DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6293 and C51E3.6

DIOPT Version :9

Sequence 1:	NP_001262459.1	Gene:	CG6293 / 41259	FlyBaseID:	FBgn0037807	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_505613.1	Gene:	C51E3.6 / 183708	WormBaseID:	WBGene00008252	Length:	555	Species:	Caenorhabditis elegans

Alignment Length:	573	Identity:	176/573 - (30%)
Similarity:	287/573 - (50%)	Gaps:	48/573 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VTIEDATDASKSYSQAANTPPSNEKPKPQLLYAINDNPPWYLSIFLAFQHYLTMIGAIVSIPFIL 70
            |.|.:...|.:.:.:|.:|||..                  :::....|..:..:.|::::|.|:
Worm     8 VEIREKKTAQRPFLKARDTPPIG------------------IALLYGLQQVMVCVSALLTVPLIM 54

  Fly    71 TPALCMSDEDA-NRGIIISTMIFVTGIVTYFQATWGVRLPIVQGGTISFLVPTLAILALPQWKCP 134
            ..::|.....| .|..:||:....:||.|..|..:|:||.::||...:::......::||:..|
Worm    55 ADSMCPGSSIAVLRQTLISSTFVSSGISTIIQTLFGMRLALLQGTAFAYVPSVQGFMSLPENTC- 118

  Fly   135 EQAVMDAMD-EAEREELWQVRMRELSGAIAVSAMVQVILGYTGLVGKILKYVTPLTIVPTVSLVG 198
                 :|.: :...||::..::..|.|.:..|:.|.:::|.|||||.:.|::.|||:.|.:.|:.
Worm   119 -----NATESDYVPEEVYYGKLALLQGCLIASSFVPILIGATGLVGMLTKFIGPLTVSPLMLLLA 178

  Fly   199 LTLFEHAAETASKHWGIAVGTTGMLTLFSQIM----SNVPVPILAYRKGHGLEIRQFQLFRLFPV 259
            .:..:......||||   |.....:|||:.|:    ..||||.:...|.|...|   .||..:|.
Worm   179 FSQVDLMVTHISKHW---VAIVQAVTLFATILYLAEVKVPVPGIKNGKFHWYRI---NLFGQYPY 237

  Fly   260 LLTIMIMWGLCGILTATDVFPPSHPSRTD--VRLNVLTSAKWFYVPYPGQFGWPSVTLSGVLGML 322
            |:.|...|..|..||..::.|....:|.|  :.|.|:..:.|..|||||:||.|.......|..|
Worm   238 LIAICTSWIFCVALTIFNLTPEGSAARVDKNISLAVIRESSWLEVPYPGKFGPPQFNTGLFLLFL 302

  Fly   323 AGVLACTVESLSYYPTVSQMSGAHSPPLHAINRGIGTEGFGTVLAGLWGAGNGTNTFGENVGAIG 387
            ...:....||:..|...:::|....||.|||||||..||.|::::||.|.|.|..|..||:|.||
Worm   303 LSAMTSVFESVGDYHAAARVSEERPPPSHAINRGILAEGLGSLISGLLGPGVGMTTHTENIGVIG 367

  Fly   388 VTKIGSRRVIQWAALIMVLQGVIGKFGAIFILIPDSVVGGIFCVMFGMIIAFGLSTLQYVDLRSA 452
            ||::.||..:..|.:.:::.|:|.|.||:...|||.:|||:......|::...:|.||.||:..:
Worm   368 VTRVASRWTMVMAGVFLIILGLITKIGALLSTIPDPLVGGVLASSMAMVVGVAVSNLQTVDMTLS 432

  Fly   453 RNLYILGLSIFFPMVLCRWMQKNPGAIDTGNKTVDSTLSVLLGTTILVGGVLGCLLDNIIPG-TP 516
            ||:.|.|.|:.|.:::.::.:..|  :||.....:..|:|||...:.||.:..|:|||.|.| |.
Worm   433 RNMGIFGFSMMFGLIVPKYFKLFP--VDTDWGWFNQILNVLLQMPMFVGALCACILDNSIGGATR 495

  Fly   517 EERGLIDWANEMPLGDDNVNDGTATDYDFPLG-MDAIRRWKWTYYIPFMPTYK 568
            |:||| ....|:..|  .:::.|   |.:|.. |:.:.|.....|||.||..|
Worm   496 EQRGL-RARGEIYAG--GIDECT---YSYPKWVMNILNRIPGVQYIPCMPKEK 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6293	NP_001262459.1	HCO3_cotransp	32..519	CDD:304903	153/495 (31%)
CG6293	NP_001262459.1	Xan_ur_permease	48..464	CDD:279232	135/423 (32%)
C51E3.6	NP_505613.1	HCO3_cotransp	17..497	CDD:304903	156/511 (31%)
C51E3.6	NP_505613.1	Xan_ur_permease	30..454	CDD:279232	136/453 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	242	1.000	Domainoid score	I1235
eggNOG	1	0.900	-	-		E1_COG2233
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H112955
Inparanoid	1	1.050	287	1.000	Inparanoid score	I1711
Isobase	1	0.950	-	0	Normalized mean entropy	S4185
OMA	1	1.010	-	-		QHG61611
OrthoDB	1	1.010	-	-		D219070at33208
OrthoFinder	1	1.000	-	-		FOG0000230
OrthoInspector	1	1.000	-	-		otm14321
orthoMCL	1	0.900	-	-		OOG6_100583
Panther	1	1.100	-	-	O	PTHR11119
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1881
SonicParanoid	1	1.000	-	-		X261
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.860