DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6293 and R11E3.2

DIOPT Version :9

Sequence 1:	NP_001262459.1	Gene:	CG6293 / 41259	FlyBaseID:	FBgn0037807	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_500641.1	Gene:	R11E3.2 / 187811	WormBaseID:	WBGene00020004	Length:	546	Species:	Caenorhabditis elegans

Alignment Length:	551	Identity:	172/551 - (31%)
Similarity:	298/551 - (54%)	Gaps:	38/551 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EKPKPQLLYAINDNPPWYLSIFLAFQHYLTMIGAIVSIPFILTPALCMSDEDANRGIIISTMIFV 93
            |:.:.:|::.:||.|.....:.:.||..:..|..::.||::::..:|..|::....:.:.:..||
Worm     3 EEKEDELVHHVNDIPSIPTILLIGFQQMMICISMLLVIPYMMSDMVCPGDKETEIRVQLISASFV 67

  Fly    94 T-GIVTYFQATWGVRLPIVQGGTISFLVPTLAILALPQWKCPEQAVMDAMDEAEREELWQVRMRE 157
            | ||.|..|.|:|:||.|:.|.:.::| |.|.... ..:.|         :|.....|||.:|:.
Worm    68 TAGIATILQTTFGMRLAILHGPSFAYL-PVLNTFQ-STYPC---------NEHTDTSLWQHKMQM 121

  Fly   158 LSGAIAVSAMVQVILGYTGLVGKILKYVTPLTIVPTVSLVGLTLFEHAAETASKHWGIAVGTTGM 222
            :||:..|:.:|..:.|:|||:|.:.:::.|:||||.::|:.::......:..:.||..:|... |
Worm   122 ISGSCLVAVLVMPLFGFTGLIGFLSQFIGPITIVPIMTLLTISAVSDVEQKMALHWMSSVEFL-M 185

  Fly   223 LTLFSQIMSNVPVPILAYRKGHGLEIRQFQLFR-----LFPVLLTIMIMWGLCGILTATDVFPPS 282
            |.:|..::.:..:|:.||    .|:.|.|.:.|     .||.::.|.|.|.:|.|||.|:..|.:
Worm   186 LVVFIVLLEHWEMPLPAY----SLKRRHFYIARRKILSQFPYIIGIAIGWLICYILTVTNAIPAN 246

  Fly   283 HPSRTDVR--LNVLTSAKWFYVPYPGQFGWPSVTLSGVLGMLAGVLACTVESLSYYPTVSQMSGA 345
            .|:|||..  :.:|.|..|.:||.|||:|.|.:.:|.:.|.:|......:||:..|...:::|..
Worm   247 SPARTDQNSTMEILKSTPWVHVPIPGQYGTPIIDISLLCGFIASSFVAMIESIGDYNLCAKLSKQ 311

  Fly   346 HSPPLHAINRGIGTEGFGTVLAGLWGAGNGTNTFGENVGAIGVTKIGSRRVIQWAALIMVLQGVI 410
            ...|...:|||...||.|.:|:..:|.|.|..|:.||:..:.|||:.||..:|.|.:.:::.|:.
Worm   312 GRIPTSNLNRGFIVEGIGCMLSSSFGIGTGITTYAENIAIMSVTKVASRITMQTAGIFLLIAGIF 376

  Fly   411 GKFGAIFILIPDSVVGGIFCVMFGMIIAFGLSTLQYVDLRSARNLYILGLSIFFPMVLCRWMQKN 475
            .||.|:..:||:.||||:..:...|:....|..|..||||.:|||.|:|:::...:.:....:.|
Worm   377 SKFAAVLAMIPEPVVGGVLAIGICMVNGVVLRNLMTVDLRLSRNLTIMGIAVIMGLTVALHFENN 441

  Fly   476 PGAIDTGNKTVDSTLSVLLGTTILVGGVLGCLLDNIIPG-TPEERGLIDWANEMPLGDDNV---N 536
            |  :.|||:|||:....||...:|:||::...||||.|| |.|:||.....::   |:|::   |
Worm   442 P--LKTGNQTVDNVFGTLLTIRMLIGGIIAFTLDNIAPGATREQRGFRKADDD---GEDDIPVEN 501

  Fly   537 DGTATDYDFPLGMDA-IRRWKWTYYIPFMPT 566
            :|.|    .|..|:. ..:::|..|||.:|:
Worm   502 NGFA----LPSFMNRFFLKYRWLTYIPLIPS 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6293	NP_001262459.1	HCO3_cotransp	32..519	CDD:304903	157/495 (32%)
CG6293	NP_001262459.1	Xan_ur_permease	48..464	CDD:279232	132/423 (31%)
R11E3.2	NP_500641.1	Xan_ur_permease	22..439	CDD:279232	132/432 (31%)
R11E3.2	NP_500641.1	HCO3_cotransp	61..437	CDD:304903	125/391 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	242	1.000	Domainoid score	I1235
eggNOG	1	0.900	-	-		E1_COG2233
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H112955
Inparanoid	1	1.050	287	1.000	Inparanoid score	I1711
Isobase	1	0.950	-	0	Normalized mean entropy	S4185
OMA	1	1.010	-	-		QHG61611
OrthoDB	1	1.010	-	-		D219070at33208
OrthoFinder	1	1.000	-	-		FOG0000230
OrthoInspector	1	1.000	-	-		otm14321
orthoMCL	1	0.900	-	-		OOG6_100583
Panther	1	1.100	-	-	O	PTHR11119
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1881
SonicParanoid	1	1.000	-	-		X261
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.860