DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nuak and MARK1

DIOPT Version :10

Sequence 1:NP_001369005.1 Gene:Nuak / 41256 FlyBaseID:FBgn0262617 Length:2803 Species:Drosophila melanogaster
Sequence 2:NP_001273053.1 Gene:MARK1 / 4139 HGNCID:6896 Length:796 Species:Homo sapiens


Alignment Length:740 Identity:211/740 - (28%)
Similarity:330/740 - (44%) Gaps:140/740 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 KKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFE 138
            |.:|:|.:.||:|..:..||:|||:|.|.|.::. ...|.::.|||:||..::||||:.::||.|
Human    64 KTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLN-PTSLQKLFREVRIMKILNHPNIVKLFEVIE 127

  Fly   139 NREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDE 203
            ..:.:.||||:|:|||::|||.....:.|:|||..|||:.:||.|||:..|.|||||.||:|||.
Human   128 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDG 192

  Fly   204 KGNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPF 268
            ..|.||||||.||.|.....|.||||||.||:||:.:|..|.|||||.|||||:|||||.||:||
Human   193 DMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 257

  Fly   269 DGSNFKRLVKQISQGDYYEPRKPSRAST----LIRDMLTVCPRKRASIEQICSHWWVN---ENDN 326
            ||.|.|.|.:::.:|.|   |.|...||    |::.:|.:.|.||.|:|||....|:|   |.:.
Human   258 DGQNLKELRERVLRGKY---RIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEE 319

  Fly   327 VSCLDLAEDLANQTPVRLDVLLSLTPATITADQLVVPSAEGAAAAKAAANERVPRSHSVGSIRDM 391
            :......:...|.|. |:|:::::   ....|::          ..|..|::.....:...:...
Human   320 LKPYTEPDPDFNDTK-RIDIMVTM---GFARDEI----------NDALINQKYDEVMATYILLGR 370

  Fly   392 GPPNTEAERRILDMVAAGGEA--------ALMPSPTRTITPAQSPVQTKRKLQPTVSTENAAGTT 448
            .||..|           |||:        ...||.....:..|||...  |:|.::|        
Human   371 KPPEFE-----------GGESLSSGNLCQRSRPSSDLNNSTLQSPAHL--KVQRSIS-------- 414

  Fly   449 AKKKEKPANSSFVISKDGAPLTEAPPTII---EPQATLMEAETIANIPEEVPVPSYSQKDMQAVG 510
            |.:|::.      .|....|  ..||.:.   .|||..:|:|......::|     ::|      
Human   415 ANQKQRR------FSDHAGP--SIPPAVSYTKRPQANSVESEQKEEWDKDV-----ARK------ 460

  Fly   511 DICDLLMGTATTPAPAPPAPTPVARQPTRGKLDAVVETPEE---------KDATKVIKKFVNKH- 565
                  :|:.|..:.:....:|:. .|.|.|...:   |..         :..|.|.::..::: 
Human   461 ------LGSTTVGSKSEMTASPLV-GPERKKSSTI---PSNNVYSGGSMARRNTYVCERTTDRYV 515

  Fly   566 -----KTADLVNAINESASKAAAPVSAVAPPPFVRKCSLQDESTLNKFNAERRKSRILETAEKFQ 625
                 |.:.|......|.|.|.:.|::..|....|.   |...:.:....:.....|.:.:|.::
Human   516 ALQNGKDSSLTEMSVSSISSAGSSVASAVPSARPRH---QKSMSTSGHPIKVTLPTIKDGSEAYR 577

  Fly   626 PPPPVAAAPPEKPKKLSIPGVSVGSFKKEFEKKATNPPAAEGPTPGELRAQEQVAAAAAAAQEAE 690
            |.......|...|...||...:..  :..|.:.:::.....|.   :||.:..||          
Human   578 PGSTTQRVPAASPSAHSISTATPD--RTRFPRGSSSRSTFHGE---QLRERRSVA---------- 627

  Fly   691 TLSTPPPSP-----VVAQSLEGSDSKNSVASISLDEARRSMENSIALLLQAQNESSKEVDQLCAQ 750
             .:.||.||     ..|.:..|: |...::.|:....||.         .::.|:|...|   ..
Human   628 -YNGPPASPSHETGAFAHARRGT-STGIISKITSKFVRRD---------PSEGEASGRTD---TS 678

  Fly   751 TETIGVSEPATQQERERKLKNARAI 775
            ..|.|  ||..:.:.|.|....|::
Human   679 RSTSG--EPKERDKEEGKDSKPRSL 701

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NuakNP_001369005.1 STKc_NUAK 68..321 CDD:270975 123/250 (49%)
MARK1NP_001273053.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40
STKc_MARK 59..311 CDD:270974 123/250 (49%)
UBA_MARK1 331..371 CDD:270588 7/53 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 377..495 31/156 (20%)
MARK1-3_C 697..794 CDD:213381 1/5 (20%)
Blue background indicates that the domain is not in the aligned region.

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