DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nuak1 and BRSK1

DIOPT Version :9

Sequence 1:	NP_001369005.1	Gene:	Nuak1 / 41256	FlyBaseID:	FBgn0262617	Length:	2803	Species:	Drosophila melanogaster
Sequence 2:	NP_115806.1	Gene:	BRSK1 / 84446	HGNCID:	18994	Length:	778	Species:	Homo sapiens

Alignment Length:	845	Identity:	221/845 - (26%)
Similarity:	349/845 - (41%)	Gaps:	258/845 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 KKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFE 138
            |.||:|..|.|:||::..|||:||||.:.:.|: :|:.|:::.||:.|:..:.||:::.:::|:|
Human    38 KTLGKGQTGLVKLGVHCITGQKVAIKIVNREKL-SESVLMKVEREIAILKLIEHPHVLKLHDVYE 101

  Fly   139 NREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDE 203
            |::.:.||:|..:||||:|||.::..||.:|||:.|||:.:|:.:||.:.|||||||.||:||||
Human   102 NKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDE 166

  Fly   204 KGNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPF 268
            |.|.:|||||::::.....||.|.||||.||.||:::|..|.|...|.||.||:|:.|:.|::||
Human   167 KNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPF 231

  Fly   269 DGSNFKRLVKQISQGDYYEPR-KPSRASTLIRDMLTVCPRKRASIEQICSHWWV--NENDNVSCL 330
            |..|.::|::::.:|.::.|. .|....:|:|.|:.|.|.||.|:|||..|.|.  .:::...||
Human   232 DDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCL 296

  Fly   331 DLA-------EDLANQTPVRLDVLLSLTPATITADQ--------------------LVV------ 362
            :.|       ..|.:...:..|||.|:.......|:                    |::
Human   297 EPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERY 361

  Fly   363 PSAEGAAAAKAAANERVPRSHSVGSIRDMGPPNTEA-------------ERR---ILDMVAAGGE 411
            ||.|.        .:..||:       |:.||....             ||:   :|.:..|||.
Human   362 PSCED--------QDLPPRN-------DVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGG 411

  Fly   412 AALMPSPT-RTITPAQ-----------------SPVQTKRKLQPTVSTENAAGTTAKKKEKPANS 458
            .:  |.|| |.:..||                 ||:.:.|....:.|.|..||..|:....|.:.
Human   412 GS--PVPTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSK 474

  Fly   459 SFVISKDGAPLTEAPPTIIEPQATLMEAETIANIPEEVPVPSYSQKDMQAVGDICDLLMGTATTP 523
            :..:...|            |:.        ....|:.|.||                  ..:||
Human   475 TQTLPSRG------------PRG--------GGAGEQPPPPS------------------ARSTP 501

  Fly   524 APAPP-APTPVARQPTRGKLDAVVETPEEKDATKVIKKFVNKHKTADLVNAINESASKAAAPVSA 587
            .|.|| :|......|    |.:.:.||.                           ||....|  .
Human   502 LPGPPGSPRSSGGTP----LHSPLHTPR---------------------------ASPTGTP--G 533

  Fly   588 VAPPPF-----------VRKCSLQDESTLNKFNAERRKSRILETAEKFQPPPPVAAAPPEKPKK- 640
            ..|||.           .|..|::: |.|......|||.:: .|||:.....|.::  ||..|:
Human   534 TTPPPSPGGGVGGAAWRSRLNSIRN-SFLGSPRFHRRKMQV-PTAEEMSSLTPESS--PELAKRS 594

  Fly   641 ----------------------------------LSIPGVSVG-----SFKKEFEKKATNPPAAE 666
                                              ||||.:|..     ||:.|::       |:.
Human   595 WFGNFISLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYK-------ASG 652

  Fly   667 GPTPGELRAQEQVAAAAAAAQEAETLSTPPPSPVVAQSLEGSDSKNSVASISLD-------EARR 724
            ||:..:...:.||..:::..        |.|||    ..:||.. ..:.|::..       ..:|
Human   653 GPSVFQKPVRFQVDISSSEG--------PEPSP----RRDGSGG-GGIYSVTFTLISGPSRRFKR 704

  Fly   725 SMENSIALLLQAQNESSKEVDQLCAQTETIGVSEPATQQERERKLKNARAIIGNAIQPVIRRPTP 789
            .:|...|.||...::.|.   |..|..:....:.||....|             ::||...||.|
Human   705 VVETIQAQLLSTHDQPSV---QALADEKNGAQTRPAGAPPR-------------SLQPPPGRPDP 753

Fly 790 789
Human 754 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	109/247 (44%)
BRSK1	NP_115806.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		STKc_BRSK1_2	32..285	CDD:270983	109/247 (44%)
		UBA_BRSK	314..367	CDD:270525	9/60 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..548		51/273 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	719..778		11/51 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155246
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840