DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nuak1 and Nuak2

DIOPT Version :9

Sequence 1:	NP_001369005.1	Gene:	Nuak1 / 41256	FlyBaseID:	FBgn0262617	Length:	2803	Species:	Drosophila melanogaster
Sequence 2:	NP_001181954.1	Gene:	Nuak2 / 74137	MGIID:	1921387	Length:	639	Species:	Mus musculus

Alignment Length:	800	Identity:	245/800 - (30%)
Similarity:	353/800 - (44%)	Gaps:	243/800 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VISKPDGTAPNGAAGGAEAAAP--TGLDATGNSLAHPSGIPQDQIDNIMSGIANTGNVKMNNHRK 64
            ::.:| ..||:.:|..:|:|.|  .||      :..|..:.:.|.            ||.::|:.
Mouse     6 LLQRP-SQAPSASALASESARPLADGL------IKSPKPLMKKQA------------VKRHHHKH 51

  Fly    65 KLRQRFDIIKKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPN 129
            .||.|::.::.||:||||||:.. .:.:|:.||||:|:|.||:.|.||:.||||::||||::||:
Mouse    52 NLRHRYEFLETLGKGTYGKVKKA-RESSGRLVAIKSIRKDKIKDEQDLLHIRREIEIMSSLNHPH 115

  Fly   130 IIHIYE--------VFENREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHK 186
            ||.|:|        ||||..|:|:|||:|:.|:||||:|||..|:|.:||..|||:.:|::|||:
Mouse   116 IIAIHEVGRSRLVTVFENSSKIVIVMEYASRGDLYDYISERPRLSERDARHFFRQIVSALHYCHQ 180

  Fly   187 HKICHRDLKLENILLDEKGNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDC 251
            :.|.||||||||||||..||.|||||||||::...:.|.||||||||||||||.|.||.|||||.
Mouse   181 NGIVHRDLKLENILLDANGNIKIADFGLSNLYHKGKFLQTFCGSPLYASPEIVNGKPYVGPEVDS 245

  Fly   252 WSLGVLLYTLVYGSMPFDGSNFKRLVKQISQGDYYEPRKPSRASTLIRDMLTVCPRKRASIEQIC 316
            ||||||||.||:|:|||||.:.|.||||||.|.|.||.|||.|..|||.:|.|.|.:||::|.:.
Mouse   246 WSLGVLLYILVHGTMPFDGQDHKTLVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATLEDVA 310

  Fly   317 SHWWVNENDNVSCLDLAEDLANQTPVRLDVLLSLTPATITADQLVVPSAEGAAAAKAAANERVPR 381
            ||||||       ......:..|..:|               :...||.:...|:.|....|..|
Mouse   311 SHWWVN-------WGYTTGVGEQEALR---------------EGGHPSGDFGRASMADWLRRSSR 353

  Fly   382 SHSVGSIRDMGPPNTEAERRILDM----VAAGGEAALMPSPTRTITPAQSPVQTKRKLQPTVSTE 442
                        |..|...::...    |..||.         |:...:.....|:..:.....:
Mouse   354 ------------PLLENGAKVCSFFKQHVPGGGS---------TVPGLERQHSLKKSRKENDMAQ 397

  Fly   443 NAAGTTAK-KKEKPANSSFVISKDGAPLTEAPPTIIEPQATLMEAETIANIPEEV-PVPSYSQKD 505
            |..|..|: ...:|..||.          :.|..|::.:::....| :...|:|: |||.
Mouse   398 NLQGDPAEDTSSRPGKSSL----------KLPKGILKKKSSTSSGE-VQEDPQELRPVPD----- 446

  Fly   506 MQAVGDICDLLMGTATTPAPAPPAPTPVARQPTRGKLDAVVETPEEKDATKVIKKFVNKHKTADL 570
                              .|..|.|. |:..|.:|                ::||
Mouse   447 ------------------TPGQPVPA-VSLLPRKG----------------ILKK---------- 466

  Fly   571 VNAINESASKAAAPVSAVAPPPFVRKCSLQDESTLNKFNAERRKSRILETAEKFQPPPPVAAAPP 635
                                       |.|.||.............:|:.::.|....||....|
Mouse   467 ---------------------------SRQRESGYYSSPEPSESGELLDASDVFVSGDPVEQKSP 504

  Fly   636 EKP---------KKLSIPGVSVGSFKKEFEKKATNPPAAEGPTPGELRAQEQVAAAAAAAQEAET 691
            :..         .||:      |.|.:         .|.||.||....:.:|:|::..||:
Mouse   505 QASGLLLHRKGILKLN------GKFSR---------TALEGTTPSTFGSLDQLASSHPAAR---- 550

  Fly   692 LSTPPPSPVVAQSLEGSDSKNSVASISLDEARRSMENSIALLLQAQNESSKEVDQL--------- 747
                |..|      .|:.|::|:.                        ||:..|||
Mouse   551 ----PSRP------SGAVSEDSIL------------------------SSESFDQLDLPERLPET 581

  Fly   748 ----CAQTETI-GVSEPATQ 762
                |...:.: |:.:|.::
Mouse   582 PLRGCVSVDNLRGLEQPPSE 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	154/260 (59%)
Nuak2	NP_001181954.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		4/15 (27%)
		PKc_like	53..315	CDD:304357	156/262 (60%)
		S_TKc	57..315	CDD:214567	153/258 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..485		30/209 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..575		18/83 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845720
Domainoid	1	1.000	331	1.000	Domainoid score	I1148
eggNOG	1	0.900	-	-		E1_KOG0611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002307
OrthoInspector	1	1.000	-	-		otm43589
orthoMCL	1	0.900	-	-		OOG6_106932
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5135
SonicParanoid	1	1.000	-	-		X2001
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.670