Protein Alignment Nuak1 and PRKAA1

DIOPT Version :9

• Sequence 1: NP_001369005.1
• Gene: Nuak1 / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Sequence 2: NP_996790.3
• Gene: PRKAA1 / 5562
• HGNCID: 9376
• Length: 574
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 169/547 - (30%)
• Similarity: 250/547 - (45%)
• Gaps: 141/547 - (25%)

  Fly    76 LGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFENR 140
            ||.||:|||::|.::.||.:||:|.:.:.||.:...:.:||||:|.:....||:||.:|:|....
Human    33 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTP 97

  Fly   141 EKMVLVMEFAAGGELYDYLSER---------------KVLTEEEARRIFRQVATAVYYCHKHKIC 190
            ..:.:|||:.:||||:||:.:.               |.|.|:|:||:|:|:.:.|.|||:|.:.
Human    98 SDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVV 162

  Fly   191 HRDLKLENILLDEKGNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLG 255
            |||||.||:|||...|||||||||||:..|...|.|.||||.||:||::.|..|.|||||.||.|
Human   163 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSG 227

  Fly   256 VLLYTLVYGSMPFDGSNFKRLVKQISQGDYYEPR--KPSRASTLIRDMLTVCPRKRASIEQICSH 318
            |:||.|:.|::|||..:...|.|:|..|.:|.|:  .||..| |::.||.|.|.|||:|:.|..|
Human   228 VILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVIS-LLKHMLQVDPMKRATIKDIREH 291

  Fly   319 WW----------------------------------VNENDNVSCL------------------- 330
            .|                                  .:|.:.:|||
Human   292 EWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDN 356

  Fly   331 ----DLAED----------------LANQTPVRLDVLLSLTP-ATITADQLVVPSA--EGAAAAK 372
                :.|:|                |....|.|:..|::.|| |..|.|:|....:  :|...||
Human   357 RRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAK 421

  Fly   373 --------AAANE------------------------RVPRSHSVGSI---RDMGPPNTEAERRI 402
                    :..|:                        ||.|.:.|.|.   ..:.....::...:
Human   422 WHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYL 486

  Fly   403 LDMVAAGGEAALMPSPTRTITPAQS-PVQTKRKLQPTVSTENAAGTTAKKKEKPANSSFVISKDG 466
            ||..:...|  :..:.:.|.||.:| .|...|..|.:.|...|.|    |..:.:.:|.|.|.|.
Human   487 LDFRSIDDE--ITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQG----KSSEVSLTSSVTSLDS 545

  Fly   467 APLTEAPPTIIEPQATLME-AETIANI 492
            :|:...|    .|.:..:| .|..||:
Human   546 SPVDLTP----RPGSHTIEFFEMCANL 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	119/295 (40%)
PRKAA1	NP_996790.3	STKc_AMPK_alpha	24..294	CDD:270981	118/261 (45%)
		UBA_AID_AAPK1	311..375	CDD:270586	6/63 (10%)
		AMPKA1_C	419..572	CDD:213384	33/160 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155242
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840