Protein Alignment Nuak and HUNK

DIOPT Version :10

• Sequence 1: NP_001369005.1
• Gene: Nuak / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Sequence 2: NP_055401.1
• Gene: HUNK / 30811
• HGNCID: 13326
• Length: 714
• Species: Homo sapiens
• Alignment Length: 778
• Identity: 203/778 - (26%)
• Similarity: 322/778 - (41%)
• Gaps: 159/778 - (20%)

  Fly     2 VISKPDGTAPNGAAGGAEAAAPTGLDATGNSL-AHPSGIPQDQIDNIMSGIANTGNVKMNNHRKK 65
            ::.:|  .|| |..||||.||.......|:.| |..||:|::::.:.             .|.|:
Human     9 LLGEP--AAP-GGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDF-------------QHHKR 57

  Fly    66 LRQRFDIIKKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVR-IRREVQIMSSVHHPN 129
            :.......:|||:|::.||:.|::..||::||||.|.|.:.:.:..:.: :|||.||...:.|||
Human    58 VGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPN 122

  Fly   130 IIHIYEVFENREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDL 194
            |..:.::.|......||||...||.|...:.|:|.|.|.||||..||:.:||.:.|:..:.||||
Human   123 ITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDL 187

  Fly   195 KLENILLDEKGNAKIADFGLSNV-----FDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSL 254
            |:||:||||..|.|:.||||||.     :.|.  ..|.||||.||:||::....| ||::|.||:
Human   188 KIENLLLDEDNNIKLIDFGLSNCAGILGYSDP--FSTQCGSPAYAAPELLARKKY-GPKIDVWSI 249

  Fly   255 GVLLYTLVYGSMPFDGSNFK-RLVKQISQGDYYEPRKPSRAST----LIRDMLTVCPRKRASIEQ 314
            ||.:|.::.|::||....|. |.:.|........| .|::.||    .:|.:|...|.||.:|:|
Human   250 GVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNP-LPTQLSTGAISFLRSLLEPDPVKRPNIQQ 313

  Fly   315 ICSHWWVNEN--DNVSC------------------LDLAEDLANQTPVRLDVLLSLTPATITADQ 359
            ..::.|:|||  ..|.|                  |.:.|.|..:....::.:||.....|.|..
Human   314 ALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAIY 378

  Fly   360 LVVPSAEGAAAAKAAANERVPRSHSVGSIRDMGPPNTEAERRILDMVAAGGEAALMPS---PTR- 420
            .::                                |.:.||.:      .|::.:..|   .||
Human   379 FLL--------------------------------NKKLERYL------SGKSDIQDSLCYKTRL 405

  Fly   421 -TITPAQSPVQTKRKLQPTVST-----ENAAGTTAKKKEKPANSSFVISKDGAPLTEAPPTIIEP 479
             .|...::|   |...:.::.|     |..|....|.||:.....|:.......|.:..|:..:|
Human   406 YQIEKYRAP---KESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQP 467

  Fly   480 QATLME--AETIANIPE-EVPVPSYSQKDMQAVGDI--------CDLLMGTATTPAPAPPAP--- 530
            ..:||.  ..|.|.:.: :....|:..||.....:|        |.........|.|.|..|
Human   468 SGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRTPRIV 532

  Fly   531 -TPVARQPTRGK-----------LDAV--VETPEEKDATKVIK-----KFVNKHKTADLVNAINE 576
             .|...||..|.           ||.|  .|:.:..|..:|:.     :.:|...:....|: :|
Human   533 KKPEPHQPGPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNS-SE 596

  Fly   577 SASKAAAPVSAVAP--PPFVRKCSLQDESTLNKFNAERRKSRILETAEKFQPPPPVAAAPPEKP- 638
            .......|..:::|  .|.        ..||..|..|.:.|...|  |....||||.:..|.:|
Human   597 RTLSPGLPSGSMSPLHTPL--------HPTLVSFAHEDKNSPPKE--EGLCCPPPVPSNGPMQPL 651

  Fly   639 -------KKLSIPGVSVGSFKKEFEKKATNPPAAEGPTPGELRAQEQVAAAAAAAQEAETLST 694
                   .:...|.:.:|...:  ::..:..|:|:.|....|...:.:|....|...|:.:.|
Human   652 GSPNCVKSRGRFPMMGIGQMLR--KRHQSLQPSADRPLEASLPPLQPLAPVNLAFDMADGVKT 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nuak	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	100/263 (38%)
HUNK	NP_055401.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		8/19 (42%)
		STKc_HUNK	58..320	CDD:270972	100/265 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	437..471		7/33 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	518..552		8/33 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	590..615		4/25 (16%)