DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nuak and MARK4

DIOPT Version :10

Sequence 1:NP_001369005.1 Gene:Nuak / 41256 FlyBaseID:FBgn0262617 Length:2803 Species:Drosophila melanogaster
Sequence 2:NP_001186796.1 Gene:MARK4 / 57787 HGNCID:13538 Length:752 Species:Homo sapiens


Alignment Length:751 Identity:219/751 - (29%)
Similarity:322/751 - (42%) Gaps:167/751 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 NSLAHPSGIPQDQIDNIMSGIANTGNVKMNNHRKKLRQRFDIIKKLGQGTYGKVQLGINKETGQE 95
            ||:|   ..|::|        .:.||             :.:::.:|:|.:.||:|..:..||:|
Human    44 NSIA---SCPEEQ--------PHVGN-------------YRLLRTIGKGNFAKVKLARHILTGRE 84

  Fly    96 VAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFENREKMVLVMEFAAGGELYDYLS 160
            ||||.|.|.::. .:.|.::.|||:||..::||||:.::||.|..:.:.||||:|:.||::|||.
Human    85 VAIKIIDKTQLN-PSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLV 148

  Fly   161 ERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDEKGNAKIADFGLSNVFDDQRLLG 225
            ....:.|:|||..|||:.:||:|||:..|.|||||.||:|||.:.|.||||||.||.|.....|.
Human   149 SHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLD 213

  Fly   226 TFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPFDGSNFKRLVKQISQGDYYEPRK 290
            ||||||.||:||:.:|..|.|||||.|||||:|||||.||:||||.|.|.|.:::.:|.|   |.
Human   214 TFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKY---RV 275

  Fly   291 PSRAST----LIRDMLTVCPRKRASIEQICSHWWVN---ENDNVSCLDLAEDLANQTPVRLDVLL 348
            |...||    ::|..|.:.|.||.::|||....|:|   |.:.:......|:....|. |::|::
Human   276 PFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTK-RIEVMV 339

  Fly   349 -----------SLTPA---TITADQLVV--PSAEG---AAAAKAAANERVPRSHSVGSIRDMGPP 394
                       |||..   .:||..|::  .:.||   .|...|.|..|.|...:.|:....|..
Human   340 GMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTS 404

  Fly   395 NTEA----------ERRILDMVAAGGEAALMPSPTRTITPAQSPVQTKRKLQPTVSTENAAGTTA 449
            :::.          :||..|...        |||. .:.|.:||..|              |...
Human   405 HSKGQRSSSSTYHRQRRHSDFCG--------PSPA-PLHPKRSPTST--------------GEAE 446

  Fly   450 KKKEKPANSSFVISKDGAPLTEAPPTIIEPQATLMEAETIANIPEEVPVPSYSQKDMQAVGDICD 514
            .|:|:........|..|:.....||:  .|..:.......|.|||.       :||         
Human   447 LKEERLPGRKASCSTAGSGSRGLPPS--SPMVSSAHNPNKAEIPER-------RKD--------- 493

  Fly   515 LLMGTATTPAPAPPAPTPVARQPTRGKLDAVVETPEEKDATKVIKKFVNKHKTADLVNA-INESA 578
                :.:||...||:      ..||.......|.|             ...:.:.|.|. .|.|.
Human   494 ----STSTPNNLPPS------MMTRRNTYVCTERP-------------GAERPSLLPNGKENSSG 535

  Fly   579 SKAAAPVS----AVAPPPFVRKCSLQDESTLNKFNAERRKSRIL-----ETAEKFQPPPP----- 629
            :....|.|    ::|||...|....:..:..:.|:..:.:.|..     ...:...|..|     
Human   536 TPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHE 600

  Fly   630 VAAAPPEKPK-----------KLS---------IPGVSVGSFKKEFEKKATNPPAAEGPTPGEL- 673
            .|..|..:|:           ||:         |.|..|.|....:::..|.|.....|...:| 
Human   601 AAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPWSVKLT 665

  Fly   674 --RAQEQVAAAAAAAQEAETLSTPPPSPVVAQSLEG 707
              |..|.:.||...|..|.......|.|.:...|.|
Human   666 SSRPPEALMAALRQATAAARCRCRQPQPFLLACLHG 701

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NuakNP_001369005.1 STKc_NUAK 68..321 CDD:270975 121/256 (47%)
MARK4NP_001186796.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36
STKc_MARK 58..310 CDD:270974 122/268 (46%)
UBA_MARK3_4 328..370 CDD:270590 9/42 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 385..614 54/292 (18%)
MARK4_C 654..752 CDD:213382 12/48 (25%)
Blue background indicates that the domain is not in the aligned region.

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