DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nuak1 and KIN1

DIOPT Version :9

Sequence 1:	NP_001369005.1	Gene:	Nuak1 / 41256	FlyBaseID:	FBgn0262617	Length:	2803	Species:	Drosophila melanogaster
Sequence 2:	NP_010407.1	Gene:	KIN1 / 851700	SGDID:	S000002529	Length:	1064	Species:	Saccharomyces cerevisiae

Alignment Length:	1051	Identity:	241/1051 - (22%)
Similarity:	378/1051 - (35%)	Gaps:	326/1051 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PTGLDATGNSLAHPSGIPQDQID--------------NIMSGIANTGNVKMNNHRKKLRQRFDII 73
            |..:....|..:|.:...:.|::              ...|.::::..:....|||.|.. ::.:
Yeast    60 PADIKYANNGNSHQAEQKERQVELEGKSRENAPKPNTTSQSRVSSSQGMPKQFHRKSLGD-WEFV 123

  Fly    74 KKLGQGTYGKVQLGINKETGQEVAIKTIKKC-------------------------KIEAEADL- 112
            :.:|.|:.|||:|..::.|.:..|:|.:.:.                         |:|.|...
Yeast   124 ETVGAGSMGKVKLAKHRYTNEVCAVKIVNRATKAFLHKEQMLPPPKNEQDVLERQKKLEKEISRD 188

  Fly   113 VRIRREVQIMSSVHHPNIIHIYEVFENREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQV 177
            .|..||..:...::||:|..::|:........::.|:.:||:|.||:.:...:.|.:||:..|.:
Yeast   189 KRTIREASLGQILYHPHICRLFEMCTLSNHFYMLFEYVSGGQLLDYIIQHGSIREHQARKFARGI 253

  Fly   178 ATAVYYCHKHKICHRDLKLENILLDEKGNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGT 242
            |:|:.|.|.:.|.|||||:|||::.:....||.||||||::|.::.|.|||||..:|:||:::..
Yeast   254 ASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDSRKQLHTFCGSLYFAAPELLKAN 318

  Fly   243 PYQGPEVDCWSLGVLLYTLVYGSMPFDGSNFKRLVKQISQGDYYEPRKPS-RASTLIRDMLTVCP 306
            ||.|||||.||.||:|:.||.|.:|||..|...|.::|.||....|:..| ...:|:..||.|.|
Yeast   319 PYTGPEVDVWSFGVVLFVLVCGKVPFDDENSSVLHEKIKQGKVEYPQHLSIEVISLLSKMLVVDP 383

  Fly   307 RKRASIEQICSHWWVNENDN--------------VSCLDL-----------AEDLANQTPVRLD- 345
            ::||:::|:..|.|:....|              :..||:           .:|:.....|.:.
Yeast   384 KRRATLKQVVEHHWMVRGFNGPPPSYLPKRVPLTIEMLDINVLKEMYRLEFIDDVEETRSVLVSI 448

  Fly   346 ------VLLSLTPATITADQLVVPSAEGAAAAKAAANERVPRSHSVGSIRDMGPPN-TEAERRIL 403
                  ||||....|:.|......|..|.|                        || ||:
Yeast   449 ITDPTYVLLSRQYWTLAAKMNAESSDNGNA------------------------PNITES----- 484

  Fly   404 DMVAAGGEAALMPSPTRTITP-------AQSPVQTK----RKLQPTVSTEN-------------- 443
                       ...|||...|       ....:..|    |..|...|.||
Yeast   485 -----------FEDPTRAYHPMISIYYLTSEMLDRKHAKIRNQQQRQSHENIEKLSEIPESVKQR 538

  Fly   444 --AAGTTAKKKEKPANSSFVISKD-GAPLTEAPPTIIEPQATLMEAETIANIPEEVPVPSYSQKD 505
              ...|||.|.|..|.   :.:|| ..|.|.......||...::....:| :||:......|:|.
Yeast   539 DVEVNTTAMKSEPEAT---LATKDTSVPFTPKNSDGTEPPLHVLIPPRLA-MPEQAHTSPTSRKS 599

  Fly   506 MQAVGDICDLLMGTATTPAPAPPAPTPVARQPTRGKLDAVVETPEEKDATKVIKKFVN------- 563
            ........:..:           :|||......:.::.:....|.||      .||.|
Yeast   600 SDNQRREMEYAL-----------SPTPQGNDYQQFRVPSTTGDPSEK------AKFGNIFRKLSQ 647

  Fly   564 -KHKTADLV-----NAINESASKAAAPVSAVAPPPFVRKCSLQDESTLN---KFNAER------- 612
             :.||.:..     |:||:...|..:...:...|.|. |.|.....|:|   |.|..|
Yeast   648 RRKKTIEQTSVNSNNSINKPVQKTHSRAVSDFVPGFA-KPSYDSNYTMNEPVKTNDSRGGNKGDF 711

  Fly   613 --------------RKSRILE------------------------TAEKFQ--------PPPPVA 631
                          |:.:|.|                        .|:||:        |.||:.
Yeast   712 PALPADAENMVEKQREKQIEEDIMKLHDINKQNNEVAKGSGREAYAAQKFEGSDDDENHPLPPLN 776

  Fly   632 AAPPEKPKKL--SIPGVSVGSFKKEFEKKATNPPAAEGPTPGELRAQEQVAAAAAAAQEAETLST 694
            .|   |.:||  |....|||..::| ..|...||......|                 :.|.:.|
Yeast   777 VA---KGRKLHPSARAKSVGHARRE-SLKYMRPPMPSSAYP-----------------QQELIDT 820

  Fly   695 PPPSPVVAQSLEGSDSKNSVASISLDEARRSMENSIALLLQAQNESSKEVDQLCAQTETIGVSEP 759
                    ..||.||...|              :|:.      |.:|:..|.:...:....::.|
Yeast   821 --------GFLESSDDNKS--------------DSLG------NVTSQTNDSVSVHSVNAHINSP 857

  Fly   760 ATQQE--RERKLKNA-RAIIGN----------------AIQPVIRRPTPF--YGI-------GNG 796
            :.::|  .|..|:.| ||..|:                ::|....:|.|.  |.|       ...
Yeast   858 SVEKELTDEEILQEASRAPAGSMPSIDFPRSLFLKGFFSVQTTSSKPLPIVRYKIMFVLRKMNIE 922

  Fly   797 FGNGMGGAVGASGATVNN-APKRAQSGSSFMGYSGATS---PGTAATSPPISGPQTAPPVLISPN 857
            |....||.|.....:.|| |.||..:..|.|..|...|   .|:...||  |.|.|.       |
Yeast   923 FKEVKGGFVCMQRFSSNNVAAKREGTPRSIMPLSHHESIRRQGSNKYSP--SSPLTT-------N 978

  Fly   858 ALAVAKQTIQQ 868
            ::...|.:|.:
Yeast   979 SIHQRKTSITE 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	94/279 (34%)
KIN1	NP_010407.1	STKc_Kin1_2	118..398	CDD:270979	94/280 (34%)
KIN1	NP_010407.1	MARK_C_like	890..1062	CDD:213377	27/109 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345264
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840