Protein Alignment Nuak and Gm14151

DIOPT Version :10

• Sequence 1: NP_001369005.1
• Gene: Nuak / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Sequence 2: NP_001091446.1
• Gene: Gm14151 / 433486
• MGIID: 3651016
• Length: 640
• Species: Mus musculus
• Alignment Length: 584
• Identity: 155/584 - (26%)
• Similarity: 269/584 - (46%)
• Gaps: 110/584 - (18%)

  Fly    66 LRQRFDIIKKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNI 130
            |.:.::|:..|||||:|.|:|..:..|..:||||.:.:.:...     .::.|::||.|:.||:|
Mouse    20 LTEHYEILTTLGQGTFGDVKLANHLVTQTKVAIKILPQNRKNP-----LVQPEIEIMKSLDHPHI 79

  Fly   131 IHIYEVFENREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLK 195
            |.:..:.:....:.:|:|.|.||||.:.:.|...|.|.|..|:|:|:..|:.|||:..|.|||||
Mouse    80 IKLLHIIDTTRNIFIVLEHAVGGELMNRIEEFGYLAEVECHRLFKQLVYALQYCHEKGIVHRDLK 144

  Fly   196 LENILLDEKGNAKIADFGL-SNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLY 259
            .||||||.:||.|:.|||| :.:...|:|: ||||:..|.:||:.|...|.|...|.|||||:||
Mouse   145 PENILLDHRGNVKLTDFGLGTKIIMGQKLV-TFCGTLPYCAPELFEDRGYDGRATDVWSLGVVLY 208

  Fly   260 TLVYGSMPFDGSNFKRLVKQISQGDYYEPRKPSRASTL---IRDMLTVCPRKRASIEQICSHWWV 321
            .:..|.:||:|.:::.:.::|..|.|  ||..|.:..|   |..:|||.|.:|.::..|....|:
Mouse   209 FMATGCLPFNGYSYEAIKQKIIAGKY--PRSFSLSPELWEVIAKLLTVNPGERPTVHDIARFKWL 271

  Fly   322 NENDNVSCLDLAEDLANQTPVRLDVLLSL---TPATITA-------DQLVV-------------- 362
            ..::..|...|.|::.:.....:.||:.:   .|..|..       ||::.
Mouse   272 KPDNEASPASLGENIESHPDPSIMVLMGVMGYNPGEIRESLREKKFDQVMATYLMLKQQSAWENK 336

  Fly   363 ------------------PSAEGAAAAKAAANERVPRSHSVGSIRDMGPPNTEAERRILDMVAAG 409
                              |:.:...|.:.|::  || :||..|:     ||   |...|:.....
Mouse   337 TTKKPDPRLCDRMLRSTEPTIKNQTAVRRASS--VP-THSTFSL-----PN---ESESLEKGKRT 390

  Fly   410 GEAALMPSPTRT-----ITPAQS-------PVQTKRKL--QPTVSTENAAGTTAKKKEKPA---- 456
            ..:..|| |||.     .||..|       ....:|.:  :..:|..:...:|.:..|.|:
Mouse   391 TMSHSMP-PTRNCFNEETTPLHSICPQLVQKAHYRRSIWGETEISDTSEESSTGESLEHPSLKIH 454

  Fly   457 --NSSFVISKDGAPLTEAPPT--IIEPQATLMEAETI--ANIPEEV--PVPSYSQKDMQAVGDI- 512
              .:|..:||.|:..:::..:  .:....|.:|.:..  .||..|:  |:...|.:: ..:|.:
Mouse   455 TLQTSMGVSKAGSTYSKSKGSSQCVSSHHTSVEEDQCEGTNISREINPPLSPVSPQE-NLMGQLH 518

  Fly   513 -------CDLLMGTATTPAPAPPAPTPVARQPTRGKLDAVVETPEEKDATKVIKKFVN-KHKTA 568
                   .|::....|:|        |.:|:..:|:..|:.:......:...::..:: :|:||
Mouse   519 IVTTAGSMDIMNTQVTSP--------PFSRKEAKGEGPAIQQRESRPSSPNTLQGHLHGRHQTA 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nuak	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	97/256 (38%)
Gm14151	NP_001091446.1	STKc_AMPK-like	23..270	CDD:270905	97/254 (38%)
		UBA_MARK_Par1	290..328	CDD:270522	6/37 (16%)