Protein Alignment Nuak1 and LAD1

DIOPT Version :9

• Sequence 1: NP_001369005.1
• Gene: Nuak1 / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Sequence 2: NP_005549.2
• Gene: LAD1 / 3898
• HGNCID: 6472
• Length: 517
• Species: Homo sapiens
• Alignment Length: 635
• Identity: 128/635 - (20%)
• Similarity: 219/635 - (34%)
• Gaps: 188/635 - (29%)

  Fly  1674 PQLPQVAATEGTSSLRAGRSSQRRISRFLRPDFFDEPRDRETQSMLREIREKSIDRQDQEQTQPQ 1738
            |:|.|....:.::|.|.....:..:.:.|.|...||  |.:.||:||..:|:...||..|..|
Human    46 PRLSQNGDRQASASERLPSVEEAEVPKPLPPASKDE--DEDIQSILRTRQERRQRRQVVEAAQ-- 106

  Fly  1739 DLRRRKHSLPNVEQAEQPAETAPIRSSMRHSRNKSMELFTEAESNGQVRDTVKTSTSRQRSVSKA 1803
                                 |||:..:            |||..   |:::....:.|:.:...
Human   107 ---------------------APIQERL------------EAEEG---RNSLSPVQATQKPLVSK 135

  Fly  1804 RELE----TELDKHELADKILQELQLLSAVRSQHEQTQESEKA--EETSTIKKIKKLKPTESNEP 1862
            :|||    ..|.:.:.....|:|..|:.      .:.:|.:|.  |::..::|....|.|   .|
Human   136 KELEIPPRRRLSREQRGPWALEEESLVG------REPEERKKGVPEKSPVLEKSSMPKKT---AP 191

  Fly  1863 EATKIASTTTSSTTTLVRKVKKVVKKTDEAPKTTGSENADLASSAPKETKLKRPKSYPMKDLGLS 1927
            |.:.::..|:.|...|..:...:.:|...:.|...||...:........|...|        |::
Human   192 EKSLVSDKTSISEKVLASEKTSLSEKIAVSEKRNSSEKKSVLEKTSVSEKSLAP--------GMA 248

  Fly  1928 LKSSTDLPEPTTSLLPTKLPS-KLPSGNTNESAVEPAPRESRLMRPKSYPATKLATPKELRKVTR 1991
            |.|...|.....|:....|.| |.|:.:..                   ||.|.||..|.
Human   249 LGSGRRLVSEKASIFEKALASEKSPTADAK-------------------PAPKRATASEQ----- 289

  Fly  1992 SGVAIPTITEAIPTPSAMPTSTSSKSTSEEKSTSATPTGTMSAVTDAKDIVSSSSDSRPTTIKKI 2056
                        |.....|.|..|.:|::|:...|.|.                        |.:
Human   290 ------------PLAQEPPASGGSPATTKEQRGRALPG------------------------KNL 318

  Fly  2057 IKVSKKSKLMPPTPVTPTTPTTTATTTASTTPVESSKESSPVIKPKEKSPEKKPSKGLLYALGQK 2121
            ..::|:....|||..:...|.|.      ...:.|.:|.:.:..|.:::
Human   319 PSLAKQGASDPPTVASRLPPVTL------QVKIPSKEEEADMSSPTQRT---------------- 361

  Fly  2122 FEKLRDSAMSKEKKAGSTGAAASLACTQKQGSPEERSSPEKYKKNVSDT--EKSQQTGLSDD--K 2182
                               .::||    |:.||...|...|.||..|:|  .:|....|.|:  |
Human   362 -------------------YSSSL----KRSSPRTISFRMKPKKENSETTLTRSASMKLPDNTVK 403

  Fly  2183 RVDKRSRFDTMLR---SLRERSVPRSQ---PNGGVSPKRAASVEELHAGCPEGQGKQGGAVN-KM 2240
            ..:|..|:.|.:|   |::.|.:|.::   ...||:.||....:|| ||....:.......| ::
Human   404 LGEKLERYHTAIRRSESVKSRGLPCTELFVAPVGVASKRHLFEKEL-AGQSRAEPASSRKENLRL 467

  Fly  2241 FGGLLRRFD------RESSEQRRVRSSRSTSNIER-QVREEQDQLLDASL 2283
            .|.:..|.:      :||.:|....:.:::|..|| |..::.|..|||.:
Human   468 SGVVTSRLNLWISRTQESGDQDPQEAQKASSATERTQWGQKSDSSLDAEV 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975
LAD1	NP_005549.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..401		98/516 (19%)
		8 X SEK repeats	203..271		15/75 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..517		11/35 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12392
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100