Protein Alignment Nuak1 and PTK2

DIOPT Version :9

• Sequence 1: NP_001369005.1
• Gene: Nuak1 / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Sequence 2: NP_012593.3
• Gene: PTK2 / 853522
• SGDID: S000003820
• Length: 818
• Species: Saccharomyces cerevisiae
• Alignment Length: 704
• Identity: 151/704 - (21%)
• Similarity: 254/704 - (36%)
• Gaps: 194/704 - (27%)

  Fly     2 VISKPDGTAPNGAAGGAEAAAPTGLDAT-----------GNS--------LAHPSG-IPQDQ--- 43
            ::..|.|.:||.|.  .:.|....|:..           |||        :|:|:. :|:|.
Yeast   182 IVYNPYGISPNHAR--PDTAFADTLNTNKENDLSFYMHDGNSKIRMLPLPIANPNDFLPEDMKQY 244

  Fly    44 ----IDNIM-----SGIANTGNVKMNNHRKKLRQRFDI--IKKLGQGTYGKVQLGINKETGQEVA 97
                .||.:     ..|.:.|:.::...:...||: |:  :|||..         |..|:.:
Yeast   245 SVHLTDNFVFDTDNKPIGSGGSSEVRKVKSSYRQK-DVYALKKLNM---------IYHESPE--- 296

  Fly    98 IKTIKKCKIE---AEADLVRIRREVQIMSSVHHPNIIHIYEV----FENREKMVLVMEFAAGGEL 155
             |..|:|..|   |:          .:..:||..|..::.:|    :..| ....:||... .:|
Yeast   297 -KFYKRCSKEFIIAK----------HLSHNVHITNTFYLLKVPTTTYTTR-GWGFIMELGV-KDL 348

  Fly   156 YDYLSER---KVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDEKGNAKIADFGLSNV 217
            :. |.||   |.:...|...:|:|||..:.:||.:.|.|||||.||:|:.::|..|:.|||:|:.
Yeast   349 FQ-LMERTGWKNVPFNEKYCLFKQVAQGIKFCHDNGIAHRDLKPENVLISKEGICKLTDFGISDW 412

  Fly   218 F--------DDQRLLGTFCGSPLYASPEIVE-----------GTPYQGPEVDCWSLGVLLYTLVY 263
            :        ...:......|||.|..||::.           ..||....:|.::||::|.|::.
Yeast   413 YHVIPHDYTSPVKTCQGMIGSPPYTPPEVMYFDAKKHYPEKFQKPYNPLAMDSYALGIMLITMIN 477

  Fly   264 GSMPF-DGSNFKRLVKQIS---------QGDYYEPR---KPSRAS--TLIRDMLTVCPRKRASIE 313
            ..:|| |..|.....::..         |..::..:   ||...|  :|.|:.      |.....
Yeast   478 NIIPFIDSCNTDARFREFEVSYDNFINHQNPHFRDKGCHKPGPGSEYSLARNF------KNTDAT 536

  Fly   314 QICSHWWVNENDNVSCLDLAEDLANQTPVRLDVLLSLTPATITADQLVVPSAEGAAAAKAAANER 378
            :|.   |...:.|.:.....:||.|. |....:...:.|   ..|.||                |
Yeast   537 RIA---WRLADPNPATRYTMDDLFND-PFFQQIETCVEP---NDDDLV----------------R 578

  Fly   379 VPRSHSVGSIRDMGPPNTEAERRILDMVAAGGEAALMPSPTRTITP------AQSP-VQTKRKLQ 436
            ||......|..|....:.:|..   |..........:...|.|..|      |:|| ::.|.|::
Yeast   579 VPELRKSTSTNDFSENSLDAPH---DQEVIHTSNPFLKKETLTSKPRSMLEIAESPSLKQKSKVK 640

  Fly   437 PTVSTE--------NAAGTTAKKKEKPANSSFVISKDGAPLTEAPPTIIEPQATLMEAETIANIP 493
            .:..|:        ....|..|:::|..|    :.||.....:....|.|...|.:::......|
Yeast   641 DSAKTKTHDVGDEGGNESTKPKQQDKKEN----LKKDEVKNGDKDKVIEEATTTNVDSILEKPTP 701

  Fly   494 EEVPVPSYSQKDMQAVGDICDLLMGTATTPAPAPPAPTPVARQPTR-----GKLDAVVETPEEKD 553
            ....|.....:|...:.::..:|..|.|||....|.|.| |:..|:     ..|....|||.
Yeast   702 TSTKVEDNLSEDDSTMKELKSMLNSTPTTPTHNGPTPLP-AKAGTQLDKRMSDLSLKSETPA--- 762

  Fly   554 ATKVI-------------------------KKFVNKHKTADLVNAINESASKAA 582
            :||..                         ||.::.|  .|:.|::...:|.:|
Yeast   763 STKNFSAPNVSSSSNSLRSLGSPSVSSSKKKKVIHHH--LDITNSVTNMSSVSA 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	71/298 (24%)
PTK2	NP_012593.3	S_TKc	259..562	CDD:214567	80/339 (24%)
		STKc_HAL4_like	261..562	CDD:270896	80/337 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345260
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840