Protein Alignment Nuak and mark2

DIOPT Version :10

• Sequence 1: NP_001369005.1
• Gene: Nuak / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Sequence 2: XP_012808991.1
• Gene: mark2 / 594939
• XenbaseID: XB-GENE-876451
• Length: 792
• Species: Xenopus tropicalis
• Alignment Length: 669
• Identity: 199/669 - (29%)
• Similarity: 297/669 - (44%)
• Gaps: 166/669 - (24%)

  Fly    29 TGNSLAH------------PSGIPQDQIDNIMSGIANTGNVK--MNNHRKKLRQRFDIIKKLGQG 79
            |...|||            .||..:..:....:.||.|.:.:  :.|:|        ::|.:|:|
 Frog    17 TNPLLAHEPALGHADQKTSSSGSSKPNMLRCRTSIATTADEQPHIGNYR--------LLKTIGKG 73

  Fly    80 TYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFENREKMV 144
            .:.||:|..:..||:|||:|.|.|.::.: :.|.::.|||:||..::||||:.::||.|..:.:.
 Frog    74 NFAKVKLARHVLTGKEVAVKIIDKTQLNS-SSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLY 137

  Fly   145 LVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDEKGNAKI 209
            ||||:|:|||::|||.....:.|:|||..|||:.:||.|||:..|.|||||.||:|||...|.||
 Frog   138 LVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKLIVHRDLKAENLLLDSDMNIKI 202

  Fly   210 ADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPFDGSNFK 274
            ||||.||.|.....|.||||||.||:||:.:|..|.|||||.|||||:|||||.||:||||.|.|
 Frog   203 ADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLK 267

  Fly   275 RLVKQISQGDYYEPRKPSRAST----LIRDMLTVCPRKRASIEQICSHWWVN---ENDNVSCL-- 330
            .|.:::.:|.|   |.|...||    |::..|.:.|.||.::|||....|:|   |.|.:...
 Frog   268 ELRERVLRGKY---RIPFYMSTDCENLLKKFLILNPAKRGTLEQIMRDRWMNVGHEEDELKPYVE 329

  Fly   331 ----------------------DLAEDLANQ--TPVRLDVLL-----------SLT-----PATI 355
                                  ::::.|.||  ..|....||           :||     |..:
 Frog   330 PIPDYKDPKRTELMITMGYTREEISDSLVNQKYNEVMATYLLLGYKSSETDNDNLTLKPRPPPDV 394

  Fly   356 TADQLVVPSAEGAAAAKAAANER-----------VPRSHSVGSIRDMGPPNTEAERRILDMVAAG 409
            |  ..:.||.........:||.:           :|.|:|...   ....|....||..|...:|
 Frog   395 T--NSIAPSPAHKVQRSVSANPKQRRLSDQAGPAIPNSNSYSK---KTQSNNAENRRSEDDKESG 454

  Fly   410 GEAA----LMPSP-------TRTITPA-------------QSPVQTKRKLQPTVSTEN------A 444
            .:::    :.|||       ..|.||:             .||:..:..|.|. |.:|      .
 Frog   455 RKSSSTVRVPPSPLSGLDRKKTTPTPSTNSVLSTGTNRSRNSPMLDRASLVPG-SVQNGKDSFST 518

  Fly   445 AGTTAKKKEKPANSSFVISKDGAPLTEAPPTIIEPQATL---MEAETIANIPEEVPVPSYSQKDM 506
            .|:.|.....||.|:.:.....:..|...|:  :|..:|   .|.:..:..|:.|||.|.|..::
 Frog   519 PGSRASTASAPATSARIRQHQKSMSTSVHPS--KPAPSLDGNCEVQRPSTAPQRVPVASPSAHNI 581

  Fly   507 QAVG-------------------------DICDLLMGTATTPAPAPPAPTPVARQPTRGKLDAVV 546
            .:..                         |..:|..|:.   :||.|:.....|:...|.:
 Frog   582 SSAATERTNFPRGVSSRSTFHAGQVRQARDQQNLGFGSV---SPASPSGNSQGRRGATGSI---- 639

  Fly   547 ETPEEKDATKVIKKFVNKH 565
                   .:|...|||.::
 Frog   640 -------FSKFTSKFVRRN 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nuak	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	122/256 (48%)
mark2	XP_012808991.1	STKc_MARK	63..315	CDD:270974	124/263 (47%)
		UBA_MARK2	333..374	CDD:270589	6/40 (15%)
		MARK2_C	693..791	CDD:213386