DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nuak1 and nuak1b

DIOPT Version :9

Sequence 1:	NP_001369005.1	Gene:	Nuak1 / 41256	FlyBaseID:	FBgn0262617	Length:	2803	Species:	Drosophila melanogaster
Sequence 2:	XP_689990.2	Gene:	nuak1b / 561496	ZFINID:	ZDB-GENE-131120-18	Length:	613	Species:	Danio rerio

Alignment Length:	738	Identity:	247/738 - (33%)
Similarity:	351/738 - (47%)	Gaps:	174/738 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DATGNSLAHPSGIP--QDQIDNIMSGIANTGNVKMNNHRKKLRQRFDIIKKLGQGTYGKVQLGIN 89
            |.:|.|:.|.:..|  ..::....||      ||.::|:..|:.|:::::.||:||||||:..|.
Zfish     9 DPSGPSVVHVAEAPGGPGEVKRSNSG------VKKHHHKHNLKHRYELLETLGRGTYGKVRKAIE 67

  Fly    90 KETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFENREKMVLVMEFAAGGE 154
            :.:|:|||||:|:|.||:.|.|:|.||||::||||:.||:||.|||||||::|:|:|||:|:.||
Zfish    68 RHSGREVAIKSIRKEKIKDEQDMVHIRREIEIMSSLRHPHIISIYEVFENKDKIVIVMEYASKGE 132

  Fly   155 LYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDEKGNAKIADFGLSNVFD 219
            ||||:|||:.|||.|.|..|||:.:||:||||:.:.||||||||:||||..|.|||||||||::.
Zfish   133 LYDYISERRRLTERETRHFFRQIVSAVHYCHKNGVVHRDLKLENVLLDENCNIKIADFGLSNLYH 197

  Fly   220 DQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPFDGSNFKRLVKQISQGD 284
            ..:||.||||||||||||||.|.||:|||||.|:|||||||||||||||||.:.|.|::|||.|:
Zfish   198 KDKLLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGSMPFDGGDHKNLIRQISNGE 262

  Fly   285 YYEPRKPSRASTLIRDMLTVCPRKRASIEQICSHWWVN---ENDNVSCLDLAEDLANQTPVRLDV 346
            |.||.:.|.|..|||.||.|.|.:||::|.|.:|||||   :|....|
Zfish   263 YREPSQSSDARGLIRWMLMVNPERRATVEDIANHWWVNWGWKNSVCDC----------------- 310

  Fly   347 LLSLTPATITADQLVVPSAEGAAAAKAAANERVPRSHSVGSIRDMGPPNTEAERRILDMVAAGGE 411
                                                   .|.||.|.|..   .|::|.     :
Zfish   311 ---------------------------------------ESQRDNGSPML---ARLIDW-----Q 328

  Fly   412 AALMPSPTRTITP------AQSPVQTKRKLQPTVSTENAAGTTAKKKEKPANSSFVISKDGAPLT 470
            ....|.||:.|..      .|.|.::|::....||..|...:...|:.|....:....:..:|
Zfish   329 NRTEPRPTKAIRSEPFLLVRQRPKKSKKENDVGVSHCNGEDSLGLKRPKGILKTRTSEEQRSP-- 391

  Fly   471 EAPPTIIEPQATLMEAETIANIPEEVPVPSYSQKDMQAVGDICDLLMGTATTPAPAPPAPTPVAR 535
                       :|.|.|:.|..||:...|.....|.:           ...:|:.:      |:.
Zfish   392 -----------SLEEIESGAGTPEKESGPDGEDGDEE-----------QGNSPSKS------VSI 428

  Fly   536 QPTRGKL-------DAVVETPEEKDATKVIKKFVNKHKTADLVNAINESASKAAAPVSAVAPPPF 593
            .|.:|.|       .....:||..:::.::                    |....|::|.:||.
Zfish   429 LPKKGILKNNQQRESGYYSSPERSESSDLL--------------------SGNITPLAASSPPK- 472

  Fly   594 VRKCSLQDESTLNKFNAERRKSRILETAEKFQ-----PPPPVAAAPPEKPKKLSIPGVSVGSFKK 653
                           .|..||. ||:...|:.     ||..|...|......||.......|..:
Zfish   473 ---------------RAVGRKG-ILKRNGKYSTYSGAPPLGVLGEPAPSDSGLSRSQSRPSSIVR 521

  Fly   654 EFEKKATNPP--AAEGPTPGELRAQEQVAAAAAAAQ-----EAETLSTPPP--SPVVAQSLEGSD 709
            |.....||..  :.|.|.|   |.:..:.:..:|..     ..:.|...||  |....:..:||.
Zfish   522 EESDTITNSSFCSTEWPPP---RTRPNIRSCLSAENLLQLANFKGLQAAPPMHSGKFNRDAQGSP 583

  Fly   710 SKNSVASI--SLDEARRSMENSI 730
            ..||..|:  .||:..:..:.::
Zfish   584 GDNSSFSLLGDLDDMTQVYQQAL 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	159/252 (63%)
nuak1b	XP_689990.2	STKc_NUAK	47..299	CDD:270975	159/251 (63%)
nuak1b	XP_689990.2	S_TKc	48..299	CDD:214567	158/250 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590347
Domainoid	1	1.000	341	1.000	Domainoid score	I1050
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002307
OrthoInspector	1	1.000	-	-		otm26066
orthoMCL	1	0.900	-	-		OOG6_106932
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2001
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.740