DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6293 and Slc23a1

DIOPT Version :9

Sequence 1:	NP_001262459.1	Gene:	CG6293 / 41259	FlyBaseID:	FBgn0037807	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	XP_017173340.2	Gene:	Slc23a1 / 20522	MGIID:	1341903	Length:	668	Species:	Mus musculus

Alignment Length:	571	Identity:	252/571 - (44%)
Similarity:	360/571 - (63%)	Gaps:	19/571 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IEDATDASKSYSQAANTPPSNEKPKPQLLYAINDNPPWYLSIFLAFQHYLTMIGAIVSIPFILTP 72
            :.|:...|....||    |...:||..:||.|.|.|||||.|.|.||||||.....:::||:|..
Mouse    78 VVDSAGTSTRDRQA----PLPTEPKFDMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAE 138

  Fly    73 ALCMSDEDANRGIIISTMIFVTGIVTYFQATWGVRLPIVQGGTISFLVPTLAILALPQWKCP--E 135
            |||:..:......:|.|:....||.|..|.|.|:|||:.|....:||||..:||||.:||||  |
Mouse   139 ALCVGRDQHMVSQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKSILALERWKCPSEE 203

  Fly   136 QAVMDAMDEAEREELWQVRMRELSGAIAVSAMVQVILGYTGLVGKILKYVTPLTIVPTVSLVGLT 200
            :...:.........:|..|:||:.|||.||:||:|::|..||.|.:|.|:.|||:.|||||:||:
Mouse   204 EIYGNWSMPLNTSHIWHPRIREVQGAIMVSSMVEVVIGLMGLPGALLSYIGPLTVTPTVSLIGLS 268

  Fly   201 LFEHAAETASKHWGIAVGTTGMLTLFSQIMSNVPVPILAYRKGHGLEIRQFQLFRLFPVLLTIMI 265
            :|:.|.:.|..||||:..:..::.||||.:.|:...:..||.|.||.:.:.|:|::||::|.||.
Mouse   269 VFQAAGDRAGSHWGISACSILLIVLFSQYLRNLTFLLPVYRWGKGLTLFRVQIFKMFPIVLAIMT 333

  Fly   266 MWGLCGILTATDVFPP-----SHPSRTDVRLNVLTSAKWFYVPYPGQFGWPSVTLSGVLGMLAGV 325
            :|.||.:||.|||.|.     ...:|||.|.:::..:.|..:|||.|:|.|:||::.||||.:..
Mouse   334 VWLLCYVLTLTDVLPADPTVYGFQARTDARGDIMAISPWIRIPYPCQWGLPTVTVAAVLGMFSAT 398

  Fly   326 LACTVESLSYYPTVSQMSGAHSPPLHAINRGIGTEGFGTVLAGLWGAGNGTNTFGENVGAIGVTK 390
            ||..:||:..|...::::||..||:|||||||.|||...::|||.|.|||:.:...|:|.:|:||
Mouse   399 LAGIIESIGDYYACARLAGAPPPPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPNIGVLGITK 463

  Fly   391 IGSRRVIQWAALIMVLQGVIGKFGAIFILIPDSVVGGIFCVMFGMIIAFGLSTLQYVDLRSARNL 455
            :|||||:|:.|.||::.|.||||.|:|..:||.::||:||.:||||.|.|||.||:||:.|:|||
Mouse   464 VGSRRVVQYGAGIMLILGAIGKFTALFASLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNL 528

  Fly   456 YILGLSIFFPMVLCRWMQKNPGAIDTGNKTVDSTLSVLLGTTILVGGVLGCLLDNIIPGTPEERG 520
            ::||.|:||.:.|..::..|||||:||...||..|:|||.|.:.|||.|..:|||.:||:|||||
Mouse   529 FVLGFSMFFGLTLPNYLDSNPGAINTGIPEVDQILTVLLTTEMFVGGCLAFILDNTVPGSPEERG 593

  Fly   521 LIDWANEMPLGDDNVNDGTAT---DYDFPLGMDAIRRWKWTYYIPFMPTYK 568
            ||.|.     ...:.|..|:.   .||||.||..::|..:..|||..|.::
Mouse   594 LIQWK-----AGAHANSETSASLKSYDFPFGMGMVKRTTFFRYIPICPVFR 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6293	NP_001262459.1	HCO3_cotransp	32..519	CDD:304903	227/493 (46%)
CG6293	NP_001262459.1	Xan_ur_permease	48..464	CDD:279232	189/422 (45%)
Slc23a1	XP_017173340.2	Xan_ur_permease	115..542	CDD:366341	191/426 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	422	1.000	Domainoid score	I629
eggNOG	1	0.900	-	-		E1_COG2233
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1329
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61611
OrthoDB	1	1.010	-	-		D219070at33208
OrthoFinder	1	1.000	-	-		FOG0000230
OrthoInspector	1	1.000	-	-		otm43403
orthoMCL	1	0.900	-	-		OOG6_100583
Panther	1	1.100	-	-	O	PTHR11119
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1881
SonicParanoid	1	1.000	-	-		X261
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.870