DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6293 and Y59E9AL.4

DIOPT Version :9

Sequence 1:	NP_001262459.1	Gene:	CG6293 / 41259	FlyBaseID:	FBgn0037807	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_500742.3	Gene:	Y59E9AL.4 / 177296	WormBaseID:	WBGene00021994	Length:	555	Species:	Caenorhabditis elegans

Alignment Length:	555	Identity:	174/555 - (31%)
Similarity:	288/555 - (51%)	Gaps:	38/555 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 INDNPPWYLSIFLAFQHYLTMIGAIVSIPFILTPALCMSDEDANRGIIISTMIFVT-GIVTYFQA 102
            :||.|.....:...||..:..:..::..||:::...|.........:.:.:..||: ||.|.||.
Worm     9 VNDVPSIKGILGFGFQQAMLCMSGLLVYPFLISNCACAGAAAVQLRVQLISATFVSCGIATIFQT 73

  Fly   103 TWGVRLPIVQGGTISFLVPTLAILALPQWKCPEQAVMDAMDEAEREELWQVRMRELSGAIAVSAM 167
            |:|:||.::.|..::||.|..|...  |..||    ....||.. .|.|..||||:.|::.::..
Worm    74 TFGLRLSVLHGPAMAFLPPLFAYKT--QNLCP----YTEHDEVP-PEFWMERMREIQGSLLLACF 131

  Fly   168 VQVILGYTGLVGKILKYVTPLTIVPTVSLVGLTLFEHAAETASKHWGIAVGTTGMLTLFSQIMSN 232
            |.:::|.||:.|.:.|.:.|:||||.:.|:..::.....|..|.|| |::....::.:.:..:.|
Worm   132 VFILVGMTGIAGHLSKLIGPITIVPLMLLLTTSIVPTIEEKLSLHW-ISMVMLLVVVMMAVYLEN 195

  Fly   233 VPVPILAYRKGHGLEIRQF-----QLFRLFPVLLTIMIMWGLCGILTATDVFPPSHPSRTD--VR 290
            ..||...|    ..|.:|.     :||..||.||:::.:|.:|.|:|.||:.|.:..:|||  |.
Worm   196 TRVPFYYY----NTEKKQIVSTKVRLFGQFPYLLSMLFVWFICFIMTITDLEPYNGAARTDNNVT 256

  Fly   291 LNVLTSAKWFYVPYPGQFGWPSVTLSGVLGMLAGVLACTVESLSYYPTVSQMSGAHSPPLHAINR 355
            :.||..:.||.||.|..||.|.::.....|.:|.|||..:|::..|..:::.|....||..||||
Worm   257 MMVLRESPWFQVPLPFPFGIPKISAGIFFGYIASVLASIIENIGSYDLLARTSQQKPPPKDAINR 321

  Fly   356 GIGTEGFGTVLAGLWGAGNGTNTFGENVGAIGVTKIGSRRVIQWAALIMVLQGVIGKFGAIFILI 420
            .|..||.|:::|.:.|..:|..|:.||:..|.:||:.||..:|:|..|:::.|:..||.||...|
Worm   322 AIAMEGVGSLIAAVTGVSSGVTTYAENIALIHITKVASRATMQFAGFILIMLGLFSKFAAILASI 386

  Fly   421 PDSVVGGIFCVMFGMIIAFGLSTLQYVDLRSARNLYILGLSIFFPMVLCRWMQKNPGAIDTGNKT 485
            ||::|||:..:...||....:|.||.:||...|||.|:|||:...:::....:|:|  ::||:..
Worm   387 PDALVGGLLTMGISMIGGVAMSNLQMIDLNLCRNLSIMGLSLLLGLIVPLHFEKHP--VNTGHFE 449

  Fly   486 VDSTLSVLLGTTILVGGVLGCLLDNIIPG-TPEERGLIDW---ANEMPLGDDNVNDGTATDYDFP 546
            :|..|::||...:|||||:...|||.:|| |..:||..:.   .:|..:...|.::.:...::..
Worm   450 IDHILNMLLNIKMLVGGVVATFLDNTVPGATRAQRGFREHHRVPSESDVSTSNSSETSGASFEVL 514

  Fly   547 LGMDA----------IRRWKWTYYIPFMPTYKLQK 571
            ...||          :|.:.....:|.:|  ||.|
Worm   515 PSSDAYTFPEVFQRLLRAFPVLQLLPILP--KLSK 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6293	NP_001262459.1	HCO3_cotransp	32..519	CDD:304903	162/488 (33%)
CG6293	NP_001262459.1	Xan_ur_permease	48..464	CDD:279232	140/423 (33%)
Y59E9AL.4	NP_500742.3	HCO3_cotransp	1..483	CDD:304903	162/487 (33%)
Y59E9AL.4	NP_500742.3	Xan_ur_permease	21..440	CDD:279232	140/430 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	242	1.000	Domainoid score	I1235
eggNOG	1	0.900	-	-		E1_COG2233
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H112955
Inparanoid	1	1.050	287	1.000	Inparanoid score	I1711
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61611
OrthoDB	1	1.010	-	-		D219070at33208
OrthoFinder	1	1.000	-	-		FOG0000230
OrthoInspector	1	1.000	-	-		otm14321
orthoMCL	1	0.900	-	-		OOG6_100583
Panther	1	1.100	-	-	LDO	PTHR11119
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1881
SonicParanoid	1	1.000	-	-		X261
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.910