Protein Alignment Nuak and Prkaa1

DIOPT Version :10

• Sequence 1: NP_001369005.1
• Gene: Nuak / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Sequence 2: NP_062015.2
• Gene: Prkaa1 / 65248
• RGDID: 3387
• Length: 559
• Species: Rattus norvegicus
• Alignment Length: 532
• Identity: 170/532 - (31%)
• Similarity: 251/532 - (47%)
• Gaps: 126/532 - (23%)

  Fly    76 LGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFENR 140
            ||.||:|||::|.::.||.:||:|.:.:.||.:...:.:||||:|.:....||:||.:|:|....
  Rat    33 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTP 97

  Fly   141 EKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDEKG 205
            ..:.:|||:.:||||:||:.:...|.|:|:||:|:|:.:.|.|||:|.:.|||||.||:|||...
  Rat    98 SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHM 162

  Fly   206 NAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPFDG 270
            |||||||||||:..|...|.|.||||.||:||::.|..|.|||||.||.||:||.|:.|::|||.
  Rat   163 NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDD 227

  Fly   271 SNFKRLVKQISQGDYYEPR--KPSRASTLIRDMLTVCPRKRASIEQICSHWW------------- 320
            .:...|.|:|..|.:|.|:  .||..| |::.||.|.|.|||:|:.|..|.|
  Rat   228 DHVPTLFKKICDGIFYTPQYLNPSVIS-LLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPED 291

  Fly   321 ---------------------VNENDNVSCL-----------------------DLAED------ 335
                                 .:|.:.:|||                       :.|:|
  Rat   292 PSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATS 356

  Fly   336 ----------LANQTPVRLDVLLSLTP-ATITADQLVVPSA--EGAAAAK--------AAANE-- 377
                      |....|.|:..|::.|| |..|.|:|....:  :|...||        :..|:
  Rat   357 PPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIM 421

  Fly   378 ----------------------RVPRSHSVGS-IRDMGPPNTEAERR--ILDMVAAGGEAALMPS 417
                                  ||.|.:.|.| ...|.....:.:.|  :||..:...|  :..:
  Rat   422 AEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDE--ITEA 484

  Fly   418 PTRTITPAQS-PVQTKRKLQPTVSTENAAGTTAKKKEKPANSSFVISKDGAPLTEAPPTIIEPQA 481
            .:.|.||.:| .:...|..|.:.|...|.|    |..:.:.:|.|.|.|.:|:..||    .|.:
  Rat   485 KSGTATPQRSGSISNYRSCQRSDSDAEAQG----KPSEVSLTSSVTSLDSSPVDVAP----RPGS 541

  Fly   482 TLME-AETIANI 492
            ..:| .|..||:
  Rat   542 HTIEFFEMCANL 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nuak	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	118/280 (42%)
Prkaa1	NP_062015.2	STKc_AMPK_alpha	24..279	CDD:270981	117/246 (48%)
		UBA_AID_AAPK1	296..360	CDD:270586	6/63 (10%)
		AIS. /evidence=ECO:0000250|UniProtKB:Q13131	302..381		10/78 (13%)
		AMPKA1_C	404..557	CDD:213384	35/160 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	484..536		15/55 (27%)