Protein Alignment Nuak1 and KIN2

DIOPT Version :9

• Sequence 1: NP_001369005.1
• Gene: Nuak1 / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Sequence 2: NP_013197.1
• Gene: KIN2 / 850785
• SGDID: S000004086
• Length: 1147
• Species: Saccharomyces cerevisiae
• Alignment Length: 1344
• Identity: 302/1344 - (22%)
• Similarity: 497/1344 - (36%)
• Gaps: 385/1344 - (28%)

  Fly     4 SKPDGTAPNGAA-GGAEAAAPTGLDATGNS-----------LAHPSGIPQD-----QIDNIMSGI 51
            ||....:|...| .....|||..|...|..           |..|:.|.|.     |..|..|
Yeast    18 SKGGSLSPTPEAFNDTRVAAPATLRMMGKQSGPRNDQQQAPLMPPADIKQGKEQAAQRQNDAS-- 80

  Fly    52 ANTGNVKMNN-HRKKLRQRFDIIKKLGQGTYGKVQLGINKETGQEVAIKTIKKC----------- 104
            ...|.|::.. ||:.|.. ::.::.:|.|:.|||:|..:::|.:...||.:.:.
Yeast    81 RPNGAVELRQFHRRSLGD-WEFLETVGAGSMGKVKLVKHRQTKEICVIKIVNRASKAYLHKQHSL 144

  Fly   105 ---KIEA---------EADLVRIR---REVQIMSSVHHPNIIHIYEVFENREKMVLVMEFAAGGE 154
               |.|:         |.::.|.:   ||..:...::||:|..::|:........::.|:.:||:
Yeast   145 PSPKNESEILERQKRLEKEIARDKRTVREASLGQILYHPHICRLFEMCTMSNHFYMLFEYVSGGQ 209

  Fly   155 LYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDEKGNAKIADFGLSNVFD 219
            |.||:.:...|.|..||:..|.:|:|:.|.|.:.|.|||||:|||::...|..||.||||||:||
Yeast   210 LLDYIIQHGSLKEHHARKFARGIASALQYLHANNIVHRDLKIENIMISSSGEIKIIDFGLSNIFD 274

  Fly   220 DQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPFDGSNFKRLVKQISQG- 283
            .::.|.|||||..:|:||:::..||.|||||.||.|::||.||.|.:|||..|...|.::|.:|
Yeast   275 YRKQLHTFCGSLYFAAPELLKAQPYTGPEVDIWSFGIVLYVLVCGKVPFDDENSSILHEKIKKGK 339

  Fly   284 -DYYEPRKPSRAS----TLIRDMLTVCPRKRASIEQICSHWWVNENDNVSCLDLAEDLANQTPVR 343
             ||     ||..|    :|:..|:.|.|.:||:::.:..|.|:|...:...   ...:.|:.|
Yeast   340 VDY-----PSHLSIEVISLLTRMIVVDPLRRATLKNVVEHPWMNRGYDFKA---PSYVPNRVP-- 394

  Fly   344 LDVLLSLTPATITADQLVVPSAEGAAAAKAAANERVPRSHSVGSIRDMGPPNTEAERRILDMVAA 408
                  |||..|.:..|                :.:.|...:..|.|        .||.|
Yeast   395 ------LTPEMIDSQVL----------------KEMYRLEFIDDIED--------TRRSL----- 424

  Fly   409 GGEAALMPSPTRTITPAQSPVQTKRKLQPTVSTENAAGTTAKKKEKPANSSFVISKDGAPLTEAP 473
                      .|.:|..:. :|..::....:|  ||.|.::.......||:            |.
Yeast   425 ----------IRLVTEKEY-IQLSQEYWDKLS--NAKGLSSSLNNNYLNST------------AQ 464

  Fly   474 PTIIEPQATLMEAETIANIPE---EVPVPSYSQKDMQAVGDICDLLMGTATTPAPAPPAPTPVAR 535
            .|:|:...|...:::..|.|:   |.|..:|     ..:..|..|:             ...|||
Yeast   465 QTLIQNHITSNPSQSGYNEPDSNFEDPTLAY-----HPLLSIYHLV-------------SEMVAR 511

  Fly   536 QPTRGK------LDAVVETPEEKDATKVIKKFVNKHKTADLVNAINESASKAAAPVSAVAPPPFV 594
            :..:.:      |.|..:..:::....:..|....:.:.|::       :|..:|...|.|.|.:
Yeast   512 KLAKLQRRQALALQAQAQQRQQQQQVALGTKVALNNNSPDIM-------TKMRSPQKEVVPNPGI 569

  Fly   595 RKC-SLQDESTLNKFNAERRKSRILETAEKFQPPPPVAAAPPEKPKKLSIPGVSVGSFKKEFEKK 658
            .:. ::....|.|..|...:             ||.....||    ||:||           |:.
Yeast   570 FQVPAIGTSGTSNNTNTSNK-------------PPLHVMVPP----KLTIP-----------EQA 606

  Fly   659 ATNPPAAEG-----PTPGELRAQEQVAAAAAAAQEAETLSTPPP----------SPVVAQSLEGS 708
            .|:|.:.:.     ...|.|:                  |||.|          ||||.:..|
Yeast   607 HTSPTSRKSSDIHTELNGVLK------------------STPVPVSGEYQQRSASPVVGEHQE-- 651

  Fly   709 DSKNSVASISLDEARRSMENSIALLLQAQNESSKEVDQLCAQTETIGVSEPATQQERERKL---- 769
              ||::..|    .||..::.     |:|:.:        .|.|.:...||.|...:..::
Yeast   652 --KNTIGGI----FRRISQSG-----QSQHPT--------RQQEPLPEREPPTYMSKSNEISIKV 697

  Fly   770 -KNARAIIGNAIQPVIRRPT--PFYGIGNGFGNGMGGAVGASGATVNNAPKRAQSGSSFMGYSGA 831
             |:....|.:.|....|.|:  |                  :...|...|.:
Yeast   698 PKSHSRTISDYIPSARRYPSYVP------------------NSVDVKQKPAK------------- 731

  Fly   832 TSPGTAATSPPI---SGPQTAPPVLISPNA-LAVAKQTIQQRIFGGGLP--SPNNQPANRRPATW 890
                ....:|||   |..|.:....:..|| |.|.||  :|::....|.  ..|:...|...|..
Yeast   732 ----NTTIAPPIRSVSQKQNSDLPALPQNAELIVQKQ--RQKLLQENLDKLQINDNDNNNVNAVV 790

  Fly   891 QPQASYSTASIFQPPQSQSSPFKMLQQQYQQRCQEDQKQSCPFTPPPSPQNAASHAYAAQANSNN 955
            ....:.::......|:.:    |:......:.....:::|..||.||.|   |:...:...|.|.
Yeast   791 DGINNDNSDHYLSVPKGR----KLHPSARAKSVGHARRESLKFTRPPIP---AALPPSDMTNDNG 848

  Fly   956 YGGNSNSGASGGSSSNSRCNSSNIGNCNTMP-----YVNYNVNSRTRPFNHNQAQDTLNTNANTS 1015
            :.|.:|.......||          |.:|:|     |.|...|..|..::....:..:...|:.:
Yeast   849 FLGEANKERYNPVSS----------NFSTVPEDSTTYSNDTNNRLTSVYSQELTEKQILEEASKA 903

  Fly  1016 ---ASATCALPVAMWLK---SSPGAEGPPTPPGAVKTSTASITLKSATLPRRKINAKAEVQ---- 1070
               :..:...|.:|:||   |.......|.|  .|:.:..|:      |.|..|:.| ||:
Yeast   904 PPGSMPSIDYPKSMFLKGFFSVQTTSSKPLP--IVRHNIISV------LTRMNIDFK-EVKGGFI 959

  Fly  1071 -LDIKPRIPEQGAP----------PQPAMRFSTEMQHPV----------ADLRSAPPREGP---- 1110
             :..:|.|.....|          ...||.....:...:          |...|:..|:|.
Yeast   960 CVQQRPSIETAAVPVITTTGVGLDSGKAMDLQNSLDSQLSSSYHSTASSASRNSSIKRQGSYKRG 1024

  Fly  1111 ---IPYSPIKTTLQARATSLEPKEHVITIQRPPTQHAYGRTSSNTTTRSGSLSRQST--VESESE 1170
               ||.:|:.|....|.:|:            |....||..|:.|   ||.||..|.  |:.:.:
Yeast  1025 QNNIPLTPLATNTHQRNSSI------------PMSPNYGNQSNGT---SGELSSMSLDYVQQQDD 1074

  Fly  1171 GTTT--ATNMS----QATITSTSQPIKKSPREF---IIPIAVEG 1205
            ..||  |.|::    |...|:||...::.|.:|   |:.:.:.|
Yeast  1075 ILTTSRAQNINNVNGQTEQTNTSGIKERPPIKFEIHIVKVRIVG 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	97/284 (34%)
KIN2	NP_013197.1	STKc_Kin1_2	97..377	CDD:270979	97/285 (34%)
		KA1	1104..1147	CDD:396635	4/15 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345263
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930