DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nuak1 and sik1

DIOPT Version :9

Sequence 1:	NP_001369005.1	Gene:	Nuak1 / 41256	FlyBaseID:	FBgn0262617	Length:	2803	Species:	Drosophila melanogaster
Sequence 2:	NP_001119855.1	Gene:	sik1 / 553465	ZFINID:	ZDB-GENE-030131-9446	Length:	811	Species:	Danio rerio

Alignment Length:	1095	Identity:	261/1095 - (23%)
Similarity:	410/1095 - (37%)	Gaps:	374/1095 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 FDIIKKLGQGTYGKVQLGINKETG-----------QEVAIKTIKKCKIEAEADLVRIRREVQIMS 123
            ::||:.||:|.:..|:|..:|.|.           .:||||.|.|.::.: |:|.:|.||||||.
Zfish    26 YEIIRTLGKGNFAVVKLARHKVTKTQAITTFYFIFMQVAIKIIDKTRLNS-ANLEKIYREVQIMK 89

  Fly   124 SVHHPNIIHIYEVFENREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHK 188
            .::||:||.:|:|.|.::.:.:|.|:|..||::|||:....::|.|||:.|.|:.|||.|||:|.
Zfish    90 LLNHPHIIKLYQVMETKDMLYIVTEYAKNGEMFDYLTSNGRMSENEARKKFWQILTAVDYCHRHH 154

  Fly   189 ICHRDLKLENILLDEKGNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWS 253
            |.|||||.||:|||...|.|:||||..|.::....|.|:||||.||:||:.||..|:||::|.||
Zfish   155 IVHRDLKTENLLLDANMNIKLADFGFGNFYNAGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWS 219

  Fly   254 LGVLLYTLVYGSMPFDGSNFKRLVKQISQGDYYEPRKPSR-ASTLIRDMLTVCPRKRASIEQICS 317
            |||:||.||.||:||||.:...|.:::::|.:..|...|: ...|||.||.|.|.||.:|.||..
Zfish   220 LGVVLYVLVCGSLPFDGDSLPALRQRVTEGRFRIPFFMSQDCENLIRKMLVVDPAKRITIAQIKQ 284

  Fly   318 HWWV-------NENDNVSCLDLAEDLANQTPVRLDVLLSL-TPATITADQLVVPSAEGAAAAKAA 374
            |.|:       ::..::|..|...:|.:.:...|.::.:| .....|.:.|...|....:|....
Zfish   285 HRWMLADPSAPHQTLSLSLTDYNSNLGDYSEPVLGIMQTLGIDRQRTVESLQNSSYNHFSAIYYL 349

  Fly   375 ANERVPRSHSVGSIRDMGPPNTEAERRILDMVAAGGEAALMPSPTRTITPAQSPVQTKRKLQPTV 439
            ..|||....|....|..|..|..                     :||.:.:.:|   :..::.:.
Zfish   350 LLERVKEHRSQQISRQCGAWNQR---------------------SRTASDSSTP---EVIMESSD 390

  Fly   440 STENAAGTTAKKKEKPANSSFVISKDGAPLTEAPPTIIEPQATLMEAETIANIPEEVPVPSYSQK 504
            |..|:|...|.|...|.:|.                        ||.|. ..:.:.|..|
Zfish   391 SFRNSAFPVATKVNAPIHSE------------------------MECEQ-GGLFQRVVCP----- 425

  Fly   505 DMQAVGDICDLLMGTATTPAPAPPAPTPVARQPTRGKLDAVVETPEEKDATKVIKKFVNKHKTAD 569
               ....:..||...:.:|                   ::::||        .|.:.|..|   |
Zfish   426 ---VEASLNGLLWNRSISP-------------------NSLLET--------TISEEVRPH---D 457

  Fly   570 LVNAINESASKAAAPVSAVAPPPF----VRKCSLQDESTLNKFNAERRKSRILETAEKFQPPPPV 630
            |         :....:..|.||..    .|:.:|.:.||          ||..:.:     ||.:
Zfish   458 L---------EEEEGILQVQPPHLPSTTSRRHTLAEVST----------SRFHQCS-----PPCI 498

  Fly   631 AAAPPEKPKKLSIPGVSVGSFKKEFEKKATNPPAA-----------EGPTPGELRAQEQVAAAAA 684
            ..:|.:        |.|..|..|  ....||||.:           .|..||.|
Zfish   499 VVSPSD--------GASSDSCLK--SSSNTNPPLSPVVGDFSSLLISGTGPGAL----------- 542

  Fly   685 AAQEAETLSTPPPSPVVAQSLEGSDSKNSVASISLDEARRSMENSIALLLQAQNESSKEVDQLCA 749
                     .|..:|:...|.....::.|:.:.|..|.||:.:.|:...|:|..:      ||
Zfish   543 ---------GPAGTPLALSSNLLLQNQGSMLAASFQEGRRASDTSLTQGLKAFRQ------QL-- 590

  Fly   750 QTETIGVSEPATQQERERKLKNARAIIG-NAIQPVIRRPTPFYGIGNGFGNGMGGAVGASGATVN 813
                             ||...|:.::| |.|:.:.|:..|
Zfish   591 -----------------RKNTRAKGLLGLNKIKGLARQVCP------------------------ 614

  Fly   814 NAPKRAQSGSSFMGYSGATSPGTAATSPPISGPQTAPPVLISPNALAVAKQTIQQRIFGGGLPSP 878
              |.....||.          |:.       ||...||            .::|.
Zfish   615 --PSSCSRGSR----------GSL-------GPTMCPP------------SSLQS---------- 638

  Fly   879 NNQPANRRPATWQPQASYSTASIFQPPQSQSSPFKMLQQQYQQRCQ-EDQKQSCPFTPPPSPQNA 942
            ::.|..||             |:.:....|.   :|||.|:|.:.| :...||.|.:||
Zfish   639 SSGPRERR-------------SMLEEVLHQQ---RMLQIQHQPQPQVQFLSQSHPSSPP------ 681

  Fly   943 ASHAYAAQANSNNYGGNSNSGASGGSSSN-------SRCNSSNIGNCNTMPYVNYNVNSRTRPFN 1000
                            ::|..|.....||       ..|..::|.                  |.
Zfish   682 ----------------SNNLFAPAALFSNPPTQAILPPCQKTSIA------------------FQ 712

  Fly  1001 HN-----QAQDTLNTNANTSASATCALPVAMWLKSSPGAEGPPTPPGAVKTSTASITLKSATLPR 1060
            ||     |:.|:.:::.:..|||...|...:.:..                             |
Zfish   713 HNLWQQQQSFDSSSSSLSPVASAAHLLEARLHISQ-----------------------------R 748

  Fly  1061 RKINAKAEVQLDIKPRIPEQGAP----PQP---AMRFSTEMQHPVADLRSAPPRE 1108
            ..::.::...|.|:|.:|.|| |    |.|   ::..|||.:..|.:|..|..::
Zfish   749 SHLHPQSPQHLQIQPNLPSQG-PFSLLPHPGSWSLSTSTEPEPNVQELICASQKQ 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	118/262 (45%)
sik1	NP_001119855.1	STKc_SIK	25..288	CDD:270973	118/262 (45%)
		S_TKc	26..288	CDD:214567	118/262 (45%)
		UBA_SIK1	309..358	CDD:270591	10/48 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590338
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840