DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nuak1 and KIN4

DIOPT Version :9

Sequence 1:	NP_001369005.1	Gene:	Nuak1 / 41256	FlyBaseID:	FBgn0262617	Length:	2803	Species:	Drosophila melanogaster
Sequence 2:	NP_014876.1	Gene:	KIN4 / 854408	SGDID:	S000005759	Length:	800	Species:	Saccharomyces cerevisiae

Alignment Length:	833	Identity:	206/833 - (24%)
Similarity:	340/833 - (40%)	Gaps:	193/833 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GNVKMNNHRKKLRQRFDII-------------------KKLGQGTYGKVQLGINK-----ETGQE 95
            |||..:..|..|::..:|:                   ..||:|.:|||:||..|     |..::
Yeast    12 GNVVTDRDRHSLQRNNEILHPIHKNQRKHATFGPYIIGSTLGEGEFGKVKLGWTKASSSNEVPKQ 76

  Fly    96 VAIKTIKKCKIEAEADL-VRIRREVQIMSSVHHPNIIHIYEVFENREKMVLVMEFAAGGELYDYL 159
            ||||.|::..|:.:||. ::|.||:..:..:.|||||::.||.:|.:.:.:|:||.:|||.|.|:
Yeast    77 VAIKLIRRDTIKKDADKEIKIYREINALKHLTHPNIIYLEEVLQNSKYIGIVLEFVSGGEFYKYI 141

  Fly   160 SERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDEKGNAKIADFGLSN-VFDDQRL 223
            ..::.|.|..|.|:|.|:.:.|.|.|...:.||||||||:|||:..|..|.|||..| .|:|..|
Yeast   142 QRKRRLKESSACRLFAQLISGVNYMHYKGLVHRDLKLENLLLDKHENLVITDFGFVNEFFEDNEL 206

  Fly   224 LGTFCGSPLYASPEIVEGT-PYQGPEVDCWSLGVLLYTLVYGSMPFD-------GSNFKRLVKQI 280
            :.|.||||.||:||:|..| .|:..:.|.||.||:||.::.|.:|:|       |.:..||.|.|
Yeast   207 MKTSCGSPCYAAPELVVSTKAYEARKADVWSCGVILYAMLAGYLPWDDDHENPTGDDIARLYKYI 271

  Fly   281 SQ-----GDYYEPRKPSRASTLIRDMLTVCPRKRASIEQICSHWWVNENDNVSCLDLA-----ED 335
            :|     .:|..|    ....|:|.:|...||:|.:::.|..|.|:..::  :.|.:.     |.
Yeast   272 TQTPLKFPEYITP----IPRDLLRRILVPNPRRRINLQTIKRHVWLKPHE--AFLSIQPNYWDEH 330

  Fly   336 LANQTPV---RLDVLLSLTPATITA--------DQLVVPSA--EGAAAAKAAANERVPRSHSVGS 387
            |..:.|.   :.||....|.::..:        :.|::.|.  :...:.:.|.:.....:.|.||
Yeast   331 LQKERPKPPNKGDVGRHSTYSSSASSYSKSRDRNSLIIESTLEQHRMSPQLATSRPASPTFSTGS 395

  Fly   388 -------IRDMGPPNTEAERRI----------------LDMVAA------------GGEAALMPS 417
                   ..||...|...||..                ::.|:|            .|...:..|
Yeast   396 KVVLNDTKNDMKESNINGERTSASCRYTRDSKGNGQTQIEQVSARHSSRGNKHTSVAGLVTIPGS 460

  Fly   418 PTRTITPAQSPVQTKRKLQPTVSTENAAGTTAKKKEKPAN-SSFV------ISKDGAPLTEAPPT 475
            ||                  |..|.||..:...:..|.:: :||.      |.....|.:...||
Yeast   461 PT------------------TARTRNAPSSKLTEHVKDSSQTSFTQEEFHRIGNYHVPRSRPRPT 507

  Fly   476 IIEPQATLMEAE-TIANIP--------------EEVPVPSYSQKDMQAVGDICDLLMGTATTPAP 525
            ...|..:...|: ::|:||              :.||:.:....:...:.:...:|:      :.
Yeast   508 SYYPGLSRNTADNSLADIPVNKLGSNGRLTDAKDPVPLNAIHDTNKATISNNSIMLL------SE 566

  Fly   526 APPAPT-PVARQPTRGKLDAVVETPEEKDATKVIKKFVNK---HKTADLVNAI-NESASKAAAPV 585
            .|.|.| ||......|.|:     ..:|..|:||.| :||   ||.|:  |.. .||....:...
Yeast   567 GPAAKTSPVDYHYAIGDLN-----HGDKPITEVIDK-INKDLTHKAAE--NGFPRESIDPESTST 623

  Fly   586 SAVAPPPFVRKCSLQDESTLNKFNAERRKSRILETAEKFQPPPPVAAAPPEKPKKLSIPGV--SV 648
            ..|...|         .::.::.:.|.:...:..::.|........:....:.|:.|...:  |:
Yeast   624 ILVTKEP---------TNSTDEDHVESQLENVGHSSNKSDASSDKDSKKIYEKKRFSFMSLYSSL 679

  Fly   649 GSFKKEFEKKAT--NPPAAEGPTPGELRAQEQVAAAAAAAQEAETLSTPPPSPVVAQSLEGSDSK 711
            ...:...|.:.:  |.|......|.   .|...:......|:...||...|:|         |.|
Yeast   680 NGSRSTVESRTSKGNAPPVSSRNPS---GQSNRSNIKITQQQPRNLSDRVPNP---------DKK 732

  Fly   712 --------NSVASISLDEARRSMENSIAL-LLQAQNES--SKEVDQLCAQTET 753
                    |:.:....:...||:..|:.: .|:.:|.|  |.|.:.:.|||.|
Yeast   733 INDNRIRDNAPSYAESENPGRSVRASVMVSTLREENRSELSNEGNNVEAQTST 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	105/291 (36%)
KIN4	NP_014876.1	STKc_Kin4	44..313	CDD:270978	104/272 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345269
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840