DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nuak1 and NUAK1

DIOPT Version :9

Sequence 1:	NP_001369005.1	Gene:	Nuak1 / 41256	FlyBaseID:	FBgn0262617	Length:	2803	Species:	Drosophila melanogaster
Sequence 2:	NP_055655.1	Gene:	NUAK1 / 9891	HGNCID:	14311	Length:	661	Species:	Homo sapiens

Alignment Length:	652	Identity:	234/652 - (35%)
Similarity:	348/652 - (53%)	Gaps:	95/652 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 AAAPTGLDATGNSLAHPSGIPQDQIDNIMSGI--ANTGNVKMNNHRKKLRQRFDIIKKLGQGTYG 82
            ||||...|.....|..| |.|::.:....:.:  .....||.::|:..|:.|:::.:.||:||||
Human     4 AAAPVAGDRPDLGLGAP-GSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQETLGKGTYG 67

  Fly    83 KVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFENREKMVLVM 147
            ||:....:.:|:.||||:|:|.||:.|.|:|.||||::||||::||:||.|||||||::|:|::|
Human    68 KVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIM 132

  Fly   148 EFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDEKGNAKIADF 212
            |:|:.||||||:|||:.|:|.|.|..|||:.:||:||||:.:.||||||||||||:..|.|||||
Human   133 EYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADF 197

  Fly   213 GLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPFDGSNFKRLV 277
            ||||::...:.|.||||||||||||||.|.||:|||||.|:|||||||||||:|||||.:.|.|:
Human   198 GLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLI 262

  Fly   278 KQISQGDYYEPRKPSRASTLIRDMLTVCPRKRASIEQICSHWWVNENDNVSCLDLAEDLANQTPV 342
            :|||.|:|.||.:||.|..|||.||.|.|.:||:||.|.:|||||.....|..|......:::|:
Human   263 RQISSGEYREPTQPSDARGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALHDSESPL 327

  Fly   343 RLDVLLSLTPAT-ITADQLVVPSAEGAAAAKAAANE-RVPRSHSVGSIRDMGPPNTEAERRILDM 405
            ...::.....:| :.||    ..|:....||...:| .:.|..|:           :..::..|.
Human   328 LARIIDWHHRSTGLQAD----TEAKMKGLAKPTTSEVMLERQRSL-----------KKSKKENDF 377

  Fly   406 VAAGGEAALMPSPTRTITPAQSPVQTKR-----KLQPTVSTENAAGTTAKKKEKPA-NSSFVISK 464
             |..|:.|:..||::..:.....:..||     :...|...|...|        || .|:|.:.:
Human   378 -AQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGVVG--------PALPSTFKMEQ 433

  Fly   465 D---------GAPLTEAPPTIIEPQATLMEAETIANIPEEVPVPSYSQKDMQAVGDICDL--LMG 518
            |         .:|..|.|..:...|:..|..:.|....::.....||..:.....::.|.  :||
Human   434 DLCRTGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVMG 498

  Fly   519 TATTPAPAPPAPTPV---------------ARQPTRGKLDAVVETPEEKDATKVIKKFVNKHKTA 568
             ::.|:|:||.|..|               :.:.:.|.:|..:.:||....
Human   499 -SSIPSPSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPALVSPEMPTL-------------- 548

  Fly   569 DLVNAINESASKAAAPVSAVAPPPFVRKCS-LQDESTLNKFNAE----------RRKSRILETAE 622
                   ||.|:...|...:: ..:.|..| :.|:|.|:..:.:          |::.|...:||
Human   549 -------ESLSEPGVPAEGLS-RSYSRPSSVISDDSVLSSDSFDLLDLQENRPARQRIRSCVSAE 605

  Fly   623 KF 624
            .|
Human   606 NF 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	155/252 (62%)
NUAK1	NP_055655.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		8/20 (40%)
		STKc_NUAK	53..306	CDD:270975	155/252 (62%)
		S_TKc	55..306	CDD:214567	154/250 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	345..421		16/87 (18%)
		GILK motif	399..402		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..570		26/150 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155248
Domainoid	1	1.000	331	1.000	Domainoid score	I1148
eggNOG	1	0.900	-	-		E1_KOG0611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2340
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002307
OrthoInspector	1	1.000	-	-		otm41539
orthoMCL	1	0.900	-	-		OOG6_106932
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5135
SonicParanoid	1	1.000	-	-		X2001
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.620