DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nuak and Smokl1

DIOPT Version :10

Sequence 1:NP_001369005.1 Gene:Nuak / 41256 FlyBaseID:FBgn0262617 Length:2803 Species:Drosophila melanogaster
Sequence 2:XP_218667.4 Gene:Smokl1 / 292948 RGDID:1560303 Length:494 Species:Rattus norvegicus


Alignment Length:399 Identity:126/399 - (31%)
Similarity:190/399 - (47%) Gaps:54/399 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 QRFDIIKKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIH 132
            :::.|:|.||||...:|:|..::.||..||:|.:    ::.|........||:||..::|.||:.
  Rat    27 RQYTILKPLGQGGTTEVRLSSHRLTGTPVAVKAL----VKHERHWASTMSEVEIMKILNHNNIVS 87

  Fly   133 IYEVFENREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLE 197
            :.:|.|..:.:.::||.|.|..|.:.:.:...|.|:|||.||.|:.:|:.|||...|.|||||.:
  Rat    88 LLQVMETEQNIYIIMEVAQGDSLLNRVQKAGRLKEDEARGIFVQLLSALGYCHGKGIIHRDLKPD 152

  Fly   198 NILLDEKGNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLV 262
            ||::||.||.||.||||...|...:.|...||:..:..||:..|.||.||:||.|:||||||.:|
  Rat   153 NIIVDEHGNVKIIDFGLGAKFLPGQKLKRLCGAFQFIPPELFLGLPYDGPKVDIWALGVLLYFMV 217

  Fly   263 YGSMPFDGSNFKRLVKQISQGDYYEPRKPSR-ASTLIRDMLTVCPRKRASIEQICSHWWVN---- 322
            .|..||.|:....|.|.:.||.|..|...|: ..::|..:|||..|:|.:.:.:.||.|:.    
  Rat   218 TGFAPFSGTTLSELSKNVLQGRYDIPYNLSKDLRSMISLLLTVNARQRPTAQDLSSHPWLQEWGK 282

  Fly   323 ---------------------ENDNVSCLDLAEDLANQ-------TPVRLDVLLSLTPATITADQ 359
                                 ||......|:.|.|.::       |.:.|.|............:
  Rat   283 TLTFHSNRDTSFPNRDIMVAMENIGFHVQDIKESLKHKKFDETMATYLLLRVQACQNGGNYVQTK 347

  Fly   360 LVVPSAEGAAAAKAAANERVPRSHSVGSIRDMGPPNTEAERRILDMVAAGGEAALMPSPTRTITP 424
            |:.|   |.|...:||:   |.:..:       ||...|....|.:|.|..|...:    |....
  Rat   348 LLNP---GVAPFPSAAD---PDTFPL-------PPRRRASEPSLKIVVASSEQQRL----RQSGG 395

  Fly   425 AQSPVQTKR 433
            ..:|||.|:
  Rat   396 TNAPVQPKK 404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NuakNP_001369005.1 STKc_NUAK 68..321 CDD:270975 98/253 (39%)
Smokl1XP_218667.4 STKc_AMPK-like 28..276 CDD:270905 98/251 (39%)
UBA_MARK_Par1 295..332 CDD:270522 6/36 (17%)

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