFVTGIVTYFQATWGVRLPIVQGGTISFLVPTLAIL--ALP 129
            ..:|...|...........::::..|..|:.|..|...|.|||::|..::.||:|.|.:.  .||
Mouse    70 HLLLLHGLPPGGLSYPPAQLLASSFFSCGLSTVLQTWMGSRLPLIQAPSLEFLIPALVLTNQKLP 134

  Fly   130 -QWKCPEQAVMD-AMDEAERE----ELWQVRMRELSGAIAVSAMVQVILGYTGLVGKILKYVTPL 188
             ..|.|..|.:. .:....|.    |||...:||:|||:.||.::|..:|..|:.|::..|..||
Mouse   135 LTTKTPGNASLSLPLCSLTRSCHGLELWNTSLREVSGAVVVSGLLQGTIGLLGVPGRVFPYCGPL 199

  Fly   189 TIVPTVSLVGLTLFEHAAETASKHWGIAVGTTGMLTLFSQIMSNVPVPILAYRKGHGLEIRQFQL 253
            .:.|::.:.||:..:..|:..|.|||:|:....::.:.||.:.:..:|:.::|...........:
Mouse   200 VLAPSLVVAGLSAHKEVAQFCSAHWGLALLLILLMVVCSQHLGSCQIPLCSWRPSSTSTHICIPV 264

  Fly   254 FRLFPVLLTIMIMWGLCGILTATDVFPPSHPSRTDVRLNVLTSAKWFYVPYPGQFGWPSVTLSGV 318
            |||..||..:..:|.:...: .|.|.|        ::|:..:.|.||::|:||::.||.:|...:
Mouse   265 FRLLSVLAPVACVWFISAFV-GTSVIP--------LQLSEPSDAPWFWLPHPGEWEWPLLTPRAL 320

  Fly   319 LGMLAGVLACTVESLSYYPTVSQMSGAHSPPLHAINRGIGTEGFGTVLAGLWGAGNGTNTFGENV 383
            ...::..||.:..||..|....|:.....||.||.:||:..||.|:|||||.|:..||.:...||
Mouse   321 AAGISMALAASTSSLGCYALCGQLLRLSPPPPHACSRGLSLEGLGSVLAGLLGSPLGTASSFPNV 385

  Fly   384 GAIGVTKIGSRRVIQWAALIMVLQGVIGKFGAIFILIPDSVVGGIFCVMFGMIIAFGLSTLQYVD 448
            |.:.:.:.|||||.....|..:..|:..:...:|..||..|:||:..|...::::.|.|:....|
Mouse   386 GTVSLFQTGSRRVAHLVGLFCMGLGLSPRLAQLFTSIPLPVLGGVLGVTQAVVLSAGFSSFHLAD 450

  Fly   449 LRSARNLYILGLSIFFPMVLCRWMQKNPGAIDTGNKTVDSTLSVLLGTTILVGGVLGCLLDNIIP 513
            :.|.||::|:|.|||..::|.||:::.|..::||...:|..|..||...|.:.|:||.||:|.|.
Mouse   451 IDSGRNVFIVGFSIFMALLLPRWLREAPVLLNTGWSPLDMFLRSLLAEPIFLAGLLGFLLENTIS 515

  Fly   514 GTPEERGL 521
            ||..||||
Mouse   516 GTRAERGL 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6293	NP_001262459.1	HCO3_cotransp	32..519	CDD:304903	154/507 (30%)
CG6293	NP_001262459.1	Xan_ur_permease	48..464	CDD:279232	126/423 (30%)
Slc23a3	NP_919314.2	Xan_ur_permease	83..476	CDD:279232	122/401 (30%)
		HCO3_cotransp	87..482	CDD:304903	123/403 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..611
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842428
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2233
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000230
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11119
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840