DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nuak1 and Brsk2

DIOPT Version :9

Sequence 1:	NP_001369005.1	Gene:	Nuak1 / 41256	FlyBaseID:	FBgn0262617	Length:	2803	Species:	Drosophila melanogaster
Sequence 2:	NP_001009930.1	Gene:	Brsk2 / 75770	MGIID:	1923020	Length:	719	Species:	Mus musculus

Alignment Length:	749	Identity:	202/749 - (26%)
Similarity:	325/749 - (43%)	Gaps:	205/749 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 KKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFE 138
            |.||:|..|.|:|||:..|.|:||||.:.:.|: :|:.|:::.||:.|:..:.||:::.:::|:|
Mouse    24 KTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKL-SESVLMKVEREIAILKLIEHPHVLKLHDVYE 87

  Fly   139 NREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDE 203
            |::.:.||:|..:||||:|||.::..||.:|||:.|||:.:|:.:||.|.|||||||.||:||||
Mouse    88 NKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDE 152

  Fly   204 KGNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPF 268
            :.|.:|||||::::.....||.|.||||.||.||::.|..|.|.:.|.||.||:|:.|:.|::||
Mouse   153 RNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPF 217

  Fly   269 DGSNFKRLVKQISQGDYYEPR-KPSRASTLIRDMLTVCPRKRASIEQICSHWWVNENDNVSCLDL 332
            |..|.::|::::.:|.::.|. .|....:|:|.|:.|...:|.::|.|..|.|.....|
Mouse   218 DDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKN------ 276

  Fly   333 AEDLANQTPVRLDVLLSLTPATITADQLVVPSAEGAAAAKAAANERVPRSHSVGSIRDMG----- 392
              :...:.|:...|.:...|:....|..|:.|                 .||:|..||..
Mouse   277 --EPEPEQPIPRKVQIRSLPSLEDIDPDVLDS-----------------MHSLGCFRDRNKLLQD 322

  Fly   393 -------------------------------PPNTEAE--RRILD--MVAAGGEAALMPSPTR-- 420
                                           ||..|.:  |:.:|  |:...|:.    .|.|
Mouse   323 LLSEEENQEKMIYFLLLDRKERYPSHEDEDLPPRNEIDPPRKRVDSPMLNRHGKR----RPERKS 383

  Fly   421 ----TITPAQSPVQTKRKL---QPTVSTENAAGTTAKKKEKPANSSFVI---SKDGAPLTEAPPT 475
                ::|...|||..:|.:   |....:.:.:|.::.....|.:|..|.   |..|:||    ||
Mouse   384 MEVLSVTDGGSPVPARRAIEMAQHGQRSRSISGASSGLSTSPLSSPRVTPHPSPRGSPL----PT 444

  Fly   476 IIEPQATLMEAETIANIPEEVPVPSYSQKDMQAVGDICDLLMGTATTPAPAPPAPTPVARQPTRG 540
               |:.|.:      :.|:|.|                      |.||.|.||:...|...|.|.
Mouse   445 ---PKGTPV------HTPKESP----------------------AGTPNPTPPSSPSVGGVPWRT 478

  Fly   541 KLDAV----------------VETPEE------KDATKVIKK-----FVNKHK------------ 566
            :|:::                |.||||      :.:.::.||     |:|..|
Mouse   479 RLNSIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFINLEKEEQIFVVIKDKP 543

  Fly   567 ----TADLVNAINESASKAAAPVSAVA----------PPPFVRKCSLQDEST------LNKFNA- 610
                .||:|:|.....|.:.:.:|..:          |..|.:....|.:.|      ..|.|.
Mouse   544 LSSIKADIVHAFLSIPSLSHSVISQTSFRAEYKATGGPAVFQKPVKFQVDITYTEGGEAQKENGI 608

  Fly   611 -----------ERRKSRILETAEKFQPPPPVAAAPPEKPKKLSIPG------VSVGSFKKEFEKK 658
                       .||..|::||.:      ....:..::|....:..      |..|...|..||
Mouse   609 YSVTFTLLSGPSRRFKRVVETIQ------AQLLSTHDQPSAQHLSDTTNCMEVMTGRLSKCDEK- 666

  Fly   659 ATNPPAAEGP-TPGELRAQEQVAAAAAAAQEAET 691
              |..||:.| ||.:..|...:..:|||....:|
Mouse   667 --NGQAAQAPSTPAKRSAHGPLGDSAAAGPGGDT 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	105/247 (43%)
Brsk2	NP_001009930.1	STKc_BRSK1_2	18..271	CDD:270983	105/247 (43%)
Brsk2	NP_001009930.1	UBA_BRSK	298..351	CDD:270525	8/69 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845722
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840