DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nuak1 and snrkb

DIOPT Version :9

Sequence 1:	NP_001369005.1	Gene:	Nuak1 / 41256	FlyBaseID:	FBgn0262617	Length:	2803	Species:	Drosophila melanogaster
Sequence 2:	NP_957127.1	Gene:	snrkb / 393806	ZFINID:	ZDB-GENE-040426-1724	Length:	741	Species:	Danio rerio

Alignment Length:	792	Identity:	200/792 - (25%)
Similarity:	313/792 - (39%)	Gaps:	171/792 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 NNHRKKLRQRFDIIKKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLV--RIRREVQIM 122
            :.:..|:...:|:.:.||:|.:..|:|..:..|||.||:|.|.|.|::   ||.  .:.:||:.|
Zfish     6 SGYEGKIAGLYDLDRTLGKGHFAVVKLARHVFTGQLVAVKVIDKTKLD---DLATGHLLQEVRCM 67

  Fly   123 SSVHHPNIIHIYEVFENREKMVLVMEFAAGGELYDY-LSERKVLTEEEARRIFRQVATAVYYCHK 186
            ..|.|||::.:|||.:.:.|:.|::|...||::||| |.....:.|:.|:..|.|:..|:.|||:
Zfish    68 KLVQHPNVVRLYEVIDTQTKLYLILELGDGGDMYDYILRHEGGVAEDTAKVHFAQIVRAIAYCHR 132

  Fly   187 HKICHRDLKLENIL-LDEKGNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVD 250
            ..:.|||||.||:: ..::|..|:.|||.||.|....:|.|.|||..|::|||:.|..|..|.||
Zfish   133 LHVVHRDLKPENVVFFRQQGTVKLTDFGFSNHFKPGTMLMTSCGSLAYSAPEILLGEEYDAPAVD 197

  Fly   251 CWSLGVLLYTLVYGSMPFDGSNFKRLVKQISQGDYYEPRKPS-RASTLIRDMLTVCPRKRASIEQ 314
            .|||||:||.||.|..||..:|....:..|....|..|...| :...||..||...|.||||:.:
Zfish   198 IWSLGVILYMLVCGHPPFQETNDSETLIMIMDCRYTVPNHISAQCKDLISRMLQRDPAKRASLAE 262

  Fly   315 ICSHWWVNENDNVSCLDLAEDLANQTPVRLDVLLSLTPATITADQLVVPS---------AEGAAA 370
            |.||.|:...|             .:|.      ..|.|.:|:.:.::|.         ..|:.|
Zfish   263 IESHPWLQGVD-------------PSPA------GFTAAPLTSHRSLLPEEHEFILQAMTSGSIA 308

  Fly   371 AKAAANERVPR---SHSVGSIRDMGPPNTEAERRILDMVAAGGEAALMPSPTRTITPAQSPVQTK 432
            .:.|..|.:..   :|...:...:|      ||.:.|...   :::|.|....|..|...|:..
Zfish   309 GRDAIQEALEADRYNHITATYYLLG------ERLLRDKQE---QSSLTPEQRNTQRPISEPLDL- 363

  Fly   433 RKLQPTVSTENAAGTTAKKKEKPANSSFVISKDGAPLTEAPPTIIEPQATLMEAETIANIPE--E 495
              :.....|:...||                         |.:.:.|..:|........:.|  :
Zfish   364 --VSQVPRTDTLRGT-------------------------PLSALAPLGSLSTGYVRRGVSESGD 401

  Fly   496 VPVPSYSQKDMQAVGDICDLLMGTATTPAPAPPAPTPVARQPT---RGKLDAVVETPEEKDATKV 557
            :..|..::.| .:..|.|......:....|.||      .|||   .|.|..:.|..||:|..||
Zfish   402 LLAPKANRHD-NSFSDFCSTAPCLSLNMRPLPP------DQPTVKSLGALQQICEEEEEEDEVKV 459

  Fly   558 IKKFVNKHKTADLVNAINESASKAAAPVSAVAPPPFVRKCSLQDE--------STLNKFNAE--- 611
                              :.|.....|:.:........:.|||.|        |:....|.|
Zfish   460 ------------------KMAPGKLGPLPSTDLSLKPSRTSLQSEPQMRTGRHSSKGMGNCETLA 506

  Fly   612 RRKSRILETAEKFQPPPPVAAAPPEKPKKLSIPGVSVGSFKKEFEKKATNPPAAE------GPTP 670
            ..:..:.|.:|..:        ..:||..| :..:|.|:.:.:.|......|..|      .|..
Zfish   507 EEEEELEEGSESIE--------EHKKPLDL-VSSISSGTVEHQVEMPPKTEPQVEEFNHTKQPGK 562

  Fly   671 GELRAQEQVAAAAAAAQEAETLSTPP-----PSP--VVAQSLEG---------SDSKNSVASISL 719
            |..::.....:.:...||.|.:..|.     |:|  .|.|...|         .::.|::|...|
Zfish   563 GNDKSVFTHVSLSLEEQEGEEIQGPNVDGPLPAPRLDVVQCCWGQREPSKDILENNNNTLAKSRL 627

  Fly   720 DEA---------RRSMENSIALLLQAQN-ESSKEVDQLCAQTETIGVSEPATQQERERK-LKNAR 773
            .||         .||:..:..:.|.... |..|.|.:|         .:|...|.:.:| |:..|
Zfish   628 LEAGVISTPCGSPRSLPRNHCVDLGPDGVEMRKTVGEL---------EKPEEVQPKSQKVLQGTR 683

  Fly   774 AIIGNAIQPVIR 785
               |....|.||
Zfish   684 ---GTITDPTIR 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	102/257 (40%)
snrkb	NP_957127.1	STKc_SNRK	12..269	CDD:270976	102/259 (39%)
		S_TKc	16..269	CDD:214567	102/255 (40%)
		UBA_SNRK	290..335	CDD:270524	7/50 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590346
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930