Protein Alignment Nuak and KP78b

DIOPT Version :10

• Sequence 1: NP_001369005.1
• Gene: Nuak / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Sequence 2: NP_650065.1
• Gene: KP78b / 41361
• FlyBaseID: FBgn0026063
• Length: 604
• Species: Drosophila melanogaster
• Alignment Length: 547
• Identity: 177/547 - (32%)
• Similarity: 268/547 - (48%)
• Gaps: 100/547 - (18%)

  Fly    70 FDIIKKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIY 134
            :.|||.||:|.:.||:|.|:..||:|||||.|.|..:...| ..::.|||.||..::||||:.:.
  Fly    63 YKIIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIA-RQKLYREVNIMKKLNHPNIVRLL 126

  Fly   135 EVFENREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENI 199
            :|.|:...:.||||:.:||||::||.:...:.|.:||.:|||:.:|:.|||...|.|||||.||:
  Fly   127 QVIESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAENL 191

  Fly   200 LLDEKGNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYG 264
            |||::...||||||.|..|:.:..|.||||||.||:||:..|..|.|||||.|||||:|||||.|
  Fly   192 LLDQQMKLKIADFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLVSG 256

  Fly   265 SMPFDGSNFKRLVKQISQGDYYEPRKPS-RASTLIRDMLTVCPRKRASIEQICSHWWVN---END 325
            |:||||:|.|.|..::.:|.|..|...| ...:|||..|.:.|.:|.|:..:.:..|:|   |..
  Fly   257 SLPFDGTNLKELRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWINMGYEQG 321

  Fly   326 N-----------------VSCL--------DLAEDLANQ-------TPVRLDVLLSLTPA----- 353
            |                 :|.|        |:.:.|.||       |.:.|||....:.|
  Fly   322 NGLRPFQEKPMDLHDVNRLSLLSNMGHKPRDVEQSLKNQKFDDIYCTYMLLDVAKPRSTACSEKS 386

  Fly   354 ------TITA----DQLVVP-SAEGAAAAKA--AANERVPRSHSVGSIRDMGPPNTEAERRILDM 405
                  |.||    .::.|| :|.....::.  |.::..|...:..|||.|.|       |:.:.
  Fly   387 GSSFRETPTAMPGSSRIPVPIAAPNVTISQVTFALDKSTPNRPAATSIRPMAP-------RLANA 444

  Fly   406 VAAGGEAALMPSPTRTITPAQSPVQTKRKLQPTVSTENAAGTTAKKKEKPANSSFVISKDGAPLT 470
            :.   ...|.|.|.:.|..:.|.....|:.:|:...::|    ..||..           |:|:
  Fly   445 LT---PLPLTPPPKKYICCSASKAANPRRSEPSSIPQSA----MPKKGV-----------GSPV- 490

  Fly   471 EAPPTIIEPQATLMEAETIANIPEEV--PV---PSYSQKDMQAVGDICDLLMGTAT--------- 521
            :...|::..|..|...:.:.:...::  |:   ||.:.:..:......::|..|:|
  Fly   491 DVKTTLLSAQRKLAVNQKLTSASHQIRSPITQSPSQASECTRTPPTHFEMLDSTSTPLKVLKLVA 555

  Fly   522 TPAPAPPAPTPVARQPTR----GKLDA 544
            :.:..||: |....:|||    .||.|
  Fly   556 SNSQTPPS-TENTNRPTRVGFFSKLSA 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nuak	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	118/251 (47%)
KP78b	NP_650065.1	Protein Kinases, catalytic domain	63..314	CDD:473864	118/251 (47%)
		UBA_MARK_Par1	335..373	CDD:270522	7/37 (19%)