Protein Alignment Nuak and Mark2

DIOPT Version :10

• Sequence 1: NP_001369005.1
• Gene: Nuak / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Sequence 2: XP_006230941.1
• Gene: Mark2 / 60328
• RGDID: 708483
• Length: 841
• Species: Rattus norvegicus
• Alignment Length: 805
• Identity: 229/805 - (28%)
• Similarity: 354/805 - (43%)
• Gaps: 157/805 - (19%)

  Fly    27 DATGNSLAHPSGIPQDQIDNIMSGIANTGNVKMNNHRKKLRQRFDIIKKLGQGTYGKVQLGINKE 91
            |....:|.|....|..: .|::.|..:..:.....|....|    ::|.:|:|.:.||:|..:..
  Rat    15 DTEQPTLGHLDSKPSSK-SNMLRGRNSATSADEQPHIGNYR----LLKTIGKGNFAKVKLARHIL 74

  Fly    92 TGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFENREKMVLVMEFAAGGELY 156
            ||:|||:|.|.|.::.: :.|.::.|||:||..::||||:.::||.|..:.:.||||:|:|||::
  Rat    75 TGKEVAVKIIDKTQLNS-SSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVF 138

  Fly   157 DYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDEKGNAKIADFGLSNVFDDQ 221
            |||.....:.|:|||..|||:.:||.|||:..|.|||||.||:|||...|.||||||.||.|...
  Rat   139 DYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFG 203

  Fly   222 RLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPFDGSNFKRLVKQISQGDYY 286
            ..|.||||||.||:||:.:|..|.|||||.|||||:|||||.||:||||.|.|.|.:::.:|.|
  Rat   204 NKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY- 267

  Fly   287 EPRKPSRAST----LIRDMLTVCPRKRASIEQICSHWWVN---ENDNVSCLDLAEDLAN-QTPVR 343
              |.|...||    |::..|.:.|.||.::|||....|:|   |:|.:.  ...|.|.: :.|.|
  Rat   268 --RIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELK--PYVEPLPDYKDPRR 328

  Fly   344 LDVLLSL--TPATITADQLVVPSAEGAAAAKAAANERVPRSHSVGSIRDMGPPNTEAERRILDMV 406
            .::::|:  |...| .|.||     |....:..|...:           :|..::|.|
  Rat   329 TELMVSMGYTREEI-QDSLV-----GQRYNEVMATYLL-----------LGYKSSELE------- 369

  Fly   407 AAGGEAALMPSPTRTITPAQSPVQTKRKLQPTVSTENAAGTTAKKKEKPANSSFVISKDGAPLTE 471
              |....|.|.|:..:|.:.:| ....|:|.:||        |..|::.::.            :
  Rat   370 --GDTITLKPRPSADLTNSSAP-SPSHKVQRSVS--------ANPKQRRSSD------------Q 411

  Fly   472 APPTIIEPQATLMEAETIANIPEEVPVPSYSQKDMQAVGDICDLLMGTATTPAPAPPAPTPVARQ 536
            |.|.|  |.:.....:|.:|..|       :::..:..|     ...::|...||.|.|
  Rat   412 AVPAI--PTSNSYSKKTQSNNAE-------NKRPEEETG-----RKASSTAKVPASPLP------ 456

  Fly   537 PTRGKLDAVVETPEEKDATKVIKKFVNKHKTADLVNAIN-------------------ESASKAA 582
                .||....|| ......|:....|:.:.:.|::..:                   .|.:.|:
  Rat   457 ----GLDRKKTTP-TPSTNSVLSTSTNRSRNSPLLDRASLGQASIQNGKDSLTMPGSRASTASAS 516

  Fly   583 APVSAVAPPPFVRKCSLQDESTLNKFNAERRKSRILETAEKFQPPPPVAA---APPEKPKKLSIP 644
            |.|||..|        .|.:.:::......:.|.:..|....:.|.|..|   .|...|...:|.
  Rat   517 AAVSAARP--------RQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNIS 573

  Fly   645 GVSVGSFKKEFEKKATNPPAAEGPTPGELRAQEQVAAAAAAAQEAETLSTPPPSPV-VAQSLEGS 708
            ..|....:..|.:..::......   |:||....        |:.......|.||. .:|...|:
  Rat   574 SSSGAPDRTNFPRGVSSRSTFHA---GQLRQVRD--------QQNLPFGVTPASPSGHSQGRRGA 627

  Fly   709 DSKNSVASISLDEARRSMENSIALLLQAQNESSKEVDQL-----CAQTETIGVSEPATQQERERK 768
             |.:..:..:....||::....|...:.....|:|:|.|     |.|.       ...|||....
  Rat   628 -SGSIFSKFTSKFVRRNLSFRFARRCRLSLPKSQELDILRQGSFCRQA-------LVEQQEAHTL 684

  Fly   769 LKNA----RAIIGNAIQP--VIRRP 787
            |.:.    ||.:   :||  |:.||
  Rat   685 LLHLPSWDRAWL---VQPGHVLCRP 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nuak	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	122/256 (48%)
Mark2	XP_006230941.1	STKc_MARK	52..304	CDD:270974	123/259 (47%)
		UBA_MARK2	322..363	CDD:270589	10/57 (18%)
		MARK2_C	742..840	CDD:213386