DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6293 and T07G12.2

DIOPT Version :9

Sequence 1:	NP_001262459.1	Gene:	CG6293 / 41259	FlyBaseID:	FBgn0037807	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_501944.2	Gene:	T07G12.2 / 188241	WormBaseID:	WBGene00011593	Length:	544	Species:	Caenorhabditis elegans

Alignment Length:	503	Identity:	168/503 - (33%)
Similarity:	265/503 - (52%)	Gaps:	27/503 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 KPKPQLLYAINDNPPWYLSIFLAFQHYLTMIGAIVSIPFILTPALCMSDEDAN-RGIIISTMIFV 93
            |....|.:.:||.|......|...|..|..|.|::..|:.::..||...|... |..:|:.....
Worm     3 KNSGDLHFHVNDVPHKSAIFFFGLQQMLVCISALLVTPYFVSNLLCAGAETTEVRVQLIAATFIS 67

  Fly    94 TGIVTYFQATWGVRLPIVQGGTISFLVPTLAILALPQWKCPEQAVMDAMDEAEREELWQVRMREL 158
            :||.|..|.|:|:||.|:.|.:.:|. |.|.... ..:.|....     |..:    |:.:::.:
Worm    68 SGIATILQTTFGLRLAILHGPSFAFF-PALHTFG-DVYPCNSDT-----DTTQ----WKEKLQMI 121

  Fly   159 SGAIAVSAMVQVILGYTGLVGKILKYVTPLTIVPTVSLVGLTLFEHAAETASKHWGIAVGTTGML 223
            ||::.|:.::...||.||:||:|.|::.|:||||.:.|:.:...:...:..|.|| |::....:|
Worm   122 SGSLFVAVLIMPFLGITGMVGRIAKHIGPITIVPMLMLLCIGTVQDIEQKVSHHW-ISIVEILLL 185

  Fly   224 TLFSQIMSNVPVPILAYRKGHGLEIRQF-----QLFRLFPVLLTIMIMWGLCGILTATDVFPPSH 283
            .:|..::....||:.|:    .:|.:.|     ::|..||.||.|||.|.:|.|||.||:.|...
Worm   186 IIFVVLLEEFEVPMPAF----SMEKKAFYTAKMKIFSQFPYLLGIMIAWFVCWILTITDLEPYGC 246

  Fly   284 PSRTD--VRLNVLTSAKWFYVPYPGQFGWPSVTLSGVLGMLAGVLACTVESLSYYPTVSQMSGAH 346
            .:|||  ..|.||.:..|..:.||.|:|.|.::...::...|.:||.|:||:..|...:::....
Worm   247 SARTDRNESLFVLENTPWIQIQYPLQYGLPKLSAPLIIAFSASMLAATIESIGNYGICARICQQG 311

  Fly   347 SPPLHAINRGIGTEGFGTVLAGLWGAGNGTNTFGENVGAIGVTKIGSRRVIQWAALIMVLQGVIG 411
            |||..::||....||||::||.|.|.|.|..|:.||:..:.|||:.||..:|.|.:|::|.|:..
Worm   312 SPPSSSMNRAFVVEGFGSMLAALMGVGTGVTTYSENIAIMQVTKVTSRITMQCAGVILILMGIFS 376

  Fly   412 KFGAIFILIPDSVVGGIFCVMFGMIIAFGLSTLQYVDLRSARNLYILGLSIFFPMVLCRWMQKNP 476
            ||.|...:||::::||:......||.....|.||.||||.:|||.|:||||.....:....:|:|
Worm   377 KFAAFLAMIPEAIIGGVLTAGMSMICGVAFSNLQSVDLRLSRNLTIIGLSIILGCTIPAHFEKSP 441

  Fly   477 GAIDTGNKTVDSTLSVLLGTTILVGGVLGCLLDNIIPG-TPEERGLID 523
              :.:||||:|.....||...:||||::...||.|..| |.::||..|
Worm   442 --LHSGNKTIDDIFGTLLKMRMLVGGLIAFCLDIIASGATRKQRGFED 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6293	NP_001262459.1	HCO3_cotransp	32..519	CDD:304903	164/495 (33%)
CG6293	NP_001262459.1	Xan_ur_permease	48..464	CDD:279232	142/423 (34%)
T07G12.2	NP_501944.2	HCO3_cotransp	12..430	CDD:304903	145/433 (33%)
T07G12.2	NP_501944.2	Xan_ur_permease	21..439	CDD:279232	142/433 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	242	1.000	Domainoid score	I1235
eggNOG	1	0.900	-	-		E1_COG2233
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H112955
Inparanoid	1	1.050	287	1.000	Inparanoid score	I1711
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61611
OrthoDB	1	1.010	-	-		D219070at33208
OrthoFinder	1	1.000	-	-		FOG0000230
OrthoInspector	1	1.000	-	-		otm14321
orthoMCL	1	0.900	-	-		OOG6_100583
Panther	1	1.100	-	-	O	PTHR11119
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X261
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880